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The Cerebellum

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Neuroscience in Medicine

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References

  • Ackermann H, Mathiak K, Riecker A. The contribution of the cerebellum to speech production and speech perception: Clinical and functional imaging data. The Cerebellum 2007; 6(3):202–213.

    Google Scholar 

  • Adams JH, Corsellis JAN, Duchen LW (eds). Greenfield’s Neuropathology. New York: John Wiley & Sons, 1984.

    Google Scholar 

  • Alder J, Cho NK, Hatten ME. Embryonic precursor cells from the rhombic lip are specified to a cerebellar granule neuron identity. Neuron 1996; 17:389–399.

    Article  PubMed  CAS  Google Scholar 

  • Allin M, Matsumoto H, Santhouse AM, Nosarti C, AI-Asady MH, Sterwart AL, Rifkin L, Murray RM. Cognitive and motor function and the size of the cerebellum in adolescents born very pre-term. Brain 2001; 124(Pt 1):60–66.

    Article  PubMed  CAS  Google Scholar 

  • Altman J, Bayer SA. Development of the Cerebellar System in Relation to Its Evolution, Structure, and Functions. Boca Raton, FL: CRC Press, 1997.

    Google Scholar 

  • Bellebaum C, Daum I. Cerebellar involvement in executive control. The Cerebellum 2007; 6(3):154–192.

    Google Scholar 

  • Brodal A. Neurological Anatomy in Relation to Clinical Medicine. New York: Oxford University Press, 1981.

    Google Scholar 

  • Chen SHA, Desmond JE. Temporal dynamics of cerebro-cerebellar network recruitment during a cognitive task. Neuropsychologia 2005; 43(9):1227–1237.

    Article  PubMed  Google Scholar 

  • Christian KM, Thompson RF. Neural substrates of eyeblink conditioning: acquisition and retention. Learn Mem 2003; 10(6):427–455.

    Article  PubMed  Google Scholar 

  • Christian KM, Thompson RF. Long-term storage of an associative memory trace in the cerebellum. Behav Neurosci 2005; 119(2):526–537.

    Article  PubMed  Google Scholar 

  • Coffin JM, Baroody S, Schneider K, O'Neill J. Impaired cerebellar learning in children with prenatal alcohol exposure: a comparative study of eyeblink conditioning in children with ADHD and dyslexia. Cortex 2005; 41:389–398.

    Article  PubMed  Google Scholar 

  • De Smet HJ, Baillieuxa H, De Deync PP, Mariëna P, Paquier P. The cerebellum and language: The story so far. Folia Phoniatrica et Logopaedica 2007; 59:165–170.

    Article  PubMed  Google Scholar 

  • Desmond JE, Chen SHA, Shieh PB. Cerebellar transcranial magnetic stimulation impairs verbal working memory. Ann Neurol 2005; 58(4):553–560.

    Article  PubMed  Google Scholar 

  • Desmond JE, Fiez JA. Neuroimaging studies of the cerebellum: Language, learning and memory. Trends in Cognitive Sciences 1998; 29(9):355–362.

    Article  Google Scholar 

  • Dobbing J. The later development of the brain. Scientific Foundations of Paediatrics. Davis JA, Dobbing J. Philadelphia: Saunders, 744–759, 1981.

    Google Scholar 

  • Dow RS, Moruzzi G. The Physiology and Pathology of the Cerebellum. Minneapolis: University of Minnesota Press, 1958.

    Google Scholar 

  • Eccles JC, Ito M, Szentágothai J. The Cerebellum as a Neuronal Machine. New York: Springer-Verlag, 1967.

    Google Scholar 

  • Gerwig M, Kolb FP, Timmann D. The involvement of the human cerebellum in eyeblink conditioning. The Cerebellum 2007; 6(1):38–57.

    Article  PubMed  CAS  Google Scholar 

  • Gilman S. Cerebellum and Motor Dysfunction. Diseases of the Nervous System. Asbury AK, McKhann GM, McDonals W. London: William Heinemann Medical Books, Ltd. I:401–422, 1986.

    Google Scholar 

  • Gilman S, Bloedel JR, Lechtenberg R. Disorders of the Cerebellum. Philadelphia: Davis, 1981.

    Google Scholar 

  • Glickstein M, Waller J, Baizer JS, Brown B, Timmann D. Cerebellum lesions and finger use. Cerebellum 2005; 4(3):189–197.

    Article  PubMed  Google Scholar 

  • Gluhbegovic N, Williams TH. The Human Brain: A Photographic Guide. Hagerstown, MD: Harper & Row Publishers, Inc., 1980.

    Google Scholar 

  • Green JT. The effects of ethanol on the developing cerebellum and eyeblink classical conditioning. Cerebellum 2004; 3:178–187.

