Skip to main content
SpringerLink
Log in
Book cover

Guide to Signal Pathways in Immune Cells pp 11–23Cite as

Cell Membrane Receptors and Phospholipids

  • Chapter
  • First Online:

  • 994 Accesses

Abstract

Membrane phospholipids, in particular phosphatidylinositol (PtdIns), provide crucial phosphoinositides that activate enzymes like PI3 kinase, which drives the protein kinase B (Akt), cell survival and signal pathway. Also, calcium ions entering through membrane ion channels exert controls over vital enzymes.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Berridge HJ, Irvine RF. Inositol triphosphate, a novel second messenger in cellular signal transduction. Nature 1984;312:315–322

    Article  PubMed  CAS  Google Scholar 

  2. (a) Rebecchi MJ, Pentyla SN. Structure, function and control of phosphatidylinositol specific phospholipase C. Physiol Rev 2000;80:1291–1235; (b) Cockroft S, Thomas G. Inositol lipid specific phospholipase C isoenzymes and their regulation by receptors. Biochem J 1992;288:1–14

    PubMed  CAS  Google Scholar 

  3. Spitzer M, Cantrell DA. Protein kinase C and beyond. Nat Immunol 2004;5:785–790

    Article  Google Scholar 

  4. Rhee SG. Regulation of phosphoinositide specific phospholipase C. Annu Rev Biochem 2001;70:281–312

    Article  PubMed  CAS  Google Scholar 

  5. van Haesebroeck B, Leevers SJ, Ahmadi K et al Synthesis and function of 3-phosphatidylinositol phospholipids. Annu Rev Biochem 2001;70:535–602

    Article  CAS  Google Scholar 

  6. Review.. Protein kinase C isoenzymes:divergence in signal transduction. Biochem J 1993;291:329–343

    Google Scholar 

  7. Tan S-L, Parker PJ. Diverse roles of protein kinase C in immune cell signaling. Biochem J 2003;376:545–552

    Article  PubMed  CAS  Google Scholar 

  8. Nakashima S. Protein kinase C alpha: regulation and biological function. J Biochem 2002;132:669–675

    PubMed  CAS  Google Scholar 

  9. Larsen EC, Digennaro JA, Saito N et al Differential requirement for classic and novel protein kinase C isoforms in respiratory burst and phagocytosis. J Immunol 2000;165:2809–2017

    PubMed  CAS  Google Scholar 

  10. Von Essen M, Nielsen MW, Bonefeld CM et al Protein kinases C PKC α and PKC θ are the major PKC isotypes in T cell receptor down-regulation. J Immunol 2006;176:7502–7510

    PubMed  CAS  Google Scholar 

  11. Altman A, Villalba M. Protein kinase C θ. J Biochem 2002;132:841–846

    PubMed  CAS  Google Scholar 

  12. Liu Y, Graham C, Parraviceni V et al PKC-θ is expressed in mast cells and is involved in Fcε receptor I signaling. J Leukocyte Biol 2001;69:831–846

    PubMed  CAS  Google Scholar 

  13. Jackson DN, Foster DA. The enigmatic protein kinase Cδ:complex roles in cell proliferation and survival. FASEB J 2004;18:627–636

    Article  PubMed  CAS  Google Scholar 

  14. Majerus PW. Inositol phosphates. Annu Rev Biochem 1992;61:225–250

    Article  PubMed  CAS  Google Scholar 

  15. Santarius M, Lee CH, Anderson RA. Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools. Biochem J 2006;398:1–13

    Article  PubMed  CAS  Google Scholar 

  16. Forder J, Scriabne A, Rasmussen H. Plasma membrane calcium flux, protein kinase C activation and smooth muscle contraction. J Pharmacol Exp Ther 1985;235:267–273

