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Proteomics in the Vitreous of Diabetic Retinopathy Patients

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Visual Dysfunction in Diabetes

Part of the book series: Ophthalmology Research ((OPHRES))

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Abstract

Vision loss cause by diabetic retinopathy is primarily associated with advanced stages of this disease, including proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME). While abnormalities in microvascular functions and structure appear central to the progression of diabetic retinopathy, the specific factors that modulate the transition to the advanced sight-threatening stages of this disease are not fully understood. Moreover, since animal models do not reproduce many of the specific pathologies associated with PDR and DME, further characterization of ocular biochemical changes from patients with diabetic retinopathy is needed to identify factors that could be associated with the advance stages of this disease and vision loss.

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Acknowledgments

This work was supported in part by the US National Institutes of Health (grants EY019029, DK 36836) and the Juvenile Diabetes Research Foundation.

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Authors and Affiliations

  1. Joslin Diabetes Center, Boston, MA, USA

    Edward P. Feener

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  1. Edward P. Feener
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Correspondence to Edward P. Feener .

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Editors and Affiliations

  1. Milton S. Hershey Medical Center, Dept. Neural and Behavioral Sciences, Penn State College of Medicine, University Drive 500, Hershey, 17033, Pennsylvania, USA

    Joyce Tombran-Tink

  2. Milton S. Hershey Medical Center, Dept. Neural and Behavioral Sciences, Penn State College of Medicine, University Drive 500, Hershey, 17033, Pennsylvania, USA

    Colin J. Barnstable

  3. Molecular and Integrative Physiology, Ophthalmology and Visual Sciences, Kellogg Eye Center, Wall Street 1000, Ann Arbor, 17033-2390, Michigan, USA

    Thomas W. Gardner

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Feener, E.P. (2012). Proteomics in the Vitreous of Diabetic Retinopathy Patients. In: Tombran-Tink, J., Barnstable, C., Gardner, T. (eds) Visual Dysfunction in Diabetes. Ophthalmology Research. Springer, New York, NY. https://doi.org/10.1007/978-1-60761-150-9_11

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  • DOI: https://doi.org/10.1007/978-1-60761-150-9_11

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