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Dietary Flavonoids as Modulators of NO Bioavailability in Acute and Chronic Cardiovascular Diseases

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Nitrite and Nitrate in Human Health and Disease

Part of the book series: Nutrition and Health ((NH))

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Key points

  • Coronary heart disease and acute myocardial infarction remain the leading causes of death worldwide.

  • Diet compositions have gained much attention in prevention from chronic cardiovascular diseases.

  • Flavonoids – found in high concentration in green tea, red wine and cocoa – are naturally occurring polyphenols.

  • Improvement of diseases leading to arteriosclerosis (diabetes, hypertension) has been demonstrated in several randomized clinical trials under treatment with flavonoids.

  • Cytoprotection by flavonoids has been largely related to modulation of nitric oxide bioavailability.

  • Experimental evidence also suggests that flavonoids can alleviate myocardial damage in acute events, e.g., an acute myocardial infarction.

  • Randomized clinical trials investigating the role of dietary interventions with flavonoids in acute myocardial infarctions have yet to be conducted.

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Authors and Affiliations

  1. Department of Medicine, The University of Duesseldorf, Duesseldorf, Germany

    Tienush Rassaf

  2. Klinik für Kardiologie, Pneumologie, Angiologie, Moorenstrasse 5, 40225, Düsseldorf, Germany

    Tienush Rassaf

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  1. Matthias Totzeck
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  2. Malte Kelm
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  3. Tienush Rassaf
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Correspondence to Tienush Rassaf .

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  1. Health Science Center, Houston, Inst. Molecular Medicine, University of Texas, Pressler Street 1825, Houston, 77030, Texas, USA

    Nathan S. Bryan

  2. Brigham & Women's Hospital, Harvard Medical School, Francis St. 75, Boston, 02115, Massachusetts, USA

    Joseph Loscalzo

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Totzeck, M., Kelm, M., Rassaf, T. (2011). Dietary Flavonoids as Modulators of NO Bioavailability in Acute and Chronic Cardiovascular Diseases. In: Bryan, N., Loscalzo, J. (eds) Nitrite and Nitrate in Human Health and Disease. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60761-616-0_8

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