Keypoints
-
1.
The auditory system consists of four anatomically separate structures:
-
(a)
those that conduct the stimulus to the receptors
-
(b)
the receptors
-
(c)
the auditory nerve
-
(d)
the central auditory nervous system
-
(a)
-
2.
The most important part regarding tinnitus is the auditory nervous system.
-
3.
The auditory nervous system consists of two parallel ascending pathways that project to auditory cortices and two (reciprocal) descending pathways that project to nuclei of the auditory pathways.
-
4.
The nuclei in the ascending auditory pathways process information in a serial hierarchical fashion, and processing occurs in modules with specific functions.
-
5.
Two separate ascending sensory pathways have been identified in the auditory pathways: classical pathways and the non-classical pathways. Also, the somatosensory and visual pathways have two different ascending tracts.
-
6.
The classical pathways are also known as the lemniscal system, or the specific system, and the non-classical pathways are also known as the extralemniscal system, or the unspecific system. The non-classical pathways have been divided into the defuse system and the polysensory pathways.
-
7.
The classical and non-classical pathways process information differently and have different central targets, especially regarding connections to the thalamus and the cerebral cortex.
-
8.
The non-classical ascending auditory pathways branch off the classical pathways at several levels, the most prominent being the central nucleus of the inferior colliculus.
-
9.
The auditory pathways receive input from the somatosensory system at the external nucleus of the inferior colliculus and from the dorsal cochlear nucleus as well.
-
10.
The auditory pathways are mainly crossed, but there are extensive connections between nuclei at the two sides at two levels: the pontine nuclei (superior olivary complex) and the midbrain level (inferior colliculus). There are also extensive connections between the two sides at the cerebral cortical level.
-
11.
The auditory nerve sends collaterals to cells in all these divisions of the cochlear nucleus. That is the earliest sign of the anatomical basis for parallel processing of information. Parallel processing occurs throughout the ascending pathways by axons branching to connect to more than one group of nerve cells.
-
12.
Descending auditory pathways are abundant, in particular, the cortico-thalamic pathways, but little is known about their function. The descending pathways are largely reciprocal to the ascending pathways. The descending pathways reach as far caudal as the receptors in the cochlea.
-
13.
The classical sensory pathways are interrupted by synaptic contacts with neurons in the ventral parts of the thalamus, which project to the primary sensory cortices.
-
14.
The non-classical sensory pathways use the dorsal and medial thalamus as relay, the neurons of which project to secondary and association cortices thus bypassing the primary sensory cortices.
-
15.
Neurons in the dorsal and medial thalamus make direct (subcortical) connections with other parts of the CNS, such as structures of the limbic system, while the classical sensory systems connect to other parts of the CNS, mainly via association cortices.
-
16.
There are anatomical connections between the upper spinal cord and the dorsal cochlear nucleus and between the caudal trigeminal nucleus and the dorsal cochlear nucleus. There are anatomical connections between the somatosensory system and midbrain nuclei of the non-classical auditory system.
-
17.
Neurons in the nuclei of the classical pathways respond distinctly to specific sensory stimuli and have distinct frequency selectivity.
-
18.
Sound stimulation may increase the firing rate of auditory nerve fibers, but saturation occurs for most fibers at low sound intensities.
-
19.
Periodic sounds cause many nerve fibers to become locked to the waveform of the sound, and consequently, the firing of such fibers becomes time locked to each other. It subsequently causes the discharge of many neurons in the ascending auditory pathways, which then become time locked to each other.
-
20.
Stream segregation implies that different types of information (for example, spatial and object information) are processed in anatomically different parts of the sensory nervous system.
-
21.
Parallel processing allows the same information to be processed in anatomically different parts of the nervous system, while stream segregation implies that different kinds of information are processed in anatomically different structures.
-
22.
Much less is known about the functional role of the non-classical pathways compared to the classical pathways, but neurons of the nuclei of the non-classical pathways respond less distinctly and are broader tuned than cells in the classical pathways and respond to a broad range of stimuli. They also integrate information on wider spatial scales than the classical pathways.
-
23.
Neurons in the nuclei of the classical auditory pathways, up to and including the primary auditory cortex, respond only to one sensory modality (sound) while neurons of higher order cortices (secondary and association cortices) integrate information from several sensory systems and respond to different sensory modalities. This response can be modulated by input from non-sensory brain areas such as the amygdala.
-
24.
