Abstract
Seizures are a nonspecific neurological manifestation of cerebral dysfunction and not indicative of any particular disease processes or pathology. As such, the evaluation and treatment of seizures in transplant patients generally follow the same clinical approach as for other patients. A seizure in a transplant patient is commonly unanticipated and entirely unexplained. The effects can be substantial with aspiration, loss of vascular catheters, and tissue trauma. Patients undergoing organ transplantation are at risk of seizures for multiple reasons, and while much of the neurological and transplantation literature reports on the incidence of seizures according to the particular organ transplanted, there are many similarities (e.g., Immunosuppression drugs) and we will try to concentrate on organ transplantation as a whole.
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Wszolek Z, Steg RE, Wijdicks EF (1999) Seizures. In: Wijdicks EF (ed) Neurologic complications in organ transplant recipients. Butterworth and Heinemann, Boston, pp 107–125
Wszolek ZK, Steg RE (1997) Seizures after orthotopic liver transplantation. Seizure 6:31–39
Martinez AJ, Estol C, AA F (1988) Neurologic complications of liver transplantation. Neurol Clin 6:327
Adams DH, Ponsford S, Gunson B et al (1987) Neurological complications after liver transplantation. Lancet 1:949–951
Wijdicks EF, Plevak DJ, Wiesner RH, Steers JL (1996) Causes and outcome of seizures in liver transplant recipients. Neurology 47:1523–1525
Wijdicks EF, Wiesner RH, Dahlke L, Krom R (1994) FK506-induced neurotoxicity in liver transplantation. Ann Neurol 35:498
Wijdicks EF, Wiesner RH, Krom R (1995) Neurotoxicity in liver transplant recipients with cyclosporine immunosuppresion. Neurology 45:1962
Sevmis S, Karakayali H, Emiroglu R, Akkoc H, Haberal M (2007) Tacrolimus-related seizure in the early postoperative period after liver transplantation. Transplant Proc 39(4):1211–1213
Patchell RA, White CL III, Clark AW, Beschorner WE, Santos GW (1985) Neurologic complications of bone marrow transplantation. Neurology 35:300–306
Snider S, Bashir R, Bierman P (1994) Neurologic complications after high-dose chemotherapy and autologous bone marrow transplantation for Hodgkin’s disease. Neurology 44:681
Antonini G, Ceschin V, Morino S et al (1998) Early neurologic complications following allogeneic bone marrow transplant for leukemia: A prospective study. Neurology 50:1441–1445
Wszolek Z, Steg R, Armitage J Complex partial status epilepticus after bone marrow transplantation for non-Hodgkin’s lymphoma. Bone Marrow Transplant 19:637–638
Gaggero R, Haupt R, Paola Fondelli M, De Vescovi R, Marino A, Lanino E, Dallorso S, Faraci M (2006) Intractable epilepsy secondary to cyclosporine toxicity in children undergoing allogeneic hematopoietic bone marrow transplantation. J Child Neurol 21(10):861–866
Grigg MM, Costanzo-Nordin MR, Celesia GG et al (1988) The etiology of seizures after cardiac transplantation. Transplant Proc 20(Suppl 3):937
Malheiros S, Almeida D, Massaro A et al (2002) Neurologic complications after heart transplantation. Arq Neuropsiquiatr 60:192–197
Mayer TO, Biller J, O’Donnell J, Meschia JF, Sokol DK (2002) Contrasting the neurologic complications of cardiac transplantation in adults and children. J Child Neurol 17:195–199
LM AAQ, Postlethwaite RJ, Webb NJ (1999) Seizures following renal transplantation in childhood. Pediatr Nephrol 13:275–277
Kahan BD, Flechner SM, Lorber MI, Golden D, Conley S, Van Buren CT (1987) Complications of cyclosporine-prednisone immunosuppression in 402 renal allograft recipients exclusively followed at a single center for from one to five years. Transplantation 43:197–204
Gross M, Sweny P, Pearson R, Kennedy J, Fernando O, Moorhead J (1982) Rejection encephalopathy. An acute neurological syndrome complicating renal transplantation. J Neurol Sci 56:23–34
Vaughn BV, Ali, II, Olivier KN et al (1996) Seizures in lung transplant recipients. Epilepsia 37:1175–1179
