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Endocrine Disruptors and Puberty pp 201–224Cite as

Developmental Exposure to Environmental Endocrine Disruptors and Adverse Effects on Mammary Gland Development

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

The breast or mammary gland is an organ highly dependent upon hormones and other endogenous growth catalysts for normal development. Environmental chemical exposures have been associated with altered breast developmental timing in populations of girls, and several chemicals and dietary agents are known to induce delayed or accelerated mammary gland development in rodent models. These alterations in development are more likely to occur if exposure to endocrine disruptors coincides with periods of rapid cellular proliferation. These periods of growth include prenatal, peripubertal, and pregnant/lactational mammary development. This chapter will outline the studies that have shown significant effects of environmental chemicals on mammary gland development in rodent models and discuss the relationship of these data to later life adverse health repercussions.

Funding Information: Support for L. Beck and A. Borde was provided through the NIH Summers of Discovery Program, with funding by the National Toxicology Program and the American Recovery and Reinvestment Act.

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Author information

Authors and Affiliations

  1. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA

    Suzanne E. Fenton

  2. Summers of Discovery Internship Program, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA

    Lydia M. Beck & Aditi R. Borde

  3. School of Medicine, University of Missouri, Columbia, MO, USA

    Lydia M. Beck

  4. SRC Inc., Arlington, VA, USA

    Jennifer L. Rayner

Authors
  1. Suzanne E. Fenton
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  2. Lydia M. Beck
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  3. Aditi R. Borde
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  4. Jennifer L. Rayner
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Corresponding author

Correspondence to Suzanne E. Fenton .

Editor information

Editors and Affiliations

  1. Sotiria Hospital, Medical School University of Athens, Third Department of Medicine, Athens, 145 78, Greece

    Evanthia Diamanti-Kandarakis

  2. Pharmacology & Toxicology, College of Pharmacy, Gustavus & Louise Pfeiffer Professor, University of Texas at Austin, Austin, 78712, Texas, USA

    Andrea C. Gore

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Disclaimer: The information in this document has been subjected to review by the National Institute for Environmental Health Sciences and approved for publication. The interpretations and conclusions in this review are those of the authors. Approval does not signify that the contents reflect the views of the Institute, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

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Fenton, S.E., Beck, L.M., Borde, A.R., Rayner, J.L. (2012). Developmental Exposure to Environmental Endocrine Disruptors and Adverse Effects on Mammary Gland Development. In: Diamanti-Kandarakis, E., Gore, A. (eds) Endocrine Disruptors and Puberty. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-60761-561-3_7

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