Some neurons in the ascending non-classical pathways respond to more than one sensory modality. Their response to sound can be modulated by other sensory input.
-
25.
The non-classical pathways make direct (subcortical) connections from the thalamus to other parts of the CNS, such as structures of the limbic system, while the classical sensory systems connect to other such parts of the CNS mainly via association cortices.
-
26.
Stimulation of the somatosensory system affects perception of sounds in children, indicating involvement of the non-classical auditory system in children.
-
27.
There are no signs of cross-modal interaction in adults, except with some forms of tinnitus and in autistic individuals, indicating that the non-classical auditory pathways are not normally active in adults.
-
28.
Sensory systems connect to motor systems, the limbic system, reticular activating system, and the autonomic nervous system through subcortical and cortical routes.
-
29.
There is considerable interaction between different systems in the brain, such as between different sensory systems and between sensory systems and non-sensory systems.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
Some authors use the term “ganglion” for the trigeminal nucleus, but it seems more appropriate to use the term “nucleus” for clusters of nerve cells where synaptic communication occurs. The word “ganglion” should be reserved for clusters of cell bodies, such as the dorsal root ganglia. This is in accordance with the definitions by Stedman’s Electronic Medical Dictionary: A ganglion is: originally, any group of nerve cell bodies in the central or peripheral nervous system; currently, an aggregation of nerve cell bodies located in the peripheral nervous system.
- 2.
In neuroanatomy, a nucleus is a group of nerve cell bodies in the brain or spinal cord that can be demarcated from neighboring groups on the basis of either differences in cell type or the presence of a surrounding zone of nerve fibers or cell-poor neuropil.
Abbreviations
- AAF:
-
Anterior auditory (cortical) field
- AES:
-
Anterior ectosylvian sulcus area
- AI:
-
Primary auditory cortex
- AII:
-
Secondary auditory cortex
- AN:
-
Auditory nerve
- AVCN:
-
Anterior ventral cochlear nuclei
- C2 :
-
Upper segment of the cervical spine
- CN:
-
Cochlear nucleus
- COCB:
-
Crossed olivocochlear bundle
- DC:
-
Dorsal cortex (of IC)
- DNLL:
-
Dorsal nucleus of the lateral lemniscus
- DPOAE:
-
Distortion product otoacoustic emission
- DRG:
-
Dorsal root ganglion
- DZ:
-
Dorsal auditory zone
- ED:
-
Posterior ectosylvian gyrus dorsal part
- EI:
-
Posterior ectosylvian
- EV:
-
Posterior ectosylvian gyrus
- IC:
-
Inferior colliculus
- ICC:
-
Central nucleus of the IC
- ICX:
-
External nucleus of the IC
- IHC:
-
Inner hair cells
- In:
-
Insular
- LL:
-
Lateral lemniscus
- LSO:
-
Lateral superior olive
- MG:
-
Medial geniculate body
- MSO:
-
Medial superior olive
- NLL:
-
Nucleus of the lateral lemniscus
- NTB:
-
Nucleus of the trapezoidal body
- OCB:
-
Olivocochlear bundle
- OHC:
-
Outer hair cells
- PAF:
-
Posterior auditory (cortical) field
- PVCN:
-
Posterior ventral cochlear nuclei
- SH:
-
Stria of Held (intermediate stria)
- SM:
-
Stria of Monakow (dorsal stria)
- SOC:
-
Superior olivary complex
- SOE:
-
Spontaneous otoacoustic emission
- Sp5:
-
Trigeminal nucleus
- Te:
-
Temporal cortex
- TEOAE:
-
Transient evoked otoacoustic emissions
- UCOCB:
-
Uncrossed olivocochlear bundle
- Ve:
-
Auditory cortex ventral area
- VNLL:
-
Ventral nucleus of the lateral lemniscus
- VP:
-
Auditory cortex ventral posterior area
References
Møller AR (2006) Hearing: anatomy, physiology, and disorders of the auditory system, 2nd ed. Amsterdam: Academic Press.
Shepherd GM (1994) Neurobiology. New York: Oxford University Press. 760.
Harrison RV and IM Hunter-Duvar, (1988) An anatomical tour of the cochlea, in Physiology of the ear, AF Jahn and J Santos-Sacchi, Editors. Raven Press: New York. 159–71
Møller AR (1988) Evoked potentials in intraoperative monitoring. Baltimore: Williams and Wilkins.
