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Mast Cells in Allergy and Tumor Disease

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Cancer and IgE

Abstract

In allergy, mast cells (MCs) are known for the notoriously detrimental role they play. MC mediators like histamine, prostaglandins, leukotrienes and thromboxane are released during the early phase of an allergic reaction and produce inflammation and local tissue responses. One pervasive roadblock in the effective development of therapeutic immunity to cancer is the fact that tumors create immune privileged sites that are resistant to the development of effective inflammation and effective anti-tumor responses. In this chapter we will present the current knowledge of the inflammatory responses elicited in allergies by IgE and MCs as well as the current knowledge on how the responses of MCs may regulate tumor growth and the immune response to tumors.

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Notes

  1. 1.

    Anna Wasiuk and Victor C. de Vries contributed equally to this manuscript.

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  1. Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA

    Anna Wasiuk, Victor C. de Vries, Elizabeth C. Nowak & Randolph J. Noelle

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  1. David Geffen School of Medicine, University of California, Los Angeles, Le Conte Ave. 10833, Los Angeles, 90095, U.S.A.

    Manuel L. Penichet

  2. Zentrum für Physiologie,, Medizinische Universität Wien, Währinger Gürtel 18-20, Wien, 1090, Austria

    Erika Jensen-Jarolim

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Wasiuk, A., de Vries, V.C., Nowak, E.C., Noelle, R.J. (2010). Mast Cells in Allergy and Tumor Disease. In: Penichet, M., Jensen-Jarolim, E. (eds) Cancer and IgE. Humana Press. https://doi.org/10.1007/978-1-60761-451-7_6

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