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Anticoagulation

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Part of the book series: Aging Medicine ((AGME))

Abstract

Anticoagulation in the elderly can be very challenging. UFH, LMWH, and warfarin are effective first line agents for VTE prophylaxis in hip fracture patients. However, the use aspirin as a single agent after major orthopedic surgery is controversial, but more strongly favored by orthopedic surgeons. Differences in the approach taken by orthopaedic surgeons as compared to medical specialists have been discussed, and need to be further evaluated. There is often a greater fear of bleeding in the elderly due to age-associated risk, coexisting diseases, and polypharmacy that is appreciated by both orthopaedic surgeons and medical specialists alike. Intermittent compression devices may provide an added beneficial effect to other interventions, and carry no risk of bleeding.

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References

  1. Hull RD, Pineo GF, Francis C, et al. Low-molecular-weight heparin prophylaxis using dalteparin extended out-of-hospital vs in-hospital warfarin/out-of-hospital placebo in hip arthroplasty patients: a double-blind, randomized comparison. North American Fragmin Trial Investigators (see comment). Arch Intern Med. 2000 Jul;160(14):2208–15.

    Article  CAS  PubMed  Google Scholar 

  2. Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism: the seventh ACCP conference on antithrombotic and thrombolytic therapy (see comment). Chest. 2004 Sep;126(3 Suppl):338S–400S.

    Article  CAS  PubMed  Google Scholar 

  3. Lieberman DV, Lieberman D. Proximal deep vein thrombosis after hip fracture surgery in elderly patients despite thromboprophylaxis. Am J Phys Med Rehabil. 2002 Oct;81(10):745–50.

    Article  PubMed  Google Scholar 

  4. Kennedy JG, Soffe KE, Rogers BW, et al. Deep vein thrombosis prophylaxis in hip fractures: a comparison of the arteriovenous impulse system and aspirin. J Trauma. 2000 Feb;48(2):268–72.

    Article  CAS  PubMed  Google Scholar 

  5. Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin. Pulmonary embolism prevention (PEP) trial (see comment). Lancet. 2000 Apr;355(9212):1295–302.

    Google Scholar 

  6. Gent M, Hirsh J, Ginsberg JS, et al. Low-molecular-weight heparinoid orgaran is more effective than aspirin in the prevention of venous thromboembolism after surgery for hip fracture. Circulation. 1996 Jan;93(1):80–4.

    CAS  PubMed  Google Scholar 

  7. American Academy of Orthopaedic Surgeons. Clinical guideline on prevention of pulmonary embolism in patients undergoing total hip or knee arthroplasty. 2007 http://www.aaos.org/research/guidelines/PE_guideline.pdf Last accessed 4-3-10.

  8. Brown GA. Venous thromboembolism prophylaxis after major orthopaedic surgery: a pooled analysis of randomized controlled trials. J Arthroplasty. 2009;24: 77–83.

    Article  PubMed  Google Scholar 

  9. Morris GK, Mitchell JR. Prevention and diagnosis of venous thrombosis in patients with hip fractures. A survey of current practice. Lancet. 1976 Oct;2(7991):867–9.

    Article  CAS  PubMed  Google Scholar 

  10. Powers PJ, Gent M, Jay RM, et al. A randomized trial of less intense postoperative warfarin or aspirin therapy in the prevention of venous thromboembolism after surgery for fractured hip. Arch Intern Med. 1989 Apr;149(4):771–4.

    Article  CAS  PubMed  Google Scholar 

  11. Andersen JC. Advances in anticoagulation therapy: the role of selective inhibitors of factor Xa and thrombin in thromboprophylaxis after major orthopedic surgery. Semin Thromb Hemost. 2004 Dec;30(6):609–18.

    Article  CAS  PubMed  Google Scholar 

  12. Ketz J. Enoxaparin clinical pearl. Pharmacotherapy Update The Cleveland Clinic Center for Continuing Education. 2003;VI(1). Available at http://www.clevelandclinicmeded.com/medicalpubs/pharmacy/janfeb2003/enoxaparin.htm. Last accessed on November 10, 2010.