    PubMed  CAS  Google Scholar 

  17. Di Paolo G, De Camilli P. Phosphoinsotides in cell regulation and membrane dynamics. Nature 2006;443:651–657

    Article  PubMed  CAS  Google Scholar 

  18. (a) Niggl V. Regulation of protein activities by phosphoinositide phosphates. Annu Rev Cell Dev Biol 2005;21:57–79; (b) Czech MP. Dynamics of phosphoinositides in membrane retrieval and insertion. Annu Rev Physiol 2003;65:791–815

    Article  Google Scholar 

  19. Sato M, Ueda Y, Takagi T, Umezawa Y. Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis. Nat Cell Biol 2003;5:1016–1020

    Article  PubMed  CAS  Google Scholar 

  20. Rameh LE, Arvidsson A-K, Carraway KL et al A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J Biol Chem 1997;272:22059–22066

    Article  PubMed  CAS  Google Scholar 

  21. Leslie NR, Downes CP. PTEN function. Biochem J 2004;382:1–11

    Article  PubMed  CAS  Google Scholar 

  22. Roth MG. Phosphoinositides in constitutive membrane Traffic. Physiol Rev 2004;84:699–730

    Article  PubMed  CAS  Google Scholar 

  23. Matteis MA, Godi A. PI-loting membrane traffic. Nat Cell Biol 2004;6:487–492

    Article  PubMed  Google Scholar 

  24. Shin HW, Nakayama K. Dual control of membrane targeting by PtdIns(4)P. Trends Biochem Sci 2004;29:513–515

    Article  PubMed  CAS  Google Scholar 

  25. Assano T, Yao Y, Zhu J et al The PI3kinase/Akt signaling pathway is activated due to aberrant PTEN expression in pancreatic cancer cells. Oncogene 2004;23:8571–8580

    Article  Google Scholar 

  26. He XC, Yin T, Grindley JC et al PTEN deficient intestinal stem cells initiate intestinal polyposis. Nature Genet 2007;39:189–198

    Article  PubMed  CAS  Google Scholar 

  27. Buckler JL, Walsh OT, Porrett PM et al T cell requirement for CD28 costimulation is due to negative regulation of T cell receptor signals by PTEN. J Immunol 2006;177:4262–4266

    PubMed  CAS  Google Scholar 

  28. Frauwirth KA, Thompson CB. Regulation of T lymphocyte metabolism. J Immunol 2004;172:4661–4665

    PubMed  CAS  Google Scholar 

  29. Richardson CJ, Schalm SS, Blenis J. PI-3kinase and TOR:PIKTORING cell growth. Semin Cell Dev Biol 2004;15:147–159

    Article  PubMed  CAS  Google Scholar 

  30. Wymann MP, Zvelebil M, Laffargue M. PI-3kinase signalling-which way to target? Trends Pharmacol Sci 2002;24:366–373

    Article  Google Scholar 

  31. (a) Deane JA, Fruman DA. Phosphoinositide 3-kinase:diverse roles in immune cell activation. Annu Rev Immunol 2004;22:563–598; (b) Icazar IA, Marques M, Kumar A et al. PI3-kinase γ participates in T cell receptor induced T cell activation. J Exp Med 2007;204:2977–2988

    Article  PubMed  CAS  Google Scholar 

  32. Ito K, Caramori G, Adcock IM. Therapeutic potential of PI3-kinase inhibitors in inflammatory respiratory disease. J Pharmacol Exp Ther 2007;321:1–8

    Article  PubMed  CAS  Google Scholar 

  33. Parry RV, Riley JL, Ward SG. Signalling to suit function: tailoring PI3kinase during T cell activation. Trend Immunol 2007;28:161–169

    Article  CAS  Google Scholar 

  34. Oak JS, Fruman DA. Role of phosphoinositide 3-kinase signaling in autoimmunity. Autoimmunity 2007;40(6):433–441

    Article  PubMed  CAS  Google Scholar 

  35. Procko E, McColl SR. Leukocytes on the move with PI3kinase and its downstream effectors. BioEssays 2005:27:153–163

    Article  PubMed  CAS  Google Scholar 

  36. Jones GE, Prigmore E, Calvez R et al Requirement for PI3kinase in macrophage migration to MCP-1 and CSF-1. Exp Cell Res 2003;290:120–131

