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Visceral Sensitivity

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Pediatric Neurogastroenterology

Part of the book series: Clinical Gastroenterology ((CG))

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Abstract

The GI tract has a rich afferent innervation that can sample mechanical, chemical, and thermal stimuli. Sensory information reaching cortex can give rise to conscious sensations, painful or not. Abnormal heightened visceral sensitivity has been associated with FGID. This chapter describes the sensory innervation of the GI tract. The physiology of visceral sensitivity and the mechanisms leading to visceral hypersensitivity are described and discussed.

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References

  1. Drossman D, Camilleri M, Mayer E, Whitehead W. AGA technical review on irritable bowel syndrome. Gastroenterology. 2002;123:2108–31.

    Article  PubMed  Google Scholar 

  2. Aziz Q, Thompson DG. Brain-gut axis in health and disease. Gastroenterology. 1998;114:559–78.

    Article  PubMed  CAS  Google Scholar 

  3. Bielefeldt K, Christianson JA, Davis BM. Basic and clinical aspects of visceral sensation: transmission in the CNS. Neurogastroenterol Motil. 2005;17:488–99.

    Article  PubMed  CAS  Google Scholar 

  4. Berthoud HR, Blackshaw LA, Brookes SJ, Grundy D. Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract. Neurogastroenterol Motil. 2004;16 Suppl 1:28–33.

    Article  PubMed  Google Scholar 

  5. Brierley SM. Molecular basis of mechanosensitivity. Auton Neurosci. 2010;153:58–68.

    Article  PubMed  CAS  Google Scholar 

  6. Blackshaw LA, Brookes SJ, Grundy D, Schemann M. Sensory transmission in the gastrointestinal tract. Neurogastroenterol Motil. 2007;19:1–19.

    Article  PubMed  CAS  Google Scholar 

  7. Raybould HE. Gut chemosensing: Interactions between gut endocrine cells and visceral afferents. Auton Neurosci. 2010;153:41–6.

    Article  PubMed  CAS  Google Scholar 

  8. Braun T, Voland P, Kunz L, Prinz C, Gratzl M. Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology. 2007;132:1890–901.

    Article  PubMed  CAS  Google Scholar 

  9. Bertrand PP, Kunze WA, Bornstein JC, Furness JB, Smith ML. Analysis of the responses of myenteric neurons in the small intestine to chemical stimulation of the mucosa. Am J Physiol. 1997;273:G422–35.

    PubMed  CAS  Google Scholar 

  10. Beyak MJ. Visceral afferents—determinants and modulation of excitability. Auton Neurosci. 2010;153:69–78.

    Article  PubMed  CAS  Google Scholar 

  11. Kirkup AJ, Brunsden AM, Grundy D. Receptors and transmission in the brain-gut axis: potential for novel therapies. I. Receptors on visceral afferents. Am J Physiol Gastrointest Liver Physiol. 2001;280:G787–94.

    PubMed  CAS  Google Scholar 

  12. Christianson JA, Bielefeldt K, Altier C, Cenac N, Davis BM, Gebhart GF, High KW, Kollarik M, Randich A, Undem B, Vergnolle N. Development, plasticity and modulation of visceral afferents. Brain Res Rev. 2009;60:171–86.

    Article  PubMed  CAS  Google Scholar 

  13. Brierley SM, Hughes PA, Page AJ, Kwan KY, Martin CM, O’Donnell TA, Cooper NJ, Harrington AM, Adam B, Liebregts T, Holtmann G, Corey DP, Rychkov GY, Blackshaw LA. The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology. 2009;137:2084–2095 e3.

    Article  PubMed  CAS  Google Scholar 

  14. Jones 3rd RC, Xu L, Gebhart GF. The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3. J Neurosci. 2005;25:10981–9.

    Article  PubMed  CAS  Google Scholar 

  15. Jones 3rd RC, Otsuka E, Wagstrom E, Jensen CS, Price MP, Gebhart GF. Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse. Gastroenterology. 2007;133:184–94.

