Skip to main content
SpringerLink
Log in

Liver Resection for Hepatocellular Carcinoma

  • Chapter
  • First Online:
Hepatocellular Carcinoma:

  • 1252 Accesses

Abstract

The natural history of untreated HCC varies depending on the stage at presentation and the degree of underlying liver disease. However, even in patients with early stages, the prognosis is poor if the disease is left untreated [1, 2]. As primary medical therapy has failed to significantly improve survival, surgical resection and orthotopic liver transplantation (OLT) represent the only treatment options offering a prospect for cure with 5-year survival rates of up to 50% [3–5] and 70% [6, 7], respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Nagasue N, Yukaya H, Hamada T, Hirose S, Kanashima R, Inokuchi K (1984) The natural history of hepatocellular carcinoma. A study of 100 untreated cases. Cancer 54:1461–1465

    Article  CAS  PubMed  Google Scholar 

  2. Barbara L, Benzi G, Gaiani S et al (1992) Natural history of small untreated hepatocellular carcinoma in cirrhosis: a multivariate analysis of prognostic factors of tumor growth rate and patient survival. Hepatology 16:132–137

    Article  CAS  PubMed  Google Scholar 

  3. Shuto T, Hirohashi K, Kubo S et al (1998) Changes and results of surgical strategies for hepatocellular carcinoma: results of a 15-year study on 452 consecutive patients. Surg Today 28:1124–1129

    Article  CAS  PubMed  Google Scholar 

  4. Zhou XD, Tang ZY, Yang BH et al (2001) Experience of 1000 patients who underwent hepatectomy for small hepatocellular carcinoma. Cancer 91:1479–1486

    Article  CAS  PubMed  Google Scholar 

  5. Takenaka K, Kawahara N, Yamamoto K et al (1996) Results of 280 liver resections for hepatocellular carcinoma. Arch Surg 131:71–76

    CAS  PubMed  Google Scholar 

  6. Mazzaferro V, Regalia E, Doci R et al (1996) Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 334:693–699

    Article  CAS  PubMed  Google Scholar 

  7. Llovet JM, Bruix J, Fuster J et al (1998) Liver transplantation for small hepatocellular carcinoma: the tumor-node-metastasis classification does not have prognostic power. Hepatology 27:1572–1577

    Article  CAS  PubMed  Google Scholar 

  8. Cance WG, Stewart AK, Menck HR (2000) The National Cancer Data Base Report on treatment patterns for hepatocellular carcinomas: improved survival of surgically resected patients, 1985–1996. Cancer 88:912–920

    Article  CAS  PubMed  Google Scholar 

  9. Fong Y, Sun RL, Jarnagin W, Blumgart LH (1999) An analysis of 412 cases of hepatocellular carcinoma at a Western center. Ann Surg 229:790–799

    Article  CAS  PubMed  Google Scholar 

  10. Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O (2000) Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg 191:38–46

    Article  CAS  PubMed  Google Scholar 

  11. Wei AC, Tung-Ping Poon R, Fan ST, Wong J (2003) Risk factors for perioperative morbidity and mortality after extended hepatectomy for hepatocellular carcinoma. Br J Surg 90:33–41

    Article  CAS  PubMed  Google Scholar 

  12. Pawlik TM, Poon RT, Abdalla EK et al (2005) Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma. Arch Surg 140:450–457

    Article  PubMed  Google Scholar 

  13. Kosuge T, Makuuchi M, Takayama T, Yamamoto J, Shimada K, Yamasaki S (1993) Long-term results after resection of hepatocellular carcinoma: experience of 480 cases. Hepatogastroenterology 40:328–332

    CAS  PubMed  Google Scholar 

  14. Ng KK, Vauthey JN, Pawlik TM et al (2005) Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database. Ann Surg Oncol 12:364–373

    Article  PubMed  Google Scholar 

  15. Liu CL, Fan ST, Lo CM, Ng IO, Poon RT, Wong J (2003) Hepatic resection for bilobar hepatocellular carcinoma: is it justified? Arch Surg 138:100–104

    Article  PubMed  Google Scholar 

  16. Pawlik TM, Poon RT, Abdalla EK et al (2005) Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: results of a multicenter study. Surgery 137:403–410

    Article  PubMed  Google Scholar 

  17. Minagawa M, Makuuchi M, Takayama T, Ohtomo K (2001) Selection criteria for hepatectomy in patients with hepatocellular carcinoma and portal vein tumor thrombus. Ann Surg 233:379–384

