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The IgE Antibody and Its Use in Cancer Immunotherapy

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Book cover Cancer and IgE

Abstract

The immunoglobulin E (IgE) is a class of antibody that is capable of mounting a robust immune response resulting in anaphylaxis, which plays a central role in allergic reactions against environmental agents and immunity against parasites. Multiple studies also suggest that IgE plays a role in cancer immunosurveillance, which implies that this class of antibody can be exploited for the treatment of cancer. While most therapeutic antibodies developed for cancer therapy are of the IgG class, IgE has several advantages including the exceptionally high affinity for its Fc receptors (FcɛRs) and its low serum concentration that provides less competition for Fc receptor occupancy. In addition, FcɛRs are expressed on relevant effector cells involved in antibody-dependent cell-mediated cytotoxicity (ADCC) and/or antibody-dependent cell-mediated phagocytosis (ADCP) including antigen-presenting cells (APC). In fact, multiple IgEs targeting different tumor-associated antigens (TAA) have been developed and shown to be effective against cancer cells in vitro and in animal models. Further advances of current technologies and experimental models, coupled with a better understanding of IgE-mediated immune effector mechanisms against targeted tumors, are expected to help elucidate the full potential of tumor-specific IgE antibodies for cancer immunotherapy.

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Acknowledgments

This work was supported by NIH/NCI grants R01CA107023, R01 supplements CA107023-02S1 and CA57152-13S1, NIH/NCI T32-CA009120, NIH Fogarty AITRP-AIDS Malignancies Program D43-TW000013-S1, the Susan G. Komen Breast Cancer Foundation Basic, Clinical and Translational Research Grant BCTR0706771, Cancer Research Coordinating Committee (CRCC), the Howard Hughes Medical Institute (HHMI) Gilliam Fellowship, and the Whitcome Fellowship of the Molecular Biology Interdepartmental PhD Program (MBIDP) at UCLA.

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, University of California, Los Angeles, CA, USA

    Tracy R. Daniels, Elizabeth Ortiz-Sánchez & Gustavo Helguera

  2. Division of Surgical Oncology, Department of Surgery andMolecular Biology Institute, University of California, Los Angeles, CA, USA

    José A. Rodríguez

  3. Division of Surgical Oncology, Department of Surgery and Department of Microbiology, Immunology, and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA

    Manuel L. Penichet

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Correspondence to Manuel L. Penichet .

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  1. David Geffen School of Medicine, University of California, Los Angeles, Le Conte Ave. 10833, Los Angeles, 90095, U.S.A.

    Manuel L. Penichet

  2. Zentrum für Physiologie,, Medizinische Universität Wien, Währinger Gürtel 18-20, Wien, 1090, Austria

    Erika Jensen-Jarolim

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Daniels, T.R., Rodríguez, J.A., Ortiz-Sánchez, E., Helguera, G., Penichet, M.L. (2010). The IgE Antibody and Its Use in Cancer Immunotherapy. In: Penichet, M., Jensen-Jarolim, E. (eds) Cancer and IgE. Humana Press. https://doi.org/10.1007/978-1-60761-451-7_7

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