    Article  PubMed  Google Scholar 

  16. Masamichi S, Bin F, Gebhart GF. Peripheral and central P2X3 receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse. Gastroenterology. 2009;13(6):2096–104.

    Google Scholar 

  17. Cenac N, Altier C, Chapman K, Liedtke W, Zamponi G, Vergnolle N. Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. Gastroenterology. 2008;135:937–46. 946 e1–2.

    Article  PubMed  CAS  Google Scholar 

  18. Brierley SM, Page AJ, Hughes PA, Adam B, Liebregts T, Cooper NJ, Holtmann G, Liedtke W, Blackshaw LA. Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology. 2008;134:2059–69.

    Article  PubMed  CAS  Google Scholar 

  19. Cenac N, Andrews CN, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G, Beck P, Bunnett NW, Sharkey KA, Ferraz JG, Shaffer E, Vergnolle N. Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest. 2007;117:636–47.

    Article  PubMed  CAS  Google Scholar 

  20. Auge C, Balz-Hara D, Steinhoff M, Vergnolle N, Cenac N. Protease-activated receptor-4 (PAR(4)): a role as inhibitor of visceral pain and hypersensitivity. Neurogastroenterol Motil. 2009;21(11):1189–e107.

    Article  PubMed  CAS  Google Scholar 

  21. Altschuler SM, Bao XM, Bieger D, Hopkins DA, Miselis RR. Viscerotopic representation of the upper alimentary tract in the rat: sensory ganglia and nuclei of the solitary and spinal trigeminal tracts. J Comp Neurol. 1989;283:248–68.

    Article  PubMed  CAS  Google Scholar 

  22. Van Oudenhove L, Demyttenaere K, Tack J, Aziz Q. Central nervous system involvement in functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol. 2004;18:663–80.

    Article  PubMed  Google Scholar 

  23. Tillisch A, Mayer E, Labus J. Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology. 2011;140:91–100.

    Article  PubMed  Google Scholar 

  24. Faure C, Wieckowska A. Somatic referral of visceral sensations and rectal sensory threshold for pain in children with functional gastrointestinal disorders. J Pediatr. 2007;150:66–71.

    Article  PubMed  Google Scholar 

  25. Van Ginkel R, Voskuijl WP, Benninga MA, Taminiau JA, Boeckxstaens GE. Alterations in rectal sensitivity and motility in childhood irritable bowel syndrome. Gastroenterology. 2001;120:31–8.

    Article  PubMed  Google Scholar 

  26. Iovino P, Tremolaterra F, Boccia G, Miele E, Ruju FM, Staiano A. Irritable bowel syndrome in childhood: visceral hypersensitivity and psychosocial aspects. Neurogastroenterol Motil. 2009;21:940–e74.

    Article  PubMed  CAS  Google Scholar 

  27. Di Lorenzo C, Youssef NN, Sigurdsson L, Scharff L, Griffiths J, Wald A. Visceral hyperalgesia in children with functional abdominal pain. J Pediatr. 2001;139:838–43.

    Article  PubMed  Google Scholar 

  28. Halac U, Noble A, Faure C. Rectal sensory threshold for pain is a diagnostic marker of irritable bowel syndrome and functional abdominal pain in children. J Pediatr. 2010;156:60–65 e1.

    Article  PubMed  Google Scholar 

  29. Camilleri M, McKinzie S, Busciglio I, Low PA, Sweetser S, Burton D, Baxter K, Ryks M, Zinsmeister AR. Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2008;6:772–81.

    Article  PubMed  Google Scholar 

  30. Mertz H, Naliboff B, Munakata J, Niazi N, Mayer E. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology. 1995;109:40–52.

    Article  PubMed  CAS  Google Scholar 

  31. Whitehead WE, Holtkotter B, Enck P, Hoelzl R, Holmes KD, Anthony J, Shabsin HS, Schuster MM. Tolerance for rectosigmoid distention in irritable bowel syndrome. Gastroenterology. 1990;98:1187–92.

    PubMed  CAS  Google Scholar 

  32. Bouin M, Plourde V, Boivin M, Riberdy M, Lupien F, Laganiere M, Verrier P, Poitras P. Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds. Gastroenterology. 2002;122:1771–7.