    Article  CAS  PubMed  Google Scholar 

  18. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R (1973) Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60:646–649

    Article  CAS  PubMed  Google Scholar 

  19. Mansour A, Watson W, Shayani V, Pickleman J (1997) Abdominal operations in patients with cirrhosis: still a major surgical challenge. Surgery 122:730–735

    Article  CAS  PubMed  Google Scholar 

  20. Teh SH, Christein J, Donohue J et al (2005) Hepatic resection of hepatocellular carcinoma in patients with cirrhosis: model of end-stage liver disease (MELD) score predicts perioperative mortality. J Gastrointest Surg 9:1207–1215

    Article  PubMed  Google Scholar 

  21. Belghiti J, Regimbeau JM, Durand F et al (2002) Resection of hepatocellular carcinoma: a European experience on 328 cases. Hepatogastroenterology 49:41–46

    CAS  PubMed  Google Scholar 

  22. Makuuchi M, Kosuge T, Takayama T, et al (1993) Surgery for small liver cancers. Semin Surg Oncol 9:298–304

    Article  CAS  PubMed  Google Scholar 

  23. Bruix J, Castells A, Bosch J et al (1996) Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure. Gastroenterology 111:1018–1122

    Article  CAS  PubMed  Google Scholar 

  24. Eguchi H, Umeshita K, Sakon M et al (2000) Presence of active hepatitis associated with liver cirrhosis is a risk factor for mortality caused by posthepatectomy liver failure. Dig Dis Sci 45:1383–1388

    Article  CAS  PubMed  Google Scholar 

  25. Haber MM, West AB, Haber AD, Reuben A (1995) Relationship of aminotransferases to liver histological status in chronic hepatitis C. Am J Gastroenterol 90:1250–1257

    CAS  Google Scholar 

  26. Healey CJ, Chapman RW, Fleming KA (1995) Liver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases. Gut 37:274–278

    Article  CAS  PubMed  Google Scholar 

  27. Poon RT, Fan ST, Lo CM, Liu CL, Ng IO, Wong J (2000) Long-term prognosis after resection of hepatocellular carcinoma associated with hepatitis B-related cirrhosis. J Clin Oncol 18:1094–1101

    CAS  PubMed  Google Scholar 

  28. Noun R, Jagot P, Farges O, Sauvanet A, Belghiti J (1997) High preoperative serum alanine transferase levels: effect on the risk of liver resection in Child grade A cirrhotic patients. World J Surg 21:390–394

    Article  CAS  PubMed  Google Scholar 

  29. Torzilli G, Makuuchi M, Inoue K et al (1999) No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our approach. Arch Surg 134:984–992

    Article  CAS  PubMed  Google Scholar 

  30. Vauthey JN, Abdalla EK, Doherty DA et al (2002) Body surface area and body weight predict total liver volume in Western adults. Liver Transpl 8:233–240

    Article  PubMed  Google Scholar 

  31. Johnson TN, Tucker GT, Tanner MS, Rostami-Hodjegan A (2005) Changes in liver volume from birth to adulthood: A meta-analysis. Liver Transpl 11:1481–1493

    Article  PubMed  Google Scholar 

  32. Shirabe K, Shimada M, Gion T et al (1999) Postoperative liver failure after major hepatic resection for hepatocellular carcinoma in the modern era with special reference to remnant liver volume. J Am Coll Surg 188:304–309

    Article  CAS  PubMed  Google Scholar 

  33. Ribero D, Abdalla EK, Madoff DC, Donadon M, Loyer EM, Vauthey JN (2007) Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome. Br J Surg 94:1386–1394

    Article  CAS  PubMed  Google Scholar 

  34. Zorzi D, Laurent A, Pawlik TM, Lauwers GY, Vauthey JN, Abdalla EK (2007) Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surg 94:274–286

    Article  PubMed  Google Scholar 

  35. Palavecino M, Chun YS, Madoff DC et al (2009) Major hepatic resection for hepatocellular carcinoma with or without portal vein embolization: Perioperative outcome and survival. Surgery 145:399–405

    Article  PubMed  Google Scholar 

  36. Kokudo N, Tada K, Seki M et al (2001) Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization. Hepatology 34:67–72

    Article  Google Scholar 

  37. Nagino M, Nimura Y, Kamiya J, Kanai M, Hayakawa N, Yamamoto H (1998) Immediate increase in arterial blood flow in embolized hepatic segments after portal vein embolization: CT demonstration. AJR Am J Roentgenol 171:1037–1039

