Abstract
Regenerative medicine has become an increasingly important field of research in contemporary bioscience. The importance of this research area is based on demographic changes in our aging societies and driven by the establishment of human embryonic stem cell lines. Disease-specific cell lines can be derived by various strategies, all aiming to enhance the understanding of disease at a cellular level and opening doors for drug discovery and development. The long-term goal of stem cells could lie in the potential to replace tissue and organs susceptible to age-related degeneration or traumatic injury.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Amano T et al (2009) Nuclear transfer embryonic stem cells provide an in vitro culture model for parkinson’s disease. Cloning Stem Cells 11:77–88
Aoi T et al (2008) Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 321:699–702
Briggs R, King TJ (1952) Transplantation of living nuclei from blastula cells into enucleate frogs’ eggs. Proc Natl Acad Sci 38(5):455–463
Bromhall JD (1975) Nuclear transplantation in the rabbit egg. Nature 258:719–722
Byrne JA et al (2007) Producing primate embryonic stem cells by somatic cell nuclear transfer. Nature 450:497–502
Chen Y et al (2003) Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes. Cell Res 13:251–263
Chung Y et al (2009) Reprogramming of human somatic cells using human and animal oocytes. Cloning Stem Cells 11(2):213–223
Cowan CA, Atienza J, Melton DA, Eggan K (2005) Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science 309:1369–1373
Dimos JT et al (2008) Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321:1218–1221
Ebert AD et al (2009) Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457:277–280
Gurdon JB (1962) The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. J Embryol Exp Morphol. 10:622–640
Gurdon JB, Uehlinger V (1966) ‘Fertile’ intestine nuclei. Nature 210:1240–1241
Hanna J et al (2007) Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318:1920–1923
Hanna J et al (2008) Direct reprogramming of terminally differentiated mature b lymphocytes to pluripotency. Cell 133(2):250–264
Huangfu D et al (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 26:1269–1275
Jingjuan J et al (2005) Experimental cloning of embryos through human-rabbit interspecies nuclear transfer. Zool Res 26:416–421
Kaji K et al (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458:771–775
Kim JB et al (2009) Oct4-induced pluripotency in adult neural stem cells. Cell 136(3):411–419
Lefebvre S et al (1995) Identification and characterization of a spinal muscular atrophy-determining gene. Cell 80:155–165
Li F et al (2008) Activation of human embryonic gene expression in cytoplasmic hybrid embryos constructed between bovine oocytes and human fibroblasts. Cloning Stem Cells 10:297–305
Lorincz MT, Detloff PJ, Albin RL, O’Shea KS (2004) Embryonic stem cells expressing expanded CAG repeats undergo aberrant neuronal differentiation and have persistent Oct-4 and REST/NRSF expression. Mol Cell Neurosci 26:135–143
Mitalipov SM et al (2007) Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling. Hum Reprod 22:2232–2242
Nakagawa M et al (2008) Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 26(1):101–106
Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S (2008) Generation of mouse induced pluripotent stem cells without viral vectors. Science 322:949–953
Park IH et al (2008) Disease-specific induced pluripotent stem cells. Cell 134(5):877–886
Piccini P et al (1999) Dopamine release from nigral transplants visualized in vivo in a Parkinson’s patient. Nat Neurosci 2:1137–1140
Shoubridge EA, Wai T (2007) Current topics in developmental biology. In: Justin CS (ed) The mitochondrion in the germline and early development. Academic, New York, pp 87–111
Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K (2008) Induced pluripotent stem cells generated without viral integration. Science 322:945–949
Stephenson EL et al (2009) Preimplantation genetic diagnosis as a source of human embryonic stem cells for disease research and drug discovery. BJOG 116:158–165
Stojkovic M et al (2005) Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes. Reprod Biomed Online 11:226–231
Tada M, Takahama Y, Abe K, Nakatsuji N, Tada T (2001) Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol 11(19):1553–1558
Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663–676
Takahashi K et al (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5):861–872
Taylor CJ et al (2005) Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching. Lancet 366:2019–2025
Thomson JA et al (1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145–1147
Vogel G (2006) Stem cells: ethical oocytes: available for a price. Science 313:155b
Wernig M et al (2007) In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448:318–324
Wernig M et al (2008) Neurons derived from reprogrammed fibroblasts functionally integrate into fetal brain and improve symptoms of rats with Parkinson’s disease. PNAS 105:5856–5861
Wilmut I et al (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385:810–813
Woltjen K et al (2009) piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458:766–770
Yu J et al (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917–1920
Yu J et al (2009) Assessment of the developmental competence of human somatic cell nuclear transfer embryos by oocyte morphology classification. Hum Reprod 1:1–9
Zhou H et al (2009) Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4:381–384
Zwaka TM, Thomson JA (2003) Homologous recombination in human embryonic stem cells. Nat Biotechnol 21:319–321
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Gögel, S., Minger, S.L. (2011). The Generation of Disease-Specific Cell Lines and Their Use for Developing Drug Therapies. In: Ainscough, J., Yamanaka, S., Tada, T. (eds) Nuclear Reprogramming and Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-225-0_17
Download citation
DOI: https://doi.org/10.1007/978-1-61779-225-0_17
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61779-224-3
Online ISBN: 978-1-61779-225-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)