    Article  PubMed  CAS  Google Scholar 

  • Hatten ME. New directions in neuronal migration. Science 2002; 297(5587):1660–1663.

    Article  PubMed  CAS  Google Scholar 

  • Holmes G. The cerebellum of man. Brain 1939; 62:1–30.

    Article  Google Scholar 

  • Ito M. The Cerebellum and Neural Control. New York: Raven Press, 1984

    Google Scholar 

  • Ito M. Cerebellar circuitry as a neuronal machine. Prog Neurobiol 2006; 78(3–5):272–303.

    Article  PubMed  Google Scholar 

  • Ivry RB, Spencer RMC. The neural representation of time. Curr Opin Neurobiol 2004; 14(2):225–232.

    Article  PubMed  CAS  Google Scholar 

  • Jorntell H, Hansel C. Synaptic memories upside down: Bidirectional plasticity at cerebellar parallel fiber-Purkinje cell synapses. Neuron 2006; 52(2):227–238.

    Article  PubMed  Google Scholar 

  • Kelly RM, Strick PL. Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. J Neurosci 2003; 23(23):8432–8444.

    PubMed  CAS  Google Scholar 

  • Kim JJ, Thompson RF. Cerebellar circuits and synaptic mechanisms involved in classical eyeblink conditioning. Trends Neurosci 1997; 20(4):177–182.

    Article  PubMed  CAS  Google Scholar 

  • Kleim JA, Freeman JH Jr, Bruneau R, Nolan BC, Cooper NR, Zook A, Walters D. Synapse formation is associated with memory storage in the cerebellum. Proc Natl Acad Sci USA 2002; 99(20):13228–13231.

    Article  PubMed  CAS  Google Scholar 

  • Larsell O. Anatomy of the Nervous System. New York: Appleton-Century-Crofts, Inc., 1951.

    Google Scholar 

  • Lavond DG, Kim JJ, Thompson RF. Mammalian brain substrates of aversive classical conditioning. Annu Rev Psychol 1993; 44:317–342.

    Article  PubMed  CAS  Google Scholar 

  • Martin TA, Keating JG, Goodkin HP, Bastian AJ, Thach WT. Throwing while looking through prisms: I. Focal olivocerebellar lesions impair adaptation. Brain 1996; 119(4):1183–1198.

    Article  PubMed  Google Scholar 

  • McGlinchey-Berroth R, Cermak LS, Carrillo MC, Armfield S, Gabrieli JD, Disterhoft JF. Impaired delay eyeblink conditioning in amnesic Korsakoff's patients and recovered alcoholics. Alcohol Clin Exp Res 1995; 19:1127–1132.

    Article  PubMed  CAS  Google Scholar 

  • Medina JF, Nores WL, Ohyama T, Mauk MD. Mechanisms of cerebellar learning suggested by eyelid conditioning. Curr Opin Neurobiol 2000; 10(6):717–724.

    Article  PubMed  CAS  Google Scholar 

  • Miller MJ, Chen N-K, Li L, Tom B, Weiss C, Disterhoft JF, Wyrwicz AM. fMRI of the conscious rabbit during unilateral classical eyeblink conditioning reveals bilateral cerebellar activation. J Neurosci 2003; 23(37):11753–11758.

    PubMed  CAS  Google Scholar 

  • Morton SM, Bastian AJ. Mechanisms of cerebellar gait ataxia. The Cerebellum 2007; 6(1):79 – 86.

    Article  PubMed  Google Scholar 

  • Nunzi MG, Birnstiel S, Bhattacharyya BJ, Slater NT, Mugnaini E. Unipolar brush cells form a glutamatergic projection system within the mouse cerebellar cortex. J Comp Neurol 2001; 434:329–341.

    Article  PubMed  CAS  Google Scholar 

  • Ohyama T, Nores WL, Murphy M, Mauk MD. What the cerebellum computes. Trends Neurosci 2003; 26(4):222–227.

    Article  PubMed  CAS  Google Scholar 

  • Ravizza SM, McCormick CA, Schlerf JE, Justus T, Ivry RB, Fiez JA. Cerebellar damage produces selective deficits in verbal working memory. Brain 2006; 129:306–320.

    Article  PubMed  Google Scholar 

  • Riva D, Giorgi C. The cerebellum contributes to higher functions during development: evidence from a series of children sur¬gically treated for posterior fossa tumours. Brain 2000; 123(Pt 5):1051–1061.

    Article  PubMed  Google Scholar 

  • Sahin M, Hockfield S. Molecular identification of Lugaro cells in the cat cerebellar cortex. J Comp Neurol 1990; 301:575–584.

    Article  PubMed  CAS  Google Scholar 

  • Schmahmann JD (ed). The Cerebellum and Cognition. International Review of Neurobiology. San Diego:Academic Press, 1997.