    CAS  PubMed  Google Scholar 

  38. Ogata S, Belghiti J, Farges O, Varma D, Sibert A, Vilgrain V (2006) Sequential arterial and portal vein embolizations before right hepatectomy in patients with cirrhosis and hepatocellular carcinoma. Br J Surg 93:1091–1098

    Article  CAS  PubMed  Google Scholar 

  39. Aoki T, Imamura H, Hasegawa K et al (2004) Sequential preoperative arterial and portal venous embolizations in patients with hepatocellular carcinoma. Arch Surg 2004;139(7):766–774

    Google Scholar 

  40. Llovet JM, Ricci S, Mazzaferro V et al (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359:378–390

    Article  CAS  PubMed  Google Scholar 

  41. Leung TW, Patt YZ, Lau WY et al (1999) Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma. Clin Cancer Res 5:1676–1681

    CAS  PubMed  Google Scholar 

  42. Zorzi D, Abdalla EK, Pawlik TM, Brown TD, Vauthey JN (2006) Subtotal hepatectomy following neoadjuvant chemotherapy for a previously unresectable hepatocellular carcinoma. J Hepatobiliary Pancreat Surg 13:347–350

    Article  PubMed  Google Scholar 

  43. Lau WY, Leung TW, Lai BS et al (2001) Preoperative systemic chemoimmunotherapy and sequential resection for unresectable hepatocellular carcinoma. Ann Surg 233:236–241

    Article  CAS  PubMed  Google Scholar 

  44. Chang SB, Palavecino M, Wray CJ, Kishi Y, Pisters PW, Vauthey JN (2010) Modified Makuuchi incision for foregut procedures. Arch Surg 145:281–284

    Google Scholar 

  45. Kokudo N, Bandai Y, Imanishi H et al (1996) Management of new hepatic nodules detected by intraoperative ultrasonography during hepatic resection for hepatocellular carcinoma. Surgery 119:634–640

    Article  CAS  PubMed  Google Scholar 

  46. Takigawa Y, Sugawara Y, Yamamoto J et al (2001) New lesions detected by intraoperative ultrasound during liver resection for hepatocellular carcinoma. Ultrasound Med Biol 27:151–156

    Article  CAS  PubMed  Google Scholar 

  47. Torzilli G, Makuuchi M (2003) Intraoperative ultrasonography in liver cancer. Surg Oncol Clin N Am 12:91–103

    Article  PubMed  Google Scholar 

  48. Lau WY, Leung KL, Lee TW, Li AK (1993) Ultrasonography during liver resection for hepatocellular carcinoma. Br J Surg 80:493–494

    Article  CAS  PubMed  Google Scholar 

  49. Hasegawa K, Kokudo N, Imamura H, et al (2005) Prognostic impact of anatomic resection for hepatocellular carcinoma. Ann Surg 242:252–259

    Article  PubMed  Google Scholar 

  50. Regimbeau JM, Kianmanesh R, Farges O, Dondero F, Sauvanet A, Belghiti J (2002) Extent of liver resection influences the outcome in patients with cirrhosis and small hepatocellular carcinoma. Surgery 131:311–317

    Article  PubMed  Google Scholar 

  51. Poon RT, Fan ST, Ng IO, Wong J (2000) Significance of resection margin in hepatectomy for hepatocellular carcinoma: a critical reappraisal. Ann Surg 231:544–551

    Article  CAS  PubMed  Google Scholar 

  52. Jwo SC, Chiu JH, Chau GY, Loong CC, Lui WY (1992) Risk factors linked to tumor recurrence of human hepatocellular carcinoma after hepatic resection. Hepatology 16:1367–1371

    Article  CAS  PubMed  Google Scholar 

  53. Yamamoto J, Kosuge T, Takayama T et al (1996) Recurrence of hepatocellular carcinoma after surgery. Br J Surg 83:1219–1222

    Article  CAS  PubMed  Google Scholar 

  54. Cha CH, Ruo L, Fong Y et al (2003) Resection of hepatocellular carcinoma in patients otherwise eligible for transplantation. Ann Surg 238: 315–321

    PubMed  Google Scholar 

  55. Ozawa K (1990) Hepatic function and liver resection. J Gastroenterol Hepatol 5:296–309

    Article  CAS  PubMed  Google Scholar 

  56. Liu CL, Fan ST, Lo CM, Tung-Ping Poon R, Wong J (2000) Anterior approach for major right hepatic resection for large hepatocellular carcinoma. Ann Surg 232:25–31

