Abstract
Idiopathic gastroparesis is a disorder of delayed gastric emptying without an identifiable cause. Several series of patients with gastroparesis found idiopathic gastroparesis to be the most common cause of gastroparesis, comprising 36–49% of patients. Up to 23% of patients with idiopathic gastroparesis may have a postinfectious form of gastroparesis, presenting after a viral prodrome and acute onset of symptoms. Patients with postinfectious gastroparesis typically have a better prognosis compared to those with idiopathic gastroparesis. Some patients with postinfectious gastroparesis have been reported to experience symptom improvement and even resolution of symptoms anywhere from 1 to 32 months after the onset of symptoms.
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Soykan I, Sivri B, Sarosiek I, Kiernan B, McCallum RW. Demography, clinical characteristics, psychological and abuse profiles, treatment, and long-term follow-up of patients with gastroparesis. Dig Dis Sci. 1998;43(11):2398–404.
Jung HK, Choung RS, Locke 3rd GR, et al. The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006. Gastroenterology. 2009;136(4):1225–33.
Bielefeldt K, Raza N, Zickmund SL. Different faces of gastroparesis. World J Gastroenterol. 2009;15(48):6052–60.
Bityutskiy LP, Soykan I, McCallum RW. Viral gastroparesis: a subgroup of idiopathic gastroparesis-clinical characteristics and long-term outcomes. Am J Gastroenterol. 1997;92(9):1501–4.
Oh JJ, Kim CH. Gastroparesis after a presumed viral illness: clinical and laboratory features and natural history. Mayo Clin Proc. 1990;65(5):636–42.
Naftali T, Yishai R, Zangen T, Levine A. Post-infectious gastroparesis: clinical and electerogastrographic aspects. J Gastroenterol Hepatol. 2007;22(9):1423–8.
Wang YR, Fisher RS, Parkman HP. Gastroparesis-related hospitalizations in the United States: trends, characteristics, and outcomes, 1995–2004. Am J Gastroenterol. 2008;103(2):313–22.
Pasricha PJ, Mannalithara A, Mithal A, Sehgal A, Morton JM, Singh G. Gastroparesis hospitalizations in the US: non-diabetic gastroparesis is a distinct and more serious health problem than diabetic gastroparesis. Gastroenterology. 2008;134(4, Supplement 1):A-537. Abstract.
Parkman HP, Yates K, Hasler WL et al. Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gatroparesis severity. Gastroenterology 2011;140(1):101–15.
Hasler WL, Parkman HP, Wilson LA, et al. Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis. Am J Gastroenterol. 2010;105(11):2357–67.
Yuan CS, Foss JF, O’Connor M, Roizen MF, Moss J. Effects of low-dose morphine on gastric emptying in healthy volunteers. J Clin Pharmacol. 1998;38(11):1017–20.
Parkman HP, Trate DM, Knight LC, Brown KL, Maurer AH, Fisher RS. Cholinergic effects on human gastric motility. Gut. 1999;45(3):346–54.
Bouras EP, Talley NJ, Camilleri M, et al. Effects of amitriptyline on gastric sensorimotor function and postprandial symptoms in healthy individuals: a randomized, double-blind, placebo-controlled trial. Am J Gastroenterol. 2008;103(8):2043–50.
Yavorski RT, Hallgren SE, Blue PW. Effects of verapamil and diltiazem on gastric emptying in normal subjects. Dig Dis Sci. 1991;36(9):1274–6.
Robertson DR, Renwick AG, Wood ND, et al. The influence of levodopa on gastric emptying in man. Br J Clin Pharmacol. 1990;29(1):47–53.
Gritz ER, Ippoliti A, Jarvik ME, et al. The effect of nicotine on the delay of gastric emptying. Aliment Pharmacol Therap. 1988;2(2):173–8.
Quartero AO, de Wit NJ, Lodder AC, Numans ME, Smout AJ, Hoes AW. Disturbed solid-phase gastric emptying in functional dyspepsia: a meta-analysis. Dig Dis Sci. 1998;43(9):2028–33.
Talley NJ, Locke 3rd GR, Lahr BD, et al. Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut. 2006;55(7):933–9.
Talley NJ, Verlinden M, Jones M. Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia? Am J Gastroenterol. 2001;96(5):1422–8.
Talley NJ, Verlinden M, Snape W, et al. Failure of a motilin receptor agonist (ABT-229) to relieve the symptoms of functional dyspepsia in patients with and without delayed gastric emptying: a randomized double-blind placebo-controlled trial. Aliment Pharmacol Therapeut. 2000;14(12):1653–61.
Arts J, Caenepeel P, Verbeke K, Tack J. Influence of erythromycin on gastric emptying and meal related symptoms in functional dyspepsia with delayed gastric emptying. Gut. 2005;54(4):455–60.
