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Biennial Review of Infertility pp 3–20Cite as

Environmental Factors Affecting Female Infertility

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Abstract

There is increasing concern about the effects of environmental contaminants on reproductive health. While there are limited clinical data regarding most chemical exposures and human reproduction, studies in laboratory animal models and wildlife under- score the vulnerability of the reproductive system to many environmental insults at different times of development and across the life cycle. Here, we review data implicating select environmental contaminants in compromised reproductive capacity in animals. We also review epidemiologic data in humans that suggest roles for environmental contaminants in reproductive dysfunction and infertility.

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References

  1. Caserta D, Maranghi L, Mantovani A, Marci R, Maranghi F, Moscarini M. Impact of Endocrine Disruptor Chemicals in Gynaecology. Hum Reprod Update 2008;14:59–72.

    PubMed  CAS  Google Scholar 

  2. Fenton SE. Endocrine-Disrupting Compounds and Mammary Gland Development: Early Exposure and Later Life Consequences. Endocrinology 2006;147:s18–24.

    PubMed  CAS  Google Scholar 

  3. McLachlan JA. Environmental Signaling: What Embryos and Evolution Teach Us About Endocrine Disrupting Chemicals. Endocr Rev 2001;22:319–41.

    PubMed  CAS  Google Scholar 

  4. Woodruff TJ, Carlson A, Schwartz JM, Giudice LC. Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: Executive Summary. Fertility and Sterility 2008;89:281–300.

    PubMed  Google Scholar 

  5. Sanderson JT. The Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals. Toxicol Sci 2006;94:3–21.

    PubMed  CAS  Google Scholar 

  6. Arisawa K, Matsumura T, Tohyama C, et al. Fish Intake, Plasma Omega-3 Polyunsaturated Fatty Acids, and Poly-chlorinated Dibenzo-p-dioxins/Polychlorinated Dibenzo-furans and Co-Planar Polychlorinated Biphenyls in the Blood of the Japanese Population. Int Arch Occup Environ Health 2003;76:205–15.

    PubMed  CAS  Google Scholar 

  7. Hightower JM, Moore D. Mercury Levels In High-End Consumers of Fish. Environ Health Perspect 2003;111:604–8.

    PubMed  CAS  Google Scholar 

  8. Ornaghi F, Ferrini S, Prati M, Giavini E. The Protective Effects of N-Acetyl-L-Cysteine Against Methyl Mercury Embryotoxicity In Mice. Fundam Appl Toxicol 1993;20: 437–45.

    PubMed  CAS  Google Scholar 

  9. Alm H, Torner H, Tiemann U, Kanitz W. Influence of Organochlorine Pesticides on Maturation and Postfertilization Development of Bovine Oocytes In Vitro. Reprod Toxicol 1998;12:559–63.

    PubMed  CAS  Google Scholar 

  10. Campagna C, Sirard M-A, Ayotte P, Bailey JL. Impaired Maturation, Fertilization, and Embryonic Development of Porcine Oocytes Following Exposure to an Environmentally Relevant Organochlorine Mixture. Biol Reprod 2001;65: 554–60.

    PubMed  CAS  Google Scholar 

  11. Krogenaes AK, Nafstad I, Skåre JU, Farstad W, Hafne AL. In Vitro Reproductive Toxicity of Polychlorinated Biphenyl Congeners 153 and 126. Reprod Toxicol 1998; 12:575–80.

    PubMed  CAS  Google Scholar 

  12. De Luca-Abbott SB, Wong BS, Peakall DB, et al. Review of Effects of Water Pollution on the Breeding Success of Waterbirds, with Particular Reference to Ardeids in Hong Kong. Ecotoxicol Environ Saf 2001;10:327–49.

    CAS  Google Scholar 

  13. Guillette LJ, Jr, Edwards TM. Environmental Influences on Fertility: Can We Learn Lessons from Studies of Wildlife? Fertil Steril 2008;89:e21–e4.

    PubMed  Google Scholar 

  14. Guillette LJJ, Moore BC. Environmental Contaminants, Fertility, and Multioocytic Follicles: A Lesson from Wildlife? Semin Reprod Med 2006;24:134–41.

    PubMed  CAS  Google Scholar 

  15. Windham G, Fenster L. Environmental Contaminants and Pregnancy Outcomes. Fertil Steril 2008;89:e111–e6.

    PubMed  Google Scholar 

  16. Gajalakshmi GK, Jha P, Ranson K, Nguyen S. Global patterns of smoking, and smoking-attributable mortality. In P Jha & F Chalouka (eds.), Tobacco Control in Developing Countries. Oxford: Oxford Medical Publications 2000:11–40.

    Google Scholar 

  17. Brunnemann KD, Hoffmann D. Analytical Studies on Tobacco-Specific N-Nitrosamines in Tobacco and Tobacco Smoke. Crit Rev Toxicol 1991;21:235–40.

