Abstract
Cutaneous lymphoproliferative disorders are a markedly heterogeneous group of diseases and represent one of the most challenging areas in dermatopathology. Careful correlation of clinical, histopathological, immunophenotypic, and molecular findings is essential for the accurate diagnosis and proper classification of these neoplasms [1]. There are several types of B-cell lymphoma which may show skin involvement, either primarily or as a secondary manifestation [2, 3]. While the vast majority of nodal/systemic lymphomas are of B-cell lineage [4, 5], primary cutaneous B-cell neoplasms represent only a minority of all primary cutaneous lymphomas [2, 3]. Primary cutaneous lymphomas often demonstrate different clinical behaviors, prognoses, and responses to therapy as compared with systemic/nodal lesions of similar lineage with secondary skin involvement [2, 3]. This is particularly true for cutaneous B-cell lymphomas [2, 3]. Appropriate staging at the time of diagnosis is necessary for accurate classification of a neoplastic lymphocytic infiltrate in the skin [2, 3].
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Acknowledgments
Our sincere gratitude to Jeffrey Sklar, M.D., for his invaluable assistance with the images of molecular tests.
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Subtil, A. (2011). Cutaneous B-Cell Lymphomas. In: Murphy, M. (eds) Molecular Diagnostics in Dermatology and Dermatopathology. Current Clinical Pathology. Humana Press. https://doi.org/10.1007/978-1-60761-171-4_12
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DOI: https://doi.org/10.1007/978-1-60761-171-4_12
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