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The Handbook of Neuroprotection pp 1–24Cite as

Introduction

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Abstract

A neuroprotectant is generally defined as an agent that prevents neuronal death by inhibiting one or more of the pathophysiological steps in the processes that follow injury to the nervous system or ischemia due to occlusion of an artery or hypoxia due to any cause. This definition has now been extended to include protection against neurodegeneration and neurotoxins. The extended definition includes interventions that slow or halt the progression of neuronal degeneration. This book will describe the natural mechanisms of neuroprotection, agents used as neuroprotectives, and therapeutic neuroprotection in all neurological disorders where there is danger of progression of neurological damage regardless of the pathological process or clinical features. Prophylactic neuroprotection during anesthesia and surgery is also discussed. Neuroprotection may also be used for prevention of progression of a disease if it can be identified at a presymptomatic stage. The term neuroprotective, although an adjective, will be used as a noun in preference to neuroprotectant.

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Authors and Affiliations

  1. Jain PharmaBiotech, Blaesiring 7, Basel, 4057, Switzerland

    Kewal K. Jain

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  1. Kewal K. Jain
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Correspondence to Kewal K. Jain .

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Jain, K.K. (2011). Introduction. In: The Handbook of Neuroprotection. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-049-2_1

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