    Article  PubMed  CAS  Google Scholar 

  37. Reif K, Okkenhaug K, Sasaki T et al Differentiation roles for PI3kinases p110γ and p110δ in lymphocyte chemotaxis and homing. J Immunol 2004;173:2236–2240

    PubMed  CAS  Google Scholar 

  38. Ortolano S, Huang IY, Han SB, Kehrl JH.Role of PI3-kinases, Brutons tyrosine kinase and Jun kinases in B lymphocyte chemotaxis and homing. Eur J Immunol 2006;36:1285–1295

    Article  PubMed  CAS  Google Scholar 

  39. Fruman DA, Rameh LE, Cantley LC. Phosphoinositide binding domains: embracing 3-phosphate. Cell 1999;97:817–820

    Article  PubMed  CAS  Google Scholar 

  40. Van Haesebroech B, Waterfield MD. Signaling by distinct classes of PI3kinases. Exp Cell Res 1999;253:239–254

    Article  Google Scholar 

  41. Coffer PJ, Jin J, Woodgett JR. Protein kinase B(Akt):a multifunctional mediator of PI3-kinase activation. Biochem J 1998;335:1–13

    PubMed  CAS  Google Scholar 

  42. Toker A, Cantley LC. Signalling through the lipid products of PI3kinase. Nature 1997;387:673–676

    Article  PubMed  CAS  Google Scholar 

  43. Wymann MP, Bjorklof K, Calvez R et al PI3kinase γ:a key modulator in inflammation and allergy. Biochem Soc Trans 2003;31:275–280

    Article  PubMed  CAS  Google Scholar 

  44. Stephens L, Ellson C, Hawkins P. Role of PI3kinase in leukocyte chemotaxis and phagocytosis. Curr Op Cell Biol 2002;14:203–213

    Article  PubMed  CAS  Google Scholar 

  45. Sadhu C, Masinivsky B, Dick K et al Essential role of PI3kinaseδ in neutrophil directional movement. J Immunol 2003;170:2647–2654

    PubMed  CAS  Google Scholar 

  46. Ward SG, Finan P. Isoform-specific PI3kinase inhibitors as therapeutic agents. Curr Opin Pharmacol 2003;3:426–434

    Article  PubMed  CAS  Google Scholar 

  47. Klein JB, Ranc MJ, Scherzer JA et al GM-CSF delays neutrophil apoptosis through PI3kinase and ERK pathway. J Immunol 2000;163:4286–4291

    Google Scholar 

  48. Yum H-K, Arcaroli J, Kupfner J et al Involvement of PI3kinases in neutrophil activation and development of acute lung injury. J Immunol 2001;167:6601–6608

    PubMed  CAS  Google Scholar 

  49. Hirsch E, Katanaev V, Garlanda C, Azzolino O et al Central role for G-protein coupled PI 3kinase in inflammation. Science 2000;287:1049–1053

    Article  PubMed  CAS  Google Scholar 

  50. Tanaka H, Fujita N, Tsuruo T. 3Phosphoinositide-dependent protein kinase-1 mediated IkBkinase β phospohorylation activates NFkB signaling. J Biol Chem 2005;280:40965–40973

    Article  PubMed  CAS  Google Scholar 

  51. Ward SG, June CH, Olive D. PI 3-kinase: a pivotal pathway in T cell activation. Immunol Today 1996;17:187–198

    Article  PubMed  CAS  Google Scholar 

  52. Eder AM, Dominiquez L, Frank TF et al PI 3-kinase regulation of a T cell receptor mediated interleukin 2 gene expression in normal T cells. J Biol Chem 1998; 273: 28025–28031

    Article  PubMed  CAS  Google Scholar 

  53. Hazeki K, Nogorikawa K, Hazeki O. Role of phosphoinositide 3-kinase in innate immunity. Biol Pharm Bull 2007;30(9):1617–1623

