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Redox-Related Genetic Markers of Cardiovascular Diseases

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Studies on Cardiovascular Disorders

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Abstract

Multiple factors contribute to the development of cardiovascular diseases, with oxidative stress being one of the most important pathogenetic mechanisms. Redox-related genes are therefore attractive candidate genes for cardiovascular diseases. There is compelling evidence that polymorphisms of genes that are related to production of and defences against reactive oxygen species are associated with levels of free radicals and intermediate cardiovascular phenotypes. Less robust data are available for the relationship between variants of redox-related genes and advanced cardiovascular diseases such as coronary artery disease. Reasons for these negative findings are the complexity of the disease and insufficient characterisation of the phenotype and environmental factors. Large-scale genome-wide association studies are expected to deliver results on the role of redox-related genes in the pathogenesis of cardiovascular diseases, but future strategies will also involve more systematic and integrative approaches, including transcriptomic, proteomic, and metabolomic strategies.

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Authors and Affiliations

  1. BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, Scotland, UK

    Christian Delles & Anna F. Dominiczak

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  1. Christian Delles
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  2. Anna F. Dominiczak
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Correspondence to Christian Delles .

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Editors and Affiliations

  1. Physiologisches Institut, Universität Gießen, Aulweg 129, Gießen, 35392, Germany

    Heinrich Sauer

  2. James Black Centre, King's College, London, Coldharbour Lane 125, London, SE5 9NU, United Kingdom

    Ajay M. Shah

  3. Fac. Medicina, Instituto do Coração (INCOR), Universidade de São Paulo, Av. Enéas de Carvalho Aguiar 44, São Paulo, 05403-000, São Paulo, Brazil

    Francisco R. M. Laurindo

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Delles, C., Dominiczak, A.F. (2010). Redox-Related Genetic Markers of Cardiovascular Diseases. In: Sauer, H., Shah, A., Laurindo, F. (eds) Studies on Cardiovascular Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-600-9_10

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