Møller AR (2003) Sensory systems: anatomy and physiology. Amsterdam: Academic Press.
Korsan-Bengtsen MM (1973) Distorted speech audiometry. Acta Otolaryng. Suppl. 310.
Aitkin LM (1986) The auditory midbrain, structure and function in the central auditory pathway. Clifton, NJ: Humana Press.
Aitkin LM, H Dickhaus, W Schult et al (1978) External nucleus of inferior colliculus: auditory and spinal somatosensory afferents and their interactions. J. Neurophysiol. 41:837–47.
Aitkin LM, CE Kenyon and P Philpott (1981) The representation of auditory and somatosensory systems in the external nucleus of the cat inferior colliculus. J. Comp. Neurol. 196:25–40.
Jain R and S Shore (2006) External inferior colliculus integrates trigeminal and acoustic information: unit responses to trigeminal nucleus and acoustic stimulation in the guinea pig. Neurosci. Lett. 395:71–5.
Zhou J and S Shore (2006) Convergence of spinal trigeminal and cochlear nucleus projections in the inferior colliculus of the guinea pig. J. Comp. Neurol. 495:100–12.
Dehmel S, YL Cui and SE Shore (2008) Cross-modal interactions of auditory and somatic inputs in the brainstem and midbrain and their imbalance in tinnitus and deafness. Am. J. Audiol. 17:S193–209.
LeDoux JE (1992) Brain mechanisms of emotion and emotional learning. Curr. Opin. Neurobiol. 2:191–7.
Møller AR and P Rollins (2002) The non-classical auditory system is active in children but not in adults. Neurosci. Lett. 319:41–4.
Møller AR, MB Møller and M Yokota (1992) Some forms of tinnitus may involve the extralemniscal auditory pathway. Laryngoscope 102:1165–71.
Møller AR (2008) Neural plasticity: for good and bad. Progress of Theoretical Physics Supplement No 173:48–65.
Møller AR (2007) Neurophysiologic abnormalities in autism, in New autism research developments , BS Mesmere, Editor. Nova Science Publishers: New York.
Møller AR, JK Kern and B Grannemann (2005) Are the non-classical auditory pathways involved in autism and PDD? Neurol. Res. 27:625–9.
Møller AR (2006) Neural plasticity and disorders of the nervous system. Cambridge: Cambridge University Press.
Pfaller K and J Arvidsson (1988) Central distribution of trigeminal and upper cervical primary afferents in the rat studied by anterograde transport of horseradish peroxidase conjugated to wheat germ agglutinin. J. Comp. Neurol. 268:91–108.
Zhou J and S Shore (2004) Projections from the trigeminal nuclear complex to the cochlear nuclei: a retrograde and anterograde tracing study in the guinea pig. J. Neurosci. Res. 78:901–7.
Kanold PO and ED Young (2001) Proprioceptive information from the pinna provides somatosensory input to cat dorsal cochlear nucleus. J. Neurosci. 21:7848–58.
Li H and N Mizuno (1997) Single neurons in the spinal trigeminal and dorsal column nuclei project to both the cochlear nucleus and the inferior colliculus by way of axon collaterals: a fluorescent retrograde double-labeling study in the rat. Neurosci. Res. 29:135–42.
Shore SE, Z Vass, NL Wys et al (2000) Trigeminal ganglion innervates the auditory brainstem. J. Comp. Neurol. 419: 271–85.
Itoh K, H Kamiya, A Mitani et al (1987) Direct projections from dorsal column nuclei and the spinal trigeminal nuclei to the cochlear nuclei in the cat. Brain Res. 400: 145–50.
Young ED, I Nelken and RA Conley (1995) Somatosensory effects on neurons in dorsal cochlear nucleus. J. Neurophysiol. 73:743–65.
Zhan X, T Pongstaporn and DK Ryugo (2006) Projections of the second cervical dorsal root ganglion to the cochlear nucleus in rats. J. Comp. Neurol. 496:335–48.
Shulman A (1987) External electrical tinnitus suppression: a review. Am. J. Otol. 8:479–84.
Vass Z, SE Shore, AL Nuttall et al (1997) Trigeminal ganglion innervation of the cochlea – a retrograde transport study. Neuroscience 79:605–15.
Marsh RA, CD Grose, JJ Wenstrup et al (1999) A novel projection from the basolateral nucleus of the amygdala to the inferior colliculus in bats. Soc. Neurosci. Abstr. 25:1417.