    Article  CAS  PubMed  Google Scholar 

  57. Liu CL, Fan ST, Cheung ST, Lo CM, Ng IO, Wong J (2006) Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomized controlled study. Ann Surg 244:194–203

    Article  PubMed  Google Scholar 

  58. Belghiti J, Guevara OA, Noun R, Saldinger PF, Kianmanesh R (2001) Liver hanging maneuver: a safe approach to right hepatectomy without liver mobilization. J Am Coll Surg 193:109–111

    Article  CAS  PubMed  Google Scholar 

  59. Man K, Fan ST, Ng IO, Lo CM, Liu CL, Wong J (1997) Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized study. Ann Surg 226:04–11

    Article  Google Scholar 

  60. Belghiti J, Noun R, Malafosse R et al (1999) Continuous versus intermittent portal triad clamping for liver resection: a controlled study. Ann Surg 229:369–375

    Article  CAS  PubMed  Google Scholar 

  61. Belghiti J, Noun R, Zante E, Ballet T, Sauvanet A (1996) Portal triad clamping or hepatic vascular exclusion for major liver resection. A controlled study. Ann Surg 224:155–161

    Article  CAS  PubMed  Google Scholar 

  62. Torzilli G, Makuuchi M, Midorikawa Y et al (2001) Liver resection without total vascular exclusion: hazardous or beneficial? An analysis of our experience. Ann Surg 233:167–175

    Article  CAS  PubMed  Google Scholar 

  63. Johnson M, Mannar R, Wu AV (1998) Correlation between blood loss and inferior vena caval pressure during liver resection. Br J Surg 85:188–190

    Article  CAS  PubMed  Google Scholar 

  64. Rees M, Plant G, Wells J, Bygrave S (1996) One hundred and fifty hepatic resections: evolution of technique towards bloodless surgery. Br J Surg 83:1526–1529

    Article  CAS  PubMed  Google Scholar 

  65. Cunningham JD, Fong Y, Shriver C, Melendez J, Marx WL, Blumgart LH (1994) One hundred consecutive hepatic resections. Blood loss, transfusion, and operative technique. Arch Surg 129:1050–1056

    CAS  PubMed  Google Scholar 

  66. Aloia TA, Zorzi D, Abdalla EK, Vauthey JN (2005) Two-surgeon technique for hepatic parenchymal transection of the noncirrhotic liver using saline-linked cautery and ultrasonic dissection. Ann Surg 242:172–177

    Article  PubMed  Google Scholar 

  67. Takatsuki M, Eguchi S, Yamanouchi K et al (2009) Two-surgeon technique using saline-linked electric cautery and ultrasonic surgical aspirator in living donor hepatectomy: its safety and efficacy. Am J Surg 197, e25–e27

    Google Scholar 

  68. El Moghazy WM, Hedaya MS, Kaido T, Egawa H, Uemoto S, Takada Y (2009) Two different methods for donor hepatic transection: cavitron ultrasonic surgical aspirator with bipolar cautery versus cavitron ultrasonic surgical aspirator with radiofrequency coagulator-A randomized controlled trial. Liver Transpl 15:102–105

    Article  PubMed  Google Scholar 

  69. Katz SC, Shia J, Liau KH et al (2009) Operative blood loss independently predicts recurrence and survival after resection of hepatocellular carcinoma. Ann Surg 249:617–623

    Article  PubMed  Google Scholar 

  70. Petrowsky H, Demartines N, Rousson V, Clavien PA (2004) Evidence-based value of prophylactic drainage in gastrointestinal surgery: a systematic review and meta-analyses. Ann Surg 240:1074–1084

    Article  PubMed  Google Scholar 

  71. Liu CL, Fan ST, Lo CM et al (2004) Abdominal drainage after hepatic resection is contraindicated in patients with chronic liver diseases. Ann Surg. 239:194–201

    Article  PubMed  Google Scholar 

  72. Foster JH, Berman MM (1977) Solid Liver Tumors.W. B. Saunders, Philadelphia

    Google Scholar 

  73. Jaeck D, Bachellier P, Oussoultzoglou E, Weber JC, Wolf P (2004) Surg.ical resection of hepatocellular carcinoma. Post-operative outcome and long-term results in Europe: an overview. Liver Transpl 10(2 Suppl 1):S58–S63