    Google Scholar 

  • Schmahmann JD. Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J Neuropsychiatry Clin Neurosci 2004; 16(3):367–378.

    Article  PubMed  Google Scholar 

  • Schmahmann JD, Pandya DN. The cerebrocerebellar system. Int Rev Neurobiol 1997; 47:31–60.

    Article  Google Scholar 

  • Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain 1998; 121:561–579.

    Article  PubMed  Google Scholar 

  • Schweighofer N, Doya K, Kuroda S. Cerebellar aminergic neuromodulation: towards a functional understanding. Brain Res Rev 2004; 44(2–3):103–116.

    Article  PubMed  Google Scholar 

  • Sekerkova G, Ilijic E, Mugnaini E. Time of origin of unipolar brush cells in the rat cerebellum as observed by prenatal bromodeoxyuridine labeling. Neuroscience 2004; 127(4):845–858.

    Article  PubMed  CAS  Google Scholar 

  • Silveri MC, Di Betta AM, Filippini V, Leggio MG, Molinari M. Verbal short-term store-rehearsal system and the cerebellum. Evidence from a patient with a right cerebellar lesion. Brain 1998; 121 (11):2175–2187.

    Article  PubMed  Google Scholar 

  • Sotelo C. Cellular and genetic regulation of the development of the cerebellar system. Prog Neurobiol 2004; 72(5):295–339.

    Article  PubMed  CAS  Google Scholar 

  • Spencer RMC, Ivry RB, Zelaznik HN. Role of the cerebellum in movements: control of timing or movement transitions? Exp Brain Res 2005; 161:383–396.

    Article  PubMed  Google Scholar 

  • Spencer RMC, Zelaznik HN, Diedrichsen J, Ivry RB. Disrupted timing of discontinuous but not continuous movements by cerebellar lesions. Science 2003; 300(5624):1437–1439.

    Article  PubMed  CAS  Google Scholar 

  • Thach WT. A role for the cerebellum in learning movement coordination. Neurobiol Learn Mem 1998; 70:177–188.

    Article  PubMed  CAS  Google Scholar 

  • Thach WT, Bastian AJ. Role of the cerebellum in the control and adaptation of gait in health and disease. Prog Brain Res 2004; 143:353–366.

    Article  PubMed  Google Scholar 

  • Thompson RF. The neurobiology of learning and memory. Science 1986; 233:941–947.

    Article  PubMed  CAS  Google Scholar 

  • Thompson RF, Kim JJ. Memory systems in the brain and localization of a memory. Proc Natl Acad Sci USA 1996; 93:13438–13444.

    Article  PubMed  CAS  Google Scholar 

  • Voogd J, Glickstein M. The anatomy of the cerebellum. Trends Neurosci 1998; 21(9):370–375.

    Article  PubMed  CAS  Google Scholar 

  • West JR (ed). Alcohol and Brain Development. New York: Oxford University Press, 1986.

    Google Scholar 

  • Woodruff-Pak DS, Steinmetz JE (eds). Eyeblink Classical Conditioning: Volume I - Applications in Humans Boston: Kluwer Academic Publishers, 2000a.

    Google Scholar 

  • Woodruff-Pak DS, Steinmetz JE (eds). Eyeblink Classical Conditioning: Volume II - Animal Models. Boston: Kluwer Academic Publishers, 2000b.

    Google Scholar 

  • Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X. PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development 2005; 132(14):3281–3291.

    Article  PubMed  CAS  Google Scholar 

  • Zecevic N, Rakic P. Differentiation of Purkinje cells and their relationship to other components of developing cerebellar cortex in man. J Comp Neurol 1976; 167:27–48.

    Article  PubMed  CAS  Google Scholar 

  • Zhang L, Goldman JE. Generation of cerebellar interneurons from dividing progenitors in white matter. Neuron 1996; 16(1):47–54.

    Article  PubMed  Google Scholar 

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Acknowledgments

This work represents a revision and extension of the chapter that appeared in the 2nd edition of Neuroscience in Medicine, authored by James R. West and John B. Geldard. Substantial portions of the text and most of the figures of their previous chapter were retained, some with modification. The author assumes full responsibility for the current version of this chapter.

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Authors and Affiliations

  1. Department of Psychology and Program in Medical Neuroscience, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA

    Charles R. Goodlett PhD

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  1. Charles R. Goodlett PhD
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Editors and Affiliations

  1. Oregon National Primate Research Center, Div. Neuroscience, Oregon Health and Science University, 505 NW 185th Ave, Beaverton OR 97006, USA

    P. Michael Conn

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© 2008 Humana Press, Totowa, NJ

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Goodlett, C.R. (2008). The Cerebellum. In: Conn, P.M. (eds) Neuroscience in Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-455-5_14

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