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Amyloid and Related Disorders pp 105–110Cite as

Cerebrovascular Amyloidoses

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Part of the book series: Current Clinical Pathology ((CCPATH))

Abstract

The most recognizable and common cerebral nervous system amyloidosis is Alzheimer’s disease (AD) in its familiar or sporadic forms. In AD, amyloid is formed from the processing of the amyloid β precursor protein (AβPP), termed amyloid β (Aβ). There are also other types of Aβ pathology in the central nervous system that can be distinct from AD and dementia. Moreover, a number of other proteins (prions, cystatin C, gelsolin, transthyretin, immunoglobulin light chains, and BriPP) can lead to amyloidosis of the cerebral nervous system, although they are rare. Some of these proteins have mutations that cause cerebral amyloid angiopathy, resulting in hemorrhages with or without dementia. Amyloid derived from immunoglobulin light chains, AL, can be produced by intracerebral amyloidomas mimicking tumors. Finally, there are systemic amyloidoses that secondarily can involve the superficial leptomeningeal vessels and the eye. Amyloid deposition in the eyes may cause vitreous opacity, keratoconjunctivitis, glaucoma, or lattice corneal dystrophy. Amyloid deposits in the pituitary are associated with aging or adenomas.

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Authors and Affiliations

  1. Department of Pathology, Loyola University Medical Center, LUMC Tissue Repository, Bldg#110, Rm#2242, 2160 S. First Avenue, Maywood, IL, 60153, USA

    John M. Lee M.D., Ph.D.

  2. Department of Pathology, Loyola University Medical Center, Bldg#110, Rm#2242, 2160 S. First Avenue, Maywood, IL, 60153, USA

    Maria M. Picken M.D., Ph.D., F.A.S.N.

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  1. John M. Lee M.D., Ph.D.
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  2. Maria M. Picken M.D., Ph.D., F.A.S.N.
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Corresponding author

Correspondence to Maria M. Picken M.D., Ph.D., F.A.S.N. .

Editor information

Editors and Affiliations

  1. Bldg#110, Rm#2242, Department of Pathology, Loyola University Medical Center, S. First Avenue 2160, Maywood, 60153, Illinois, USA

    Maria M. Picken MD, PhD, FASN

  2. , Department of Laboratory Medicine and Pa, Mayo Clinic, First Street SW 200, Rochester, 55905, USA

    Ahmet Dogan, M.D., Ph.D.

  3. , Department of Renal Pathology, Bostwick Laboratories, Lake Ellenor Dr. 8001, Orlando, 32809, Florida, USA

    Guillermo A. Herrera, M.D.

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Lee, J.M., Picken, M.M. (2012). Cerebrovascular Amyloidoses. In: Picken MD, PhD, FASN, M., Dogan, M.D., Ph.D., A., Herrera, M.D., G. (eds) Amyloid and Related Disorders. Current Clinical Pathology. Humana Press. https://doi.org/10.1007/978-1-60761-389-3_7

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  • DOI: https://doi.org/10.1007/978-1-60761-389-3_7

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-388-6

  • Online ISBN: 978-1-60761-389-3

  • eBook Packages: MedicineMedicine (R0)

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