Dietary Components and Immune Function

Part of the series Nutrition and Health pp 421-468


Antiviral Activity of Phytochemicals: A Current Perspective

  • Rajesh NaithaniAffiliated withDrug Discovery Division, IIT Resrach institute Email author 
  • , Rajendra G. MehtaAffiliated withDrug Discovery Division, IIT Research InstituteCarcinogenesis Chemoprevention Division, IIT Research Institute
  • , Deepak ShuklaAffiliated withDepartment of Microbiology and Immunology, University of IllinoisDepartment of Ophthalmology and Visual Sciences, University of Illinois
  • , Susantha N. ChandersekeraAffiliated withDepartment of Chemistry, University of Illinois at Chicago
  • , Robert M. MoriartyAffiliated withDrug Discovery Division, IIT Research InstituteDepartment of Chemistry, University of Illinois

Key Points

A wide variety of active phytochemicals have been found to have therapeutic ­applications against genetically and functionally diverse viruses. The antiviral mechanism of these agents may be explained on the basis of their ­antioxidant activities, scavenging capacities, the inhibition of DNA, RNA synthesis, or the blocking of viral reproduction, etc. Numerous epidemiological and experimental studies have revealed that a large number of phytochemicals have promising antiviral activities. Especially in the last decade, a number of promising leads have been identified by a combination of in vitro and in vivo studies using diverse biological assays.

Key Words

Antiviral phytochemical infection replication flavonoids clinical ­trials mechanism