    Article  PubMed  Google Scholar 

  33. Schmulson M, Chang L, Naliboff B, Lee OY, Mayer EA. Correlation of symptom criteria with perception thresholds during rectosigmoid distension in irritable bowel syndrome patients. Am J Gastroenterol. 2000;95:152–6.

    Article  PubMed  CAS  Google Scholar 

  34. Bradette M, Delvaux M, Staumont G, Fioramonti J, Bueno L, Frexinos J. Evaluation of colonic sensory thresholds in IBS patients using a barostat. Definition of optimal conditions and comparison with healthy subjects. Dig Dis Sci. 1994;39:449–57.

    Article  PubMed  CAS  Google Scholar 

  35. Bouin M, Meunier P, Riberdy-Poitras M, Poitras P. Pain hypersensitivity in patients with functional gastrointestinal disorders: a gastrointestinal-specific defect or a general systemic condition? Dig Dis Sci. 2001;46:2542–8.

    Article  PubMed  CAS  Google Scholar 

  36. Naliboff BD, Munakata J, Fullerton S, Gracely RH, Kodner A, Harraf F, Mayer EA. Evidence for two distinct perceptual alterations in irritable bowel syndrome. Gut. 1997;41:505–12.

    Article  PubMed  CAS  Google Scholar 

  37. Spetalen S, Jacobsen MB, Vatn MH, Blomhoff S, Sandvik L. Visceral sensitivity in irritable bowel syndrome and healthy volunteers: reproducibility of the rectal barostat. Dig Dis Sci. 2004;49:1259–64.

    Article  PubMed  Google Scholar 

  38. Coffin B, Azpiroz F, Guarner F, Malagelada JR. Selective gastric hypersensitivity and reflex hyporeactivity in functional dyspepsia. Gastroenterology. 1994;107:1345–51.

    PubMed  CAS  Google Scholar 

  39. Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J. Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology. 2001;121:526–35.

    Article  PubMed  CAS  Google Scholar 

  40. Tack J, Caenepeel P, Corsetti M, Janssens J. Role of tension receptors in dyspeptic patients with hypersensitivity to gastric distention. Gastroenterology. 2004;127:1058–66.

    Article  PubMed  Google Scholar 

  41. Mertz H, Fullerton S, Naliboff B, Mayer EA. Symptoms and visceral perception in severe functional and organic dyspepsia. Gut. 1998;42:814–22.

    Article  PubMed  CAS  Google Scholar 

  42. Bouin M, Lupien F, Riberdy M, Boivin M, Plourde V, Poitras P. Intolerance to visceral distension in functional dyspepsia or irritable bowel syndrome: an organ specific defect or a pan intestinal dysregulation? Neurogastroenterol Motil. 2004;16:311–4.

    Article  PubMed  CAS  Google Scholar 

  43. Mayer EA, Collins SM. Evolving pathophysiologic models of functional gastrointestinal disorders. Gastroenterology. 2002;122:2032–48.

    Article  PubMed  Google Scholar 

  44. Mayer EA, Bradesi S, Chang L, Spiegel BM, Bueller JA, Naliboff BD. Functional GI disorders: from animal models to drug development. Gut. 2008;57:384–404.

    Article  PubMed  CAS  Google Scholar 

  45. Peiris M, Bulmer DC, Baker MD, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q, Knowles CH. Human visceral afferent recordings: preliminary report. Gut. 2011;60:204–8.

    Article  PubMed  Google Scholar 

  46. Jiang W, Adam IJ, Kitsanta P, Tiernan J, Hill C, Shorthouse A, Grundy D. ‘First-in-man’: characterising the mechanosensitivity of human colonic afferents. Gut. 2011;60:281–2.

    Article  PubMed  Google Scholar 

  47. Saps M, Pensabene L, Di Martino L, Staiano A, Wechsler J, Zheng X, Di Lorenzo C. Post-infectious functional gastrointestinal disorders in children. J Pediatr. 2008;152:812–6. 816 e1.