Winer JA and CC Lee (2007) The distributed auditory cortex. Hear. Res. 229:3–13.
Schucknecht HF (1974) Pathology of the ear. Cambridge, MA: Harvard University Press.
Pickles JO (1988) An Introduction to the physiology of hearing, 2nd ed. London: Academic Press.
Kim S, DR Frisina and RD Frisina (2002) Effects of age on contralateral suppression of distortion product otoacoustic emissions in human listeners with normal hearing. Audiol. Neurootol. 7:348–57.
Büki B, P Avan and O Ribari (1996) The effect of body position on transient otoacoustic emission, in Intracranial and intralabyrinthine fluids, A Ernst, R Marchbanks and M Samii, Editors. Springer Verlag: Berlin. 175–81.
Kiang NYS, T Watanabe, EC Thomas et al (1965) Discharge patterns of single fibers in the cat’s auditory nerve. Cambridge, MA: MIT Press.
Møller AR (1983) Frequency selectivity of phase-locking of complex sounds in the auditory nerve of the rat. Hear. Res. 11:267–84.
Møller AR (1977) Frequency selectivity of single auditory nerve fibers in response to broadband noise stimuli. J. Acoust. Soc. Am. 62:135–42.
Sellick PM, R Patuzzi and BM Johnstone (1982) Measurement of basilar membrane motion in the guinea pig using the Mossbauer technique. J. Acoust. Soc. Am. 72: 131–41.
Guinan Jr. JJ, BE Norris and SS Guinan (1972) Single auditory units in the superior olivary complex. II. Location of unit categories and tonotopic organization. Int. J. Neurosci. 4:147–66.
Møller AR (1974) Coding of sounds with rapidly varying spectrum in the cochlear nucleus. J. Acoust. Soc. Am. 55:631–40.
Shore SE, H El Kashlan and J Lu (2003) Effects of trigeminal ganglion stimulation on unit activity of ventral cochlear nucleus neurons. Neuroscience 119:1085–101.
Shore SE (2005) Multisensory integration in the dorsal cochlear nucleus: unit responses to acoustic and trigeminal ganglion stimulation. Eur. J. Neurosci. 21:3334–48.
Shulman A, J Tonndorf and B Goldstein (1985) Electrical tinnitus control. Acta Otolaryngol. 99:318–25.
Zhang J and Z Guan (2008) Modulatory effects of somatosensory electrical stimulation on neural activity of the dorsal cochlear nucleus of hamsters. J. Neurosci. Res. 86:1178–87.
Zhang J and Z Guan (2007) Pathways involved in somatosensory electrical modulation of dorsal cochlear nucleus activity. Brain Res. 1184:121–31.
Shore SE, S Koehler, M Oldakowski et al (2008) Dorsal cochlear nucleus responses to somatosensory stimulation are enhanced after noise-induced hearing loss. Eur. J. Neurosci. 27:155–68.
Szczepaniak WS and AR Møller (1993) Interaction between auditory and somatosensory systems: a study of evoked potentials in the inferior colliculus. Electroencephologr. Clin. Neurophysiol. 88:508–15.
Cacace AT, JP Cousins, SM Parnes et al (1999) Cutaneous-evoked tinnitus. II: review of neuroanatomical, physiological and functional imaging studies. Audiol. Neurotol. 4:258–68.
Cacace AT, JP Cousins, SM Parnes et al (1999) Cutaneous-evoked tinnitus. I: phenomenology, psychophysics and functional imaging. Audiol. Neurotol. 4:247–57.
Cacace AT, TJ Lovely, DJ McFarland et al (1994) Anomalous cross-modal plasticity following posterior fossa surgery: some speculations on gaze-evoked tinnitus. Hear. Res. 81:22–32.
Hotta T and K Kameda (1963) Interactions between somatic and visual or auditory responses in the thalamus of the cat. Exp. Neurol. 8:1–13.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Møller, A.R. (2011). Anatomy and Physiology of the Auditory System. In: Møller, A.R., Langguth, B., De Ridder, D., Kleinjung, T. (eds) Textbook of Tinnitus. Springer, New York, NY. https://doi.org/10.1007/978-1-60761-145-5_8
Download citation
DOI: https://doi.org/10.1007/978-1-60761-145-5_8
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-60761-144-8
Online ISBN: 978-1-60761-145-5
eBook Packages: MedicineMedicine (R0)