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Stem Cells & Regenerative Medicine pp 45–57Cite as

Bmi1 in Self-Renewal and Homeostasis of Pancreas

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

In mammalian organisms homeostasis is the central mechanism maintaining and preserving organ and tissue integrity. Stem cells are the main players in homeostatic balance: through self-renewal and multilineage differentiation, stem cells provide an endless supply of fresh, new cells throughout the lifetime of an organism. Bmi1 is one of the genes with a role in stem cell self-renewal and homeostasis in several organs and tissues. Its role in pancreas has been recently highlighted by two studies. In exocrine pancreas Bmi1 labels a population of differentiated acinar cells able to self-renew for more than 1 year, while in the endocrine pancreas absence of Bmi1 is associated with impaired beta cell regeneration upon damage. These experiments highlight Bmi1’s central position in maintaining organ homeostasis. The recent discovery that Bmi1 plays a crucial role in mitochondrial function makes it possible to hypothesize that this gene is one of the master regulators of tissue maintenance controlling stem cell self-renewal and mitochondrial metabolism.

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Author information

Authors and Affiliations

  1. Istituto di Genetica Medica, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168, Roma, Italy

    Eugenio Sangiorgi

Authors
  1. Eugenio Sangiorgi
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  2. Mario Capecchi
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Correspondence to Eugenio Sangiorgi .

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Editors and Affiliations

  1. Gene Expression Systems, Inc., Waltham, Massachusetts, USA

    Krishnarao Appasani

  2. Student Science, Wyllys Ave 45, Middletown, 06459, Connecticut, USA

    Raghu K. Appasani

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Sangiorgi, E., Capecchi, M. (2011). Bmi1 in Self-Renewal and Homeostasis of Pancreas. In: Appasani, K., Appasani, R. (eds) Stem Cells & Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-860-7_3

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