    Article  PubMed  Google Scholar 

  48. Spiller R, Garsed K. Postinfectious irritable bowel syndrome. Gastroenterology. 2009;136:1979–88.

    Article  PubMed  Google Scholar 

  49. Tornblom H, Lindberg G, Nyberg B, Veress B. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology. 2002;123:1972–9.

    Article  PubMed  Google Scholar 

  50. Chadwick VS, Chen W, Shu D, Paulus B, Bethwaite P, Tie A, Wilson I. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology. 2002;122:1778–83.

    Article  PubMed  Google Scholar 

  51. Piche T, Saint-Paul MC, Dainese R, Marine-Barjoan E, Iannelli A, Montoya ML, Peyron JF, Czerucka D, Cherikh F, Filippi J, Tran A, Hebuterne X. Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome. Gut. 2008;57:468–73.

    Article  PubMed  CAS  Google Scholar 

  52. Liebregts T, Adam B, Bredack C, Roth A, Heinzel S, Lester S, Downie-Doyle S, Smith E, Drew P, Talley NJ, Holtmann G. Immune activation in patients with irritable bowel syndrome. Gastroenterology. 2007;132:913–20.

    Article  PubMed  CAS  Google Scholar 

  53. Aerssens J, Camilleri M, Talloen W, Thielemans L, Gohlmann HW, Van Den Wyngaert I, Thielemans T, De Hoogt R, Andrews CN, Bharucha AE, Carlson PJ, Busciglio I, Burton DD, Smyrk T, Urrutia R, Coulie B. Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2008;6:194–205.

    Article  PubMed  CAS  Google Scholar 

  54. Gue M, Del Rio-Lacheze C, Eutamene H, Theodorou V, Fioramonti J, Bueno L. Stress-induced visceral hypersensitivity to rectal distension in rats: role of CRF and mast cells. Neurogastroenterol Motil. 1997;9:271–9.

    Article  PubMed  CAS  Google Scholar 

  55. Eutamene H, Theodorou V, Fioramonti J, Bueno L. Acute stress modulates the histamine content of mast cells in the gastrointestinal tract through interleukin-1 and corticotropin-releasing factor release in rats. J Physiol. 2003;553:959–66.

    Article  PubMed  CAS  Google Scholar 

  56. Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, Pasquinelli G, Morselli-Labate AM, Grady EF, Bunnett NW, Collins SM, Corinaldesi R. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology. 2004;126:693–702.

    Article  PubMed  Google Scholar 

  57. Klooker TK, Braak B, Koopman KE, Welting O, Wouters MM, van der Heide S, Schemann M, Bischoff SC, van den Wijngaard RM, Boeckxstaens GE. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010;59:1213–21.

    Article  PubMed  CAS  Google Scholar 

  58. Santos J, Saperas E, Nogueiras C, Mourelle M, Antolin M, Cadahia A, Malagelada JR. Release of mast cell mediators into the jejunum by cold pain stress in humans. Gastroenterology. 1998;114:640–8.

    Article  PubMed  CAS  Google Scholar 

  59. Barbara G, Wang B, Stanghellini V, de Giorgio R, Cremon C, Di Nardo G, Trevisani M, Campi B, Geppetti P, Tonini M, Bunnett NW, Grundy D, Corinaldesi R. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology. 2007;132:26–37.

    Article  PubMed  CAS  Google Scholar 

  60. van den Wijngaard RM, Klooker TK, Welting O, Stanisor OI, Wouters MM, van der Coelen D, Bulmer DC, Peeters PJ, Aerssens J, de Hoogt R, Lee K, de Jonge WJ, Boeckxstaens GE. Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats. Neurogastroenterol Motil. 2009;21(10):1107–e94.

    Article  PubMed  Google Scholar 

  61. Barreau F, Salvador-Cartier C, Houdeau E, Bueno L, Fioramonti J. Long-term alterations of colonic nerve-mast cell interactions induced by neonatal maternal deprivation in rats. Gut. 2008;57:582–90.