    PubMed  CAS  Google Scholar 

  18. Bolumar F, Olsen J, Rebagliato M, et al. Body Mass Index and Delayed Conception: A European Multicenter Study on Infertility and Subfecundity. Am J Epidemiol 2000;151: 1072–9.

    PubMed  CAS  Google Scholar 

  19. Curtis KM, Savitz DA, Arbuckle TE. Effects of Cigarette Smoking, Caffeine Consumption, and Alcohol Intake on Fecundability. Am J Epidemiol 1997;146:32–41.

    PubMed  CAS  Google Scholar 

  20. Hull MGR, North K, Taylor H, Farrow A, Ford WC. Delayed Conception and Active and Passive Smoking. Fertil Steril 2000;74:725–33.

    PubMed  CAS  Google Scholar 

  21. Spinelli A, Figa-Talamanca I, Osborn J. Time to Pregnancy and Occupation In A Group of Italian Women. Int J Epidemiol 1997;26:601–9.

    PubMed  CAS  Google Scholar 

  22. The Practice Committee of the American Society of Reproductive Medicine. Smoking and infertility. Fertil Steril 2006;86:S172–S7.

    Google Scholar 

  23. Augood C, Duckitt K, Templeton AA. Smoking and Female Infertility: A Systematic Review and Meta-Analysis. Hum Reprod 1998;13:1532–9.

    PubMed  CAS  Google Scholar 

  24. Klonoff-Cohen H. Female and Male Lifestyle Habits and IVF: What Is Known and Unknown. Hum Reprod Update 2005;11:180–204.

    Google Scholar 

  25. El-Nemr A, Al-Shawaf T, Sabatini L, Wilson C, Lower AM, Grudzinskas JG. Effect of Smoking on Ovarian Reserve and Ovarian Stimulation In In Vitro Fertilization and Embryo Transfer. Hum Reprod 1998;13:2192–8.

    PubMed  CAS  Google Scholar 

  26. Freour T, Masson D, Mirallie S, et al. Active Smoking Compromises IVF Outcome and Affects Ovarian Reserve. Reprod Biomed Online 2008;16:96–102.

    PubMed  Google Scholar 

  27. Hughes EG, Brennan BG. Does Cigarette Smoking Impair Natural or Assisted Fecundity? Fertil Steril 1996;66: 679–89.

    PubMed  CAS  Google Scholar 

  28. Lintsen AME, Pasker-de Jong PCM, de Boer EJ, et al. Effects of Subfertility Cause, Smoking and Body Weight on the Success Rate of IVF. Hum Reprod 2005;20:1867–75.

    PubMed  CAS  Google Scholar 

  29. Zenzes MT, Reed TE, Casper RF. Effects of Cigarette Smoking and Age on the Maturation of Human Oocytes. Hum Reprod 1997;12:1736–41.

    PubMed  CAS  Google Scholar 

  30. Zenzes MT, Wang P, Casper RF. Cigarette Smoking May Affect Meiotic Maturation of Human Oocytes. Hum Reprod 1995;10:3213–7.

    PubMed  CAS  Google Scholar 

  31. Soares SR, Simon C, Remohi J, Pellicer A. Cigarette Smoking Affects Uterine Receptiveness. Hum Reprod 2007; 22:543–7.

    PubMed  CAS  Google Scholar 

  32. Neal MS, Hughes EG, Holloway AC, Foster WG. Sidestream Smoking Is Equally As Damaging As Mainstream Smoking on IVF Outcomes. Hum Reprod 2005;20:2531–5.

    PubMed  Google Scholar 

  33. Zenzes MT. Smoking and Reproduction: Gene Damage to Human Gametes and Embryos. Hum Reprod Update 2000;6:122–31.

    PubMed  CAS  Google Scholar 

  34. Ness RB, Grisso JA, Hirschinger N, et al. Cocaine and Tobacco Use and the Risk of Spontaneous Abortion. N Engl J Med 1999;340:333–9.

    PubMed  CAS  Google Scholar 

  35. Winter E, Wang J, Davies MJ, Norman R. Early Pregnancy Loss Following Assisted Reproductive Technology Treat­ment. Hum Reprod 2002;17:3220–3.

    PubMed  Google Scholar 

  36. Chatenoud L, Parazzini F, Di Cintio E, et al. Paternal and Maternal Smoking Habits before Conception and During the First Trimester: Relation to Spontaneous Abortion. Ann Epidemiol 1998;8:520–6.

    PubMed  CAS  Google Scholar 

  37. Maconochie N, Doyle P, Prior S, Simmons R. Risk Factors for First Trimester Miscarriage–Results from a UK-Population-Based Case-Control Study. BJOG: Int J Obstet Gynaecol 2007;114:170–86.