    Google Scholar 

  74. Makuuchi M, Takayama T, Gunven P, Kosuge T, Yamazaki S, Hasegawa H (1989) Restrictive versus liberal blood transfusion policy for hepatectomies in cirrhotic patients. World J Surg. 13:644–648

    Article  CAS  PubMed  Google Scholar 

  75. Shimada M, Takenaka K, Fujiwara Y et al (1998) Risk factors linked to postoperative morbidity in patients with hepatocellular carcinoma. Br J Surg. 85:195–198

    Article  CAS  PubMed  Google Scholar 

  76. Bismuth H, Majno P, Adam R (1999) Hepatocellular carcinoma: from ethanol injection to liver transplantation. Acta Gastroenterologica Belgica 62:330–341

    CAS  Google Scholar 

  77. Capussotti L, Borgonovo G, Bouzari H, Smadja C, Grange D, Franco D (1994) Results of major hepatectomy for large primary liver cancer in patients with cirrhosis. Br J Surg. 81:427–431

    Article  CAS  PubMed  Google Scholar 

  78. Belghiti J, Panis Y, Farges O, Benhamou JP, Fekete F (1991) Intrahepatic recurrence after resection of hepatocellular carcinoma complicating cirrhosis. Ann Surg. 214:114–117

    Article  CAS  PubMed  Google Scholar 

  79. Nagasue N, Kohno H, Chang YC et al (1993) Liver resection for hepatocellular carcinoma. Results of 229 consecutive patients during 11 years. Ann Surg. 217:375–384

    Article  CAS  PubMed  Google Scholar 

  80. Suenaga M, Sugiura H, Kokuba Y, Uehara S, Kurumiya T (1994) Repeated hepatic resection for recurrent hepatocellular carcinoma in eighteen cases. Surg.ery 115:452–457

    CAS  Google Scholar 

  81. Kakazu T, Makuuchi M, Kawasaki S et al (1993) Repeat hepatic resection for recurrent hepatocellular carcinoma. Hepatogastroenterology 40:337–341

    CAS  PubMed  Google Scholar 

  82. Matsuda Y, Ito T, Oguchi Y, Nakajima K, Izukura T (1993) Rationale of surg.ical management for recurrent hepatocellular carcinoma. Ann Surg. 217:28–34

    Article  CAS  PubMed  Google Scholar 

  83. Shimada M, Takenaka K, Taguchi K et al (1998) Prognostic factors after repeat hepatectomy for recurrent hepatocellular carcinoma. Ann Surg. 227:80–85

    Article  CAS  PubMed  Google Scholar 

  84. Arii S, Monden K, Niwano M et al (1998) Results of surg.ical treatment for recurrent hepatocellular carcinoma; comparison of outcome among patients with multicentric carcinogenesis, intrahepatic metastasis, and extrahepatic recurrence. J Hepatobiliary Pancreat Surg. 5:86–92

    Article  CAS  PubMed  Google Scholar 

  85. Minagawa M, Makuuchi M, Takayama T, Kokudo N (2003) Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma. Ann Surg. 238:703–710

    Article  PubMed  Google Scholar 

  86. Shimada K, Sakamoto Y, Esaki M et al (2007) Analysis of prognostic factors affecting survival after initial recurrence and treatment efficacy for recurrence in patients undergoing potentially curative hepatectomy for hepatocellular carcinoma. Ann Surg. Oncol 14:2337–2347

    Article  PubMed  Google Scholar 

  87. The Liver Cancer Study Group of Japan (1994) Predictive factors for long-term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. Cancer 74:2772–2780

    Article  Google Scholar 

  88. Bismuth H, Chiche L, Adam R, Castaing D, Diamond T, Dennison A (1993) Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg. 218:145–151

    Article  CAS  PubMed  Google Scholar 

  89. Jonas S, Herrmann M, Rayes N et al (2001) Survival after liver transplantation for hepatocellular carcinoma in cirrhosis according to the underlying liver disease. Transplant Proc 33:3444–3445

    Article  CAS  PubMed  Google Scholar 

  90. Poon RT, Fan ST, Lo CM, Liu CL, Wong J (2002) Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: implications for a strategy of salvage transplantation. Ann Surg. 235:373–382

    Article  PubMed  Google Scholar 

  91. Fisher RA, Maroney TP, Fulcher AS et al (2002) Hepatocellular carcinoma: strategy for optimizing surg.ical resection, transplantation and palliation. Clin Transplant 16 (Suppl 7):52–58

