Abstract
The Pathogen Molecular Genetics Section of the Laboratory of Human Bacterial Pathogenesis investigates the molecular basis of pathogenesis in staphylococci, focusing on the two most important staphylococcal pathogens, Staphylococcus aureus and S. epidermidis. Research projects include mechanisms of staphylococci to evade human innate host defense such as toxin production and biofilm formation and virulence gene regulation. In addition, recent studies have given important insight into the molecular underpinnings of the exceptional pathogenic potential of community-associated methicillin-resistant S. aureus.
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References
Diep B A, Palazzolo-Ballance A M, Tattevin P & et al (2008). Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis PLoS ONE, 3, e3198
Kennedy A D, Otto M, Braughton K R & et al (2008) Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification, Proc Natl Acad Sci U.S.A., 105, 1327–1332
Kocianova S, Vuong C, Yao Y & et al (2005). Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis, J Clin Invest, 115, 688–694
Labandeira-Rey M, Couzon F, Boisset S & et al (2007). Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia, Science, 315, 1130–1133
Lai Y, Villaruz A E, Li M & et al (2007). The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci, Mol Microbiol, 63, 497–506
Li M, Cha D J, Lai Y & et al (2007). The antimicrobial peptide-sensing system aps of Staphylococcus aureus, Mol Microbiol, 66, 1136–1147
Li M, Diep B A, Villaruz A E & et al (2009). Evolution of virulence in epidemic community-associated MRSA, Proc Natl Acad Sci USA, 106, 5883–5888
Li M, Lai Y, Villaruz A E, Cha D J & et al (2007). Gram-positive three-component antimicrobial peptide-sensing system, Proc Natl Acad Sci USA, 104, 9469–9474
Li M, Villaruz A E, Vadyvaloo V & et al (2008). AI-2-dependent gene regulation in Staphylococcus epidermidis, BMC Microbiol, 8, 4
Montgomery C P & Daum R S (2009). Transcription of inflammatory genes in the lung after infection with community-associated methicillin-resistant Staphylococcus aureus: a role for Panton-Valentine Leukocidin? Infect Immun, 77, 2159–2167
Queck S Y, Jameson-Lee M, Villaruz A E & et al (2008). RNAIII-Independent Target Gene Control by the agr Quorum-Sensing System: Insight into the Evolution of Virulence Regulation in Staphylococcus aureus, Mol Cell, 32, 150–158
Villaruz A E, Bubeck Wardenburg J, Khan B A & et al (2009). A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation, J Infect Dis, 200, 724–734
Voyich J M, Otto M, Mathema B & et al (2006). Is Panton- Valentine leukocidin the major virulence determinant in community-associated methicillin- resistant Staphylococcus aureus disease? J Infect Dis, 194, 1761–1770
Vuong C, Gerke C, Somerville G A & et al (2003). Quorum-sensing control of biofilm factors in Staphylococcus epidermidis, J Infect Dis, 188, 706–718
Vuong C, Kocianova S, Voyich J M & et al (2004). A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence, J Biol Chem, 279, 54881–54886
Vuong C, Kocianova S, Yao Y & et al (2004). Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo, J Infect Dis, 190, 1498–1505
Vuong C, Saenz H L, Gotz F & et al (2000). Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus, J Infect Dis, 182, 1688–1693
Vuong C, Voyich J M, Fischer E R & et al (2004). Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system, Cell Microbiol, 6, 269–675
Wang L, Li M, Dong D, Bach TH & et al (2008). SarZ is a key regulator of biofilm formation and virulence in Staphylococcus epidermidis, J. Infect Dis, 197, 1254–1262
Wang R, Braughton K R, Kretschmer D & et al (2007). Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA, Nat Med, 13, 1510–1514
Wardenburg JB, Bae T, Otto M & et al (2007). Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia, Nat Med, 13, 1405–1406
Xu L, Li H, Vuong C & et al (2006). Role of the luxS quorum-sensing system in biofilm formation and virulence of Staphylococcus epidermidis, Infect Immun, 74, 488–496
Yao Y, Sturdevant D E & Otto M (2005). Genomewide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into the pathophysiology of S. epidermidis biofilms and the role of phenol-soluble modulins in formation of biofilms, J Infect Dis, 191, 289–298
Yao Y, Vuong C, Kocianova S & et al (2006). Characterization of the Staphylococcus epidermidis accessory-gene regulator response: quorum-sensing regulation of resistance to human innate host defense, J Infect Dis, 193, 841–848
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Otto, M. (2010). Molecular Biology of Staphylococcal Pathogenesis. In: Georgiev, V. (eds) National Institute of Allergy and Infectious Diseases, NIH. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-512-5_10
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DOI: https://doi.org/10.1007/978-1-60761-512-5_10
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