  13. Handoll HH, Sherrington C. Mobilisation strategies after hip fracture surgery in adults. Update of Cochrane Database Syst Rev. 2004;(4):CD001704; PMID: 15495015. Cochrane Database Syst Rev. 2007;(1):001704.

    Google Scholar 

  14. King CS, Holley AB, Jackson JL, et al. Twice vs three times daily heparin dosing for thromboembolism prophylaxis in the general medical population: a metaanalysis. Chest. 2007 Feb;131(2):507–16.

    Article  CAS  PubMed  Google Scholar 

  15. Pini M, Spyropoulos AC. Prevention of venous thromboembolism. Semin Thromb Hemost. 2006 Nov;32(8):755–66.

    Article  CAS  PubMed  Google Scholar 

  16. Jorgensen PS, Knudsen JB, Broeng L, et al. The thromboprophylactic effect of a low-molecular-weight heparin (fragmin) in hip fracture surgery. A placebo-controlled study. Clin Orthop. 1992 May;(278):95–100.

    Google Scholar 

  17. Monreal M, Lafoz E, Navarro A, et al. A prospective double-blind trial of a low molecular weight heparin once daily compared with conventional low-dose heparin three times daily to prevent pulmonary embolism and venous thrombosis in patients with hip fracture (see comment). J Trauma. 1989 Jun;29(6):873–5.

    Article  CAS  PubMed  Google Scholar 

  18. Gerhart TN, Yett HS, Robertson LK, et al. Low-molecular-weight heparinoid compared with warfarin for prophylaxis of deep-vein thrombosis in patients who are operated on for fracture of the hip. A prospective, randomized trial. J Bone Joint Surg Am. 1991 Apr;73(4):494–502.

    CAS  PubMed  Google Scholar 

  19. Senaran H, Acarolu E, Ozdemir HM, et al. Enoxaparin and heparin comparison of deep vein thrombosis prophylaxis in total hip replacement patients. Arch Orthop Trauma Surg. 2006 Jan;126(1):1–5.

    Article  PubMed  Google Scholar 

  20. Thaler HW, Roller RE, Greiner N, et al. Thromboprophylaxis with 60 mg enoxaparin is safe in hip trauma surgery. J Trauma. 2001 Sep;51(3):518–21.

    Article  CAS  PubMed  Google Scholar 

  21. Planes A, Vochelle N, Darmon JY, et al. Efficacy and safety of postdischarge administration of enoxaparin in the prevention of deep venous thrombosis after total hip replacement. A prospective randomised double-blind placebo-controlled trial. Drugs. 1996;52(Suppl 7):47–54.

    Article  PubMed  Google Scholar 

  22. Bijsterveld NR, Moons AH, Boekholdt SM, et al. Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers. Circulation. 2002 Nov;106(20):2550–4.

    Article  CAS  PubMed  Google Scholar 

  23. Bijsterveld NR, Vink R, van Aken BE, et al. Recombinant factor VIIa reverses the anticoagulant effect of the long-acting pentasaccharide idraparinux in healthy volunteers. Br J Haematol. 2004 Mar;124(5):653–8.

    Article  CAS  PubMed  Google Scholar 

  24. Eriksson BI, Bauer KA, Lassen MR, et al. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery (see comment). N Engl J Med. 2001 Nov;345(18):1298–304.

    Article  CAS  PubMed  Google Scholar 

  25. Gordois A, Posnett J, Borris L, et al. The cost-effectiveness of fondaparinux compared with enoxaparin as prophylaxis against thromboembolism following major orthopedic surgery. J Thromb Haemost. 2003 Oct;1(10):2167–74.

    Article  CAS  PubMed  Google Scholar 

  26. Eriksson BI, Lassen MR, PENTasaccharide in HIp-FRActure Surgery Plus, Investigators. Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery: a multicenter, randomized, placebo-controlled, double-blind study (see comment). Arch Intern Med. 2003 Jun;163(11):1337–42.