    Article  PubMed  CAS  Google Scholar 

  62. Gershon MD. Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther. 1999;13 Suppl 2:15–30.

    PubMed  Google Scholar 

  63. Gershon MD. Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. J Clin Gastroenterol. 2005;39:S184–93.

    Article  PubMed  Google Scholar 

  64. Tack J, Sarnelli G. Serotonergic modulation of visceral sensation: upper gastrointestinal tract. Gut. 2002;51:77i–80.

    Article  Google Scholar 

  65. Camilleri M. Serotonergic modulation of visceral sensation: lower gut. Gut. 2002;51:81i–6.

    Article  Google Scholar 

  66. Mawe GM, Coates MD, Moses PL. Review article: intestinal serotonin signalling in irritable bowel syndrome. Aliment Pharmacol Ther. 2006;23:1067–76.

    Article  PubMed  CAS  Google Scholar 

  67. Chen JX, Pan H, Rothman TP, Wade PR, Gershon MD. Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception. Am J Physiol. 1998;275:G433–48.

    PubMed  CAS  Google Scholar 

  68. Chen JJ, Li Z, Pan H, Murphy DL, Tamir H, Koepsell H, Gershon MD. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci. 2001;21:6348–61.

    PubMed  CAS  Google Scholar 

  69. Wade PR, Chen J, Jaffe B, Kassem IS, Blakely RD, Gershon MD. Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J Neurosci. 1996;16:2352–64.

    PubMed  CAS  Google Scholar 

  70. Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M, Neal KR. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 2000;47:804–11.

    Article  PubMed  CAS  Google Scholar 

  71. Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Moses PL. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology. 2004;126:1657–64.

    Article  PubMed  CAS  Google Scholar 

  72. Camilleri M, Andrews CN, Bharucha AE, Carlson PJ, Ferber I, Stephens D, Smyrk TC, Urrutia R, Aerssens J, Thielemans L, Gohlmann H, van den Wyngaert I, Coulie B. Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. Gastroenterology. 2007;132:17–25.

    Article  PubMed  CAS  Google Scholar 

  73. Faure C, Patey N, Gauthier C, Brooks EM, Mawe GM. Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients. Gastroenterology. 2010;139:249–58.

    Article  PubMed  CAS  Google Scholar 

  74. Park JH, Rhee PL, Kim G, Lee JH, Kim YH, Kim JJ, Rhee JC, Song SY. Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea-predominant irritable bowel syndrome. Neurogastroenterol Motil. 2006;18:539–46.

    Article  PubMed  CAS  Google Scholar 

  75. Winston J, Shenoy M, Medley D, Naniwadekar A, Pasricha PJ. The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats. Gastroenterology. 2007;132:615–27.

    Article  PubMed  CAS  Google Scholar 

  76. Akbar A, Yiangou Y, Facer P, Walters JR, Anand P, Ghosh S. Increased capsaicin receptor TRPV1 expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut. 2008;57:923–9.

    Article  PubMed  CAS  Google Scholar 

  77. Sugiuar T, Bielefeldt K, Gebhart GF. TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation. J Neurosci. 2004;24:9521–30.

    Article  PubMed  Google Scholar 

  78. Gatti R, Andre E, Amadesi S, Dinh TQ, Fischer A, Bunnett NW, Harrison S, Geppetti P, Trevisani M. Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs. J Appl Physiol. 2006;101:506–11.

    Article  PubMed  CAS  Google Scholar 

  79. Sipe WE, Brierley SM, Martin CM, Phillis BD, Cruz FB, Grady EF, Liedtke W, Cohen DM, Vanner S, Blackshaw LA, Bunnett NW. Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1288–98.

    Article  PubMed  CAS  Google Scholar 

  80. Kawabata A, Matsunami M, Sekiguchi F. Gastrointestinal roles for proteinase-activated receptors in health and disease. Br J Pharmacol. 2008;153 Suppl 1:S230–40.

    PubMed  CAS  Google Scholar 

  81. Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, Bunnett NW. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med. 2000;6:151–8.

    Article  PubMed  CAS  Google Scholar 

  82. Hyun E, Andrade-Gordon P, Steinhoff M, Vergnolle N. Protease-activated receptor-2 activation: a major actor in intestinal inflammation. Gut. 2008;57:1222–9.

