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Immunoendocrinology: Scientific and Clinical Aspects pp 53–68Cite as

Characterizing T-Cell Autoimmunity

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Part of the book series: Contemporary Endocrinology ((COE))

Summary

Immunological mechanisms which precipitate autoimmune diabetes involve the influence of a genetic footprint on the phenotype of the T-cell response to self-antigens, and on development of pathological outcomes in immune responses resulting in T1D. For one of the human diabetes antigens, proinsulin, recent findings allow the emergence of a model in which elements of genetically biased T-cell development and peptide epitope-specific T-cell avidity result in expression of autoimmune disease. Understanding such self-reactive T-cell responses is key to implementation of specific immunotherapies for modulating disease risk and progression.

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Authors and Affiliations

  1. Benaroya Research Institute at Virginia Mason, Seattle, WA, USA

    Ivana Durinovic-Belló & Gerald T. Nepom

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  1. Ivana Durinovic-Belló
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  2. Gerald T. Nepom
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  1. Health Sciences Center, Children's Hospital, University of Colorado, East 9th Avenue 4200, Denver, 80262, Colorado, USA

    George S. Eisenbarth

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Durinovic-Belló, I., Nepom, G.T. (2011). Characterizing T-Cell Autoimmunity. In: Eisenbarth, G. (eds) Immunoendocrinology: Scientific and Clinical Aspects. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-478-4_4

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  • DOI: https://doi.org/10.1007/978-1-60327-478-4_4

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