    Article  PubMed  CAS  Google Scholar 

  54. Stambolic V, Woodgett JR. Functional distinction of protein kinase B/Akt isoforms defined by their influence on cell migration. Trend Cell Biol 2006;16(9):461–466

    Article  CAS  Google Scholar 

  55. Zhang SL, Yu Y, Roos J et al STIM1 is a calcium sensor that activates CRAC channels. Nature 2005;437:902–905

    Article  PubMed  CAS  Google Scholar 

  56. Gallo EM, Cante-Barrett K, Crabtree GR. Lymphocyte calcium signaling from membrane to nucleus. Nature Immunol 2006;7:25–31

    Article  CAS  Google Scholar 

  57. Schlossman J, Feil R, Hofmann T. Signaling through nitric oxide and cGMP dependent protein kinases. Ann Med 2003;35(1):21–27

    Article  Google Scholar 

  58. Rakhelin SV, Olson PA, Nishi A et al A network of control mediated by regulator of calmodulin dependent signaling. Science 2004;306:698–701

    Article  Google Scholar 

  59. Berridge MJ. AM and FM of calcium signalling. Nature 1997;386:759–760

    Article  PubMed  CAS  Google Scholar 

  60. Feske S. Calcium signalling in lymphocyte activation. Nat Rev Immunol 07;7:690–702

    Article  Google Scholar 

  61. Yule DI. Subtype specific regulation of inositol 1,4,5 triphosphate receptors. Controlling agents in time and space. J Gen Physiol 2001;117:431–434

    Article  PubMed  CAS  Google Scholar 

  62. Taylor CW. Store operated Ca2+ entry: a STIMulating stOrai. Trends Biochem Sci 2006;31:597–601

    Article  PubMed  CAS  Google Scholar 

  63. Panyi G, Vannosi G, Bodnor A et al Looking through ion channels: recharged events in T cell signaling. Trends Immunol 2004;25:565–569

    Article  PubMed  CAS  Google Scholar 

  64. Ayub K, Hallett MB. The mitochondrial ADPR link between Ca2+ store release and Ca2+ influx channel opening in immune cells. FASEB J 2004;18:1335–1338

    Article  PubMed  CAS  Google Scholar 

  65. Di Fiore PP. Life on Mars, cellular speaking. Nature 2003;424:624–625

    Article  PubMed  CAS  Google Scholar 

  66. Savignac M, Gomes B, Gallard A et al Dihydropyridine receptors are selective markers of Th-2 cells. J Immunol 2004;172:5206–5212

    PubMed  CAS  Google Scholar 

  67. Gomes B, Savignac M, Cabral MD et al Cyclic GMP/protein kinase G pathway controls dihydropyridine channels. J Biol Chem 2006;281:12421–12427

    Article  PubMed  CAS  Google Scholar 

  68. Zhu P, Liu X, Labelle E, Freedman B. Mechanisms of hypotonicity induced calcium signaling. J Immunol 2005;175:4981–4989

    PubMed  CAS  Google Scholar 

  69. Lefkowitz RJ, Whalen EJ. β-Arrestins. Curr Opin Cell Biol 2004;16:162–168

    Article  PubMed  CAS  Google Scholar 

  70. Wojcikiewicz R, Tobin AB, Nahorski SR. Desensitization of cell signalling mediated by phosphoinositidase C. Trends Pharmacol Sci 1993;14:279–228

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Royal Society of Medicine, London, W1G 0AE, United Kingdom

    E. Nigel Wardle

Authors
  1. E. Nigel Wardle
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. Nigel Wardle .

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Wardle, E.N. (2009). Cell Membrane Receptors and Phospholipids. In: Guide to Signal Pathways in Immune Cells. Humana Press. https://doi.org/10.1007/978-1-60327-538-5_2

Download citation

Publish with us

Policies and ethics

Search

Navigation