    Article  CAS  PubMed  Google Scholar 

  27. Grant PJ, Jaffer AK. When should prophylactic anticoagulation begin after a hip fracture? Cleve Clin J Med. 2006 788, 790–2; Sep;73(9):785–6.

    Google Scholar 

  28. Burnett RS, Clohisy JC, Wright RW, et al. Failure of the American college of chest physicians-1A protocol for lovenox in clinical outcomes for thromboembolic prophylaxis. J Arthroplasty. 2007 Apr;22(3):317–24.

    Article  PubMed  Google Scholar 

  29. Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin (see comment). N Engl J Med. 1995 May;332(20):1330–5.

    Article  CAS  PubMed  Google Scholar 

  30. Fisher CG, Blachut PA, Salvian AJ, et al. Effectiveness of pneumatic leg compression devices for the prevention of thromboembolic disease in orthopaedic trauma patients: a prospective, randomized study of compression alone versus no prophylaxis. J Orthop Trauma. 1995 Feb;9(1):1–7.

    Article  CAS  PubMed  Google Scholar 

  31. Westrich GH, Rana AJ, Terry MA, et al. Thromboembolic disease prophylaxis in patients with hip fracture: a multimodal approach. J Orthop Trauma. 2005 Apr;19(4):234–40.

    Article  PubMed  Google Scholar 

  32. Rice KL, Walsh ME. Minimizing venous thromboembolic complications in the orthopaedic patient. Orthop Nurs. 2001 Nov–Dec;20(6):21–7.

    Article  CAS  PubMed  Google Scholar 

  33. Merli GJ. Prevention of thrombosis with warfarin, aspirin, and mechanical methods. Clin Cornerstone. 2005;7(4):49–56.

    Article  PubMed  Google Scholar 

  34. Pitto RP, Hamer H, Heiss-Dunlop W, et al. Mechanical prophylaxis of deep-vein thrombosis after total hip replacement a randomised clinical trial. J Bone Joint Surg Br. 2004 Jul;86(5):639–42.

    Article  CAS  PubMed  Google Scholar 

  35. Vaughn BK, Knezevich S, Lombardi AV Jr, et al. Use of the Greenfield filter to prevent fatal pulmonary embolism associated with total hip and knee arthroplasty. J Bone Joint Surg Am. 1989 Dec;71(10):1542–8.

    CAS  PubMed  Google Scholar 

  36. Austin MS, Parvizi J, Grossman S, et al. The inferior vena cava filter is effective in preventing fatal pulmonary embolus after hip and knee arthroplasties. J Arthroplasty. 2007 Apr;22(3):343–8.

    Article  PubMed  Google Scholar 

  37. Jaff MR, Goldhaber SZ, Tapson VF. High utilization rate of vena cava filters in deep vein thrombosis. Thromb Haemost. 2005 Jun;93(6):1117–9.

    CAS  PubMed  Google Scholar 

  38. Johanson NA, Lachiewicz PF, et al. AAOS Clinical Practice Guideline Summary. Prevention of symptomatic pulmonary embolism in patients undergoing total hip or knee arthroplasty. J Am Acad Orthop Surg. 2009 March;17:183–96.

    PubMed  Google Scholar 

  39. Eikelboom JW, Karthikeyan G, et al. American Association of Orthopedic Surgeons and American College of Chest Physicians guidelines for venous thromboembolism prevention in hip and knee arthroplasty differ: what are the implications for clinicians and patients? Chest 2009 Feb;135:513–20.

    Article  PubMed  Google Scholar 

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Walsh, K., Bruza, J. (2011). Anticoagulation. In: Pignolo, R., Keenan, M., Hebela, N. (eds) Fractures in the Elderly. Aging Medicine. Humana Press. https://doi.org/10.1007/978-1-60327-467-8_5

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  • DOI: https://doi.org/10.1007/978-1-60327-467-8_5

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