Cherian D, Sachdeva P, Fisher RS, Parkman HP. Abdominal pain is a frequent symptom of gastroparesis. Clin Gastroenterol Hepatol. 2010;8(8):676–81.
Karamanolis G, Caenepeel P, Arts J, Tack J. Determinants of symptom pattern in idiopathic severely delayed gastric emptying: gastric emptying rate or proximal stomach dysfunction? Gut. 2007;56(1):29–36.
Hoogerwerf WA, Pasricha PJ, Kalloo AN, Schuster MM. Pain: the overlooked symptom in gastroparesis. Am J Gastroenterol. 1999;94(4):1029–33.
Harrell SP, Studts JL, Dryden GW, Eversmann J, Cai L, Wo JM. A novel classification scheme for gastroparesis based on predominant-symptom presentation. J Clin Gastroenterol. 2008;42(5):455–9.
Camilleri M, Malagelada JR, Brown ML, Becker G, Zinsmeister AR. Relation between antral motility and gastric emptying of solids and liquids in humans. Am J Physiol. 1985;249(5 Pt 1): G580–5.
Kerlin P. Postprandial antral hypomotility in patients with idiopathic nausea and vomiting. Gut. 1989;30(1):54–9.
Camilleri M, Brown ML, Malagelada JR. Relationship between impaired gastric emptying and abnormal gastrointestinal motility. Gastroenterology. 1986;91(1):94–9.
Mearin F, Camilleri M, Malagelada JR. Pyloric dysfunction in diabetics with recurrent nausea and vomiting. Gastroenterology. 1986;90(6):1919–25.
Shetler K, Nguyen L, Bunker S, Parker S, Snape WJ. Role of pyloric pressures and botulinum toxin injection in the treatment of diabetic and idiopathic gastroparesis. Gastroenterology. 2006;130(4):A-129 (abstract).
Miller LS, Szych GA, Kantor SB, et al. Treatment of idiopathic gastroparesis with injection of botulinum toxin into the pyloric sphincter muscle. Am J Gastroenterol. 2002;97(7):1653–60.
Ezzeddine D, Jit R, Katz N, Gopalswamy N, Bhutani MS. Pyloric injection of botulinum toxin for treatment of diabetic gastroparesis. Gastrointest Endosc. 2002;55(7):920–3.
Lacy BE, Crowell MD, Schettler-Duncan A, Mathis C, Pasricha PJ. The treatment of diabetic gastroparesis with botulinum toxin injection of the pylorus. Diabetes Care. 2004;27(10):2341–7.
Bromer MQ, Friedenberg F, Miller LS, Fisher RS, Swartz K, Parkman HP. Endoscopic pyloric injection of botulinum toxin A for the treatment of refractory gastroparesis. Gastrointest Endosc. 2005;61(7):833–9.
Friedenberg FK, Palit A, Parkman HP, Hanlon A, Nelson DB. Botulinum toxin a for the treatment of delayed gastric emptying. Am J Gastroenterol. 2008;103(2):416–23.
Arts J, Holvoet L, Caenepeel P, et al. Clinical trial: a randomized-controlled crossover study of intrapyloric injection of botulinum toxin in gastroparesis. Aliment Pharmacol Therapeut. 2007;26(9):1251–8.
Coleski R, Anderson MA, Hasler WL. Factors associated with symptom response to pyloric injection of botulinum toxin in a large series of gastroparesis patients. Dig Dis Sci. 2009;54(12):2634–42.
Maranki JL, Lytes V, Meilahn JE, et al. Predictive factors for clinical improvement with Enterra gastric electric stimulation treatment for refractory gastroparesis. Dig Dis Sci. 2008;53(8):2072–8.
Anand C, Al-Juburi A, Familoni B, et al. Gastric electrical stimulation is safe and effective: a long-term study in patients with drug-refractory gastroparesis in three regional centers. Digestion. 2007;75(2–3):83–9.
Lin Z, Sarosiek I, Forster J, McCallum RW. Symptom responses, long-term outcomes and adverse events beyond 3 years of high-frequency gastric electrical stimulation for gastroparesis. Neurogastroenterol Motil. 2006;18(1):18–27.
Abell T, McCallum R, Hocking M et al. Gastric electrical stimulation for medically refractory gastroparesis. Gastroenterology. 2003;125(2):421–8.
Musunuru S, Beverstein G, Gould J. Preoperative predictors of significant symptomatic response after 1 year of gastric electrical stimulation for gastroparesis. World J Surg. 2010;34(8):1853–8.
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Nguyen, L. (2012). Idiopathic Gastroparesis. In: Parkman, H., McCallum, R. (eds) Gastroparesis. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-60761-552-1_18
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DOI: https://doi.org/10.1007/978-1-60761-552-1_18
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