    Article  PubMed  CAS  Google Scholar 

  83. Coelho AM, Vergnolle N, Guiard B, Fioramonti J, Bueno L. Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats. Gastroenterology. 2002;122:1035–47.

    Article  PubMed  CAS  Google Scholar 

  84. Kayssi A, Amadesi S, Bautista F, Bunnett NW, Vanner S. Mechanisms of protease-activated receptor 2-evoked hyperexcitability of nociceptive neurons innervating the mouse colon. J Physiol. 2007;580:977–91.

    Article  PubMed  CAS  Google Scholar 

  85. Annahazi A, Gecse K, Dabek M, Ait-Belgnaoui A, Rosztoczy A, Roka R, Molnar T, Theodorou V, Wittmann T, Bueno L, Eutamene H. Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice. Pain. 2009;144:209–17.

    Article  PubMed  CAS  Google Scholar 

  86. Akbar A, Walters JR, Ghosh S. Review article: visceral hypersensitivity in irritable bowel syndrome: molecular mechanisms and therapeutic agents. Aliment Pharmacol Ther. 2009;30:423–35.

    Article  PubMed  CAS  Google Scholar 

  87. Mcmillan NA, Creelman CD. Detection theory: a user’s guide. New York: Laurence Elbaum Associates Inc.; 2005.

    Google Scholar 

  88. Clark WC. Pain sensitivity and the report of pain: an introduction to sensory decision theory. Anesthesiology. 1974;40:272–87.

    Article  PubMed  CAS  Google Scholar 

  89. Harvey LOJ. Detection sensitivity and response bias. In: http://psych.colorado.edu/~lharvey/p4165/p4165_2003_spring/2003_Spring_pdf/P4165_SDT.pdf ed, 2003.

  90. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152:S2–15.

    Article  PubMed  Google Scholar 

  91. Zhang J, Shi XQ, Echeverry S, Mogil JS, De Koninck Y, Rivest S. Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci. 2007;27:12396–406.

    Article  PubMed  CAS  Google Scholar 

  92. Bradesi S, Svensson CI, Steinauer J, Pothoulakis C, Yaksh TL, Mayer EA. Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology. 2009;136(1339–48):e1–2.

    Google Scholar 

  93. Coffin B, Bouhassira D, Sabate JM, Barbe L, Jian R. Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome. Gut. 2004;53:1465–70.

    Article  PubMed  CAS  Google Scholar 

  94. Piche M, Arsenault M, Poitras P, Rainville P, Bouin M. Widespread hypersensitivity is related to altered pain inhibition processes in irritable bowel syndrome. Pain. 2010;148:49–58.

    Article  PubMed  Google Scholar 

  95. Zhou Q, Fillingim RB, Riley 3rd JL, Malarkey WB, Verne GN. Central and peripheral hypersensitivity in the irritable bowel syndrome. Pain. 2010;148:454–61.

    Article  PubMed  CAS  Google Scholar 

  96. Zohsel K, Hohmeister J, Flor H, Hermann C. Somatic pain sensitivity in children with recurrent abdominal pain. Am J Gastroenterol. 2008;103:1517–23.

    Article  PubMed  Google Scholar 

  97. Dorn SD, Palsson OS, Thiwan SI, Kanazawa M, Clark WC, van Tilburg MA, Drossman DA, Scarlett Y, Levy RL, Ringel Y, Crowell MD, Olden KW, Whitehead WE. Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity. Gut. 2007;56:1202–9.

    Article  PubMed  Google Scholar 

  98. Corsetti M, Ogliari C, Marino B, Basilisco G. Perceptual sensitivity and response bias during rectal distension in patients with irritable bowel syndrome. Neurogastroenterol Motil. 2005;17:541–7.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Christophe Faure M.D. .

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Faure, C. (2013). Visceral Sensitivity. In: Faure, C., Di Lorenzo, C., Thapar, N. (eds) Pediatric Neurogastroenterology. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-709-9_4

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