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Trends in Stem Cell Biology and Technology pp 123–136Cite as

Current Developments in Genetically Manipulated Mice

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Abstract

The use of genetically manipulated mice in medical research is one of the premier tools for the study of genetic diseases. I describe here our routine methods to produce these animals that have proven to be highly reliable as well as give exceptionally high rates of germline transmission with all strains of embryonic stem cells that we have used.

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Acknowledgements

I am indebted to my many collaborators with whom I have discussed ES cell culture. In my laboratory I am particularly indebted to my long-term technicians and valued colleagues Vane (Wayne) Damcevski and Helen Taylor without whom many of the mice would not have been so successfully generated.

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Authors and Affiliations

  1. Stem cell and Gene Targeting Laboratory, The Division of Molecular Bioscience, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia

    Klaus I. Matthaei

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Correspondence to Klaus I. Matthaei .

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    © 2009 Humana Press, a part of Springer Science+Business Media, LLC

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    Matthaei, K.I. (2009). Current Developments in Genetically Manipulated Mice. In: Baharvand, H. (eds) Trends in Stem Cell Biology and Technology. Humana Press. https://doi.org/10.1007/978-1-60327-905-5_8

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