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Alternative Donor Hematopoietic Stem Cell Transplantation: A Role for Umbilical Cord Blood Transplantation for Hematologic Malignancies

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Book cover Leukemia and Related Disorders

Part of the book series: Contemporary Hematology ((CH))

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Abstract

Hematopoietic stem cell transplantation (HSCT) is a widely accepted therapy with potentially curative benefit for patients with benign and malignant hematologic disorders. There are currently three possible sources of allogeneic hematopoietic stem cells (HSCs) – bone marrow, granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood (PBSC), and umbilical cord blood (CB). Donors can be either related or unrelated and must match recipients at human leukocyte antigens (HLA). Based on the average size of American families, and the 25% probability that a given sibling pair will be HLA-matched, it is estimated that approximately 35% of persons in the United States will have an HLA-matched sibling.

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Author information

Authors and Affiliations

  1. Division of Hematology, University of Washington School of Medicine, 825 Eastlake Ave E, Seattle, WA, 98109, USA

    Laura F. Newell M.D.

  2. Department of Medical Oncology, University of Colorado School of Medicine, 1665 Aurora Court, Room 2251A, Aurora, CO, 80045, USA

    Jonathan A. Gutman M.D.

  3. Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA

    Colleen Delaney M.D., M.Sc.

  4. Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2-100, Seattle, WA, 98109, USA

    Colleen Delaney M.D., M.Sc.

Authors
  1. Laura F. Newell M.D.
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  2. Jonathan A. Gutman M.D.
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  3. Colleen Delaney M.D., M.Sc.
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Corresponding author

Correspondence to Colleen Delaney M.D., M.Sc. .

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Editors and Affiliations

  1. Univ of Washington School of Medicine, Member,, Professor of Med, Division of Hematology, Attending Physician, Seattle Cancer Care Alliance, Seattle, 98109-1024, Washington, USA

    Elihu H. Estey

  2. Director, Clinical Research Division,, Fred Hutchinson Cancer Research Center, Professor of Medicine; Head of Oncology, Seattle Cancer Care Alliance, Univ of Washington Sch of Med, Seattle, 98109-1024, Washington, USA

    Fred R. Appelbaum

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Newell, L.F., Gutman, J.A., Delaney, C. (2012). Alternative Donor Hematopoietic Stem Cell Transplantation: A Role for Umbilical Cord Blood Transplantation for Hematologic Malignancies. In: Estey, E., Appelbaum, F. (eds) Leukemia and Related Disorders. Contemporary Hematology. Springer, New York, NY. https://doi.org/10.1007/978-1-60761-565-1_8

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