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The Role of Classical Transient Receptor Potential Channels in the Regulation of Hypoxic Pulmonary Vasoconstriction

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Book cover Membrane Receptors, Channels and Transporters in Pulmonary Circulation

Part of the book series: Advances in Experimental Medicine and Biology ((volume 661))

Abstract

Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism of the lung matching blood perfusion to ventilation during local alveolar hypoxia. HPV thus optimizes pulmonary gas exchange. In contrast chronic and generalized hypoxia leads to pulmonary vascular remodeling with subsequent pulmonary hypertension and right heart hypertrophy. Among other non-selective cation channels, the family of classical transient receptor potential channels (TRPC) has been shown to be expressed in pulmonary arterial smooth muscle cells. Among this family, TRPC6 is essential for the regulation of acute HPV in mice. Against this background, in this chapter we give an overview about the TRPC family and their role in HPV.

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Author information

Authors and Affiliations

  1. University of Giessen Lung Center (UGLC), Justus-Liebig-University Giessen, Giessen, Germany

    B. Fuchs, F. Grimminger & N. Weissmann

  2. Institute for Pharmacology and Toxicology, University of Marburg, Marburg, Germany

    A. Dietrich & H. Kalwa

  3. Walter-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University Munich, Munich, Germany

    T. Gudermann

Authors
  1. B. Fuchs
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  2. A. Dietrich
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  3. T. Gudermann
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  4. H. Kalwa
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  5. F. Grimminger
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  6. N. Weissmann
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Editor information

Editors and Affiliations

  1. Departments of Medicine and Pharmacology, University of Illinois at Chicago, Chicago, 60612, USA

    Jason X. -J. Yuan

  2. Guy’s Hospital Campus, Dept. Physiology, King’s College London, London, SE1 1UL, United Kingdom

    Jeremy P. T. Ward

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Fuchs, B., Dietrich, A., Gudermann, T., Kalwa, H., Grimminger, F., Weissmann, N. (2010). The Role of Classical Transient Receptor Potential Channels in the Regulation of Hypoxic Pulmonary Vasoconstriction. In: Yuan, JJ., Ward, J. (eds) Membrane Receptors, Channels and Transporters in Pulmonary Circulation. Advances in Experimental Medicine and Biology, vol 661. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-500-2_12

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