Wong M, Mallory GB Jr, Goldstein J, Goyal M, Yamada KA (1999) Neurologic complications of pediatric lung transplantation. Neurology 53:1542–1549
Kiok MC (1988) Neurologic complications of pancreas transplants. Neurol Clin 6:367–376
Alroughani R, Javidan M, Qasem A, Alotaibi N (2009) Non-convulsive status epilepticus; the rate of occurrence in a general hospital. Seizure 18(1):38–42
Wijdicks EF (1999) Neuologic Manesfestations of Immunosuppressive Agents. In: Wijdicks EF (ed) Neurologic complications in organ transplant recipients. Butterworth and Heinemann, Boston, pp 127–140
Gilmore RL (1988) Seizures and antiepileptic drug use in transplant patients. Neurol Clin 6:279–296
Kahan BD (1989) Cyclosporin. N Eng J Med 312:1725
Rubin AM, Kang H (1987) Cerebral blindness and encephalopathy with cyclosporin A toxicity. Neurology 37:1072
Wilson SE, de Groen PC, Aksamit AJ, Wiesner RH, Garrity JA, RA K (1988) Cyclosporin A-induced reversible cortical blindness. J Clin Neuroophthalmol 8:215–220
Truwit CL, Denaro CP, Lake JR, Demarco T (1991) MR imaging of reversible cyclosporin A-induced neurotoxicity. AJNR 12:651
Reece DE, Frei-Lahr DA, Shepard JD et al (1991) Neurologic complications in allogenic bone marrow transplant patients receiving cyclosporin. Bone Marrow Transplant 8:393
Thompson CB, June CH, Sullivan KM, Thomas ED (1984) Association between cyclosporin neurotoxicity and hypomagnesaemia. Lancet 2:1116
de Groen PC, Aksamit AJ, Rakela J et al (1987) Central nervous system toxicity after liver transplantation. The role of cyclosporin and cholesterol. N Eng J Med 317:861
Hauben M (1996) Cyclosporine neurotoxicity. Pharmacotherapy 16:576
Kelly PA, Burckart GJ, Venkataramanan R (1995) Tacrolimus: A new immunosuppressive agent. Am J Health Syst Pharm 53:1521
Shutter LA, Green JP, NJ Newman et al (1993) Cortical blindness and white matter lesions in a patient FK506 after liver transplantation. Neurology 43:2417
Parlevliet KJ, Bemelman FJ, Yong SL et al (1995) Toxicity of OKT3 increases with dosage: A controlled study in renal transplant recipients. Transplant Int 8:141
Seifeldin RA, Lawrence KR, Rahamtulla AF, AP M (1997) Generalized seizures associated with the use of muromonab-CD3 in two patients after kidney transplantation. Ann Pharmacother 31:586
Dukar O, Barr CC (1993) Visual loss complicating OKT3 monoclonal antibody therapy. Am J Opthalmol 115:781
De La Camara R, Tomas JF, Figuera A et al (1998) High dose busulfan and seizures. Bone Marrow Transplant 7:363
Jagannath S, Armitage JO, Dicke KA et al (1989) Prognostic factors for response and survival after high-dose cyclophosphamide, carmustine, and etoposide with autologous bone marrow transplantation for relapsed Hodgkins’s disease. J Clin Oncol 7:179
Seifeldin RA (1995) Drug interactions in transplantation. Clin Ther 17:1043
Lowenstein DH, Alldredge BK (1998) Current concepts: status epilepticus. N Eng J Med 338:970–976
Sinha S, Naritoku DK (2000) Intravenous valproate is well tolerated in unstable patients with status epilepticus. Neurology 55:722–724
Manno EM (2003) New management strategies in the treatment of status epilepticus. Mayo Clin Proc 78:508–518
Kreuz W, Linde R, Funk M et al (1992) Valproate therapy induces von Willebrand disease type I. Epilepsia 33:178–184
Glass GA, Stankiewicz J, Mithoefer A, Freeman R, Bergethon PR (2005) Levetiracetam for seizures after liver transplantation. Neurology 64(6):1084–1085
Speeg KV, Halff GA, Schenker S (1995) Metabolsim of drugs before and after liver transplantation. In: Maddrey WC, MF S (eds) Transplantation of the liver, Appleton & Lange, Norwalk, CT, pp 427
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Zakaria, T., Wijdicks, E.F.M., Worrell, G.A. (2010). Seizures in Organ Transplant Recipients. In: Varelas, P. (eds) Seizures in Critical Care. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-532-3_8
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DOI: https://doi.org/10.1007/978-1-60327-532-3_8
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