    Article  PubMed  Google Scholar 

  92. Majno PE, Sarasin FP, Mentha G, Hadengue A (2000) Primary liver resection and salvage transplantation or primary liver transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: an outcome-oriented decision analysis. Hepatology 31:899–906

    Article  CAS  PubMed  Google Scholar 

  93. Otto G, Heuschen U, Hofmann WJ, Krumm G, Hinz U, Herfarth C (1998) Survival and recurrence after liver transplantation versus liver resection for hepatocellular carcinoma: a retrospective analysis. Ann Surg. 227:424–432

    Article  CAS  PubMed  Google Scholar 

  94. Yamamoto J, Iwatsuki S, Kosuge T et al (1999) Should hepatomas be treated with hepatic resection or transplantation? Cancer 86:1151–1158

    Article  CAS  PubMed  Google Scholar 

  95. Belghiti J, Cortes A, Abdalla EK et al (2003) Resection prior to liver transplantation for hepatocellular carcinoma. Ann Surg. 238:885–892

    Article  PubMed  Google Scholar 

  96. Vauthey JN, Klimstra D, Franceschi D et al (1995) Factors affecting long-term outcome after hepatic resection for hepatocellular carcinoma. Am J Surg. 169:28–34

    Article  CAS  PubMed  Google Scholar 

  97. Nagorney DM, Adson MA, Weiland LH, Knight CD, Jr., Smalley SR, Zinsmeister AR (1985) Fibrolamellar hepatoma. Am J Surg. 149,:113–119

    Article  CAS  PubMed  Google Scholar 

  98. Soreide O, Czerniak A, Bradpiece H, Bloom S, Blumgart L (1986). Characteristics of fibrolamellar hepatocellular carcinoma. A study of nine cases and a review of the literature. Am J Surg. 151:518–523

    Article  CAS  PubMed  Google Scholar 

  99. Okuda K (2002) Natural history of hepatocellular carcinoma including fibrolamellar and hepato-cholangiocarcinoma variants. J Gastroenterol Hepatol 17:401–405

    Article  PubMed  Google Scholar 

  100. Hemming AW, Langer B, Sheiner P, Greig PD, Taylor BR (1997) Aggressive surg.ical management of fibrolamellar hepatocellular carcinoma. J Gastrointest Surg. 1:342–346

    Article  CAS  PubMed  Google Scholar 

  101. Ringe B, Wittekind C, Weimann A, Tusch G, Pichlmayr R (1992) Results of hepatic resection and transplantation for fibrolamellar carcinoma. Surg. Gynecol Obstet 175:299–305

    CAS  PubMed  Google Scholar 

  102. El-Gazzaz G, Wong W, El-Hadary MK et al (2000) Outcome of liver resection and transplantation for fibrolamellar hepatocellular carcinoma. Transpl Int 13 (Suppl 1):S406–S409

    Google Scholar 

  103. Pinna AD, Iwatsuki S, Lee RG et al (1997) Treatment of fibrolamellar hepatoma with subtotal hepatectomy or transplantation. Hepatology 26(4):877–883

    Article  CAS  PubMed  Google Scholar 

  104. Neuhaus P, Jonas S, Bechstein WO (2000) Hepatoma of the liver–resection or transplantation? Langenbecks Arch Surg. 385:171–178

    Article  CAS  PubMed  Google Scholar 

  105. Patt YZ, Hassan MM, Lozano RD et al (2003) Phase II trial of systemic continuous fluorouracil and subcutaneous recombinant interferon Alfa-2b for treatment of hepatocellular carcinoma. J Clin Oncol 21:421–427

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Daria Zorzi MD

  2. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Jean-Nicolas Vauthey & Eddie K. Abdalla MD

Authors
  1. Daria Zorzi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jean-Nicolas Vauthey
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eddie K. Abdalla MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Ambulatory Care Building, 2nd Floor, Department of Surgery, University of Louisville, S. Jackson Street 550, Louisville, 40202, Kentucky, USA

    Kelly M. McMasters

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Zorzi, D., Vauthey, JN., Abdalla, E.K. (2011). Liver Resection for Hepatocellular Carcinoma. In: McMasters, K. (eds) Hepatocellular Carcinoma:. Springer, New York, NY. https://doi.org/10.1007/978-1-60327-522-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-522-4_9

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-60327-521-7

  • Online ISBN: 978-1-60327-522-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation