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Stem Cells and Cancer pp 231–246Cite as

Adult Prostate Epithelium Renewal, Stem Cells and Cancer

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Cancer is thought to develop from the neoplastic transformation of either stem cells that maintain the ability to self-renew or committed progenitor cells that undergo dedifferentiation and acquire stem cell characteristics. Thus, understanding prostate cell differentiation lineage during development as well as prostate epithelium renewal in adulthood represents a critical step in unraveling the mechanisms involved in prostate carcinogenesis. Recent advances in the field have started to clarify the hierarchical relationship between epithelial prostate cells. In addition, prostate cell populations with characteristics of stem cells have been identified. Further clarification of the processes that regulate normal prostate homeostasis is likely to shed additional light on the multistep process of prostate tumorigenesis.

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  1. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    Chiara Grisanzio & Sabina Signoretti

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  1. Chiara Grisanzio
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    Grisanzio, C., Signoretti, S. (2009). Adult Prostate Epithelium Renewal, Stem Cells and Cancer. In: Teicher, B., Bagley, R. (eds) Stem Cells and Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-60327-933-8_18

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