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Exercise Genomics pp 101–128Cite as

The Interaction Between Genetic Variation and Exercise and Physical Activity in the Determination of Body Composition and Obesity Status

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Part of the book series: Molecular and Translational Medicine ((MOLEMED))

Abstract

Obesity, currently affecting more than one third of all adults in the United States, is a complex disease with a multifactorial etiology involving genetic and environmental factors. Public health prevention programs designed to reduce the risk and occurrence of obesity and overweight commonly focuses on modifiable environments and behaviors such as diet and physical activity with varied results among individuals. This heterogeneity in response to body weight interventions is at least in part of genetic origin. While it is widely accepted, genetic variation plays a substantial role in the determination of body composition, fat topography, and obesity outcomes, genetic factors can also affect an individual’s response to changes in environments such as nutrition and physical activity. The present chapter examines the complex relationships between physical activity/exercise behaviors and genetic variation in genes related to body mass and composition in the determination of body fatness and obesity.

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Authors and Affiliations

  1. Department of Epidemiology, University of Alabama at Birmingham, 1530 3rd Avenue S, 35294, Birmingham, AL, USA

    Molly S. Bray

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  1. Mary H. Sailors
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  2. Molly S. Bray
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  1. Dept. Kinesiology, Human Performance Lab., University of Connecticut, 2095 Hillside Rd, U-1110, Storrs, 06269-1110, Connecticut, USA

    Linda S. Pescatello

  2. University of Maryland, Department of Kinesiology, School of Public Health, College Park, 20742-2611, Maryland, USA

    Stephen M. Roth

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Sailors, M.H., Bray, M.S. (2011). The Interaction Between Genetic Variation and Exercise and Physical Activity in the Determination of Body Composition and Obesity Status. In: Pescatello, L., Roth, S. (eds) Exercise Genomics. Molecular and Translational Medicine. Humana Press. https://doi.org/10.1007/978-1-60761-355-8_5

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