    CAS  Google Scholar 

  38. Nielsen A, Hannibal CG, Lindekilde BE, et al. Maternal Smoking Predicts the Risk of Spontaneous Abortion. Acta Obstetricia et Gynecologica Scandinavica 2006;85: 1057–65.

    PubMed  Google Scholar 

  39. Rasch V. Cigarette, Alcohol, and Caffeine Consumption: Risk Factors for Spontaneous Abortion. Acta Obstetricia et Gynecologica Scandinavica 2003;82:182–8.

    PubMed  Google Scholar 

  40. Windham GC, Swan SH, Fenster L. Parental Cigarette Smoking and the Risk of Spontaneous Abortion. Am J Epidemiol 1992;135:1394–403.

    PubMed  CAS  Google Scholar 

  41. Coste J, Bouyer J, Ughetto S, et al Ectopic Pregnancy Is Again on the Increase. Recent Trends in the Incidence of Ectopic Pregnancies in France (1992–2002). Hum Reprod 2004;19:2014–8.

    PubMed  Google Scholar 

  42. Coste J, Job-Spira N, Fernandez H. Increased Risk of Ectopic Pregnancy with Maternal Cigarette Smoking. Am J Public Health 1991;81:199–201.

    PubMed  CAS  Google Scholar 

  43. Coste J, Job-Spira N, Fernandez H, Papiemik E, Spira A. Risk Factors for Ectopic Pregnancy: A Case-Control Study in France, with Special Focus on Infectious Factors. Am J Epidemiol 1991;133:839–49.

    PubMed  CAS  Google Scholar 

  44. Karaer A, Avsar FA, Batioglu S. Risk Factors for Ectopic Pregnancy: A Case-Control Study. Aust N Z J Obstet Gynaecol 2006;46:521–7.

    PubMed  Google Scholar 

  45. Knoll M, Shaoulian R, Magers T, Talbot P. Ciliary Beat Frequency of Hamster oviducts Is Decreased in vitro by Exposure to Solutions of Mainstream and Sidestream Cigarette Smoke. Biol Reprod 1995;53:29–37.

    PubMed  CAS  Google Scholar 

  46. Knoll M, Talbot P. Cigarette Smoke Inhibits Oocyte Cumulus Complex Pick-Up by the Oviduct In Vitro Independent of Ciliary Beat Frequency. Reprod Toxicol 1998;12:57–68.

    PubMed  CAS  Google Scholar 

  47. Riveles K, Iv M, Arey J, Talbot P. Pyridines in Cigarette Smoke Inhibit Hamster Oviductal Functioning in Picomolar Doses. Reprod Toxicol 2003;17:191–202.

    PubMed  CAS  Google Scholar 

  48. Riveles K, Roza R, Arey J, Talbot P. Pyrazine Derivatives in Cigarette Smoke Inhibit Hamster Oviductal Functioning. Reprod Biol Endocrinol 2004;2:23.

    PubMed  Google Scholar 

  49. Riveles K, Roza R, Talbot P. Phenols, Quinolines, Indoles, Benzene, and 2-Cyclopenten-1-ones are Oviductal Toxicants in Cigarette Smoke. Toxicol Sci 2005;86:141–51.

    PubMed  CAS  Google Scholar 

  50. Benowitz NL, Kuyt F, Jacob P, Jones RT. Cotinine Disposition and Effects. Clin Pharmacol Ther 1983;34: 604–11.

    PubMed  CAS  Google Scholar 

  51. Weiss T, Eckert A. Cotinine Levels in Follicular Fluid and Serum of IVF Patients: Effect on Granulosa-Luteal Cell Function In Vitro. Hum Reprod 1989;4:482–5.

    PubMed  CAS  Google Scholar 

  52. Zenzes MT, Krishnan S, Krishnan B, Zhang H, Casper RF. Cadmium Accumulation in Follicular Fluid of Women in In Vitro Fertilization-Embryo Transfer Is Higher In Smokers. Fertil Steril 1995;64:599–603.

    PubMed  CAS  Google Scholar 

  53. Zenzes MT, Reed TE, Wang P, Klein J. Cotinine, A Major Metabolite of Nicotine, Is Detectable in Follicular Fluids of Passive Smokers in In Vitro Fertilization Therapy. Fertil Steril 1996;66:614–9.

    PubMed  CAS  Google Scholar 

  54. Bartsch H, Nair U, Risch A, Rojas M, Wikman H, Alexandrov K. Genetic Polymorphism of CYP Genes, Alone or in Combination, as a Risk Modifier of Tobacco-related Cancers. Cancer Epidemiol Biomarkers Prev 2000;9: 3–28.

    PubMed  CAS  Google Scholar 

  55. Archibong AE, Inyang F, Ramesh A, et al. Alteration of Pregnancy Related Hormones and Fetal Survival in F-344 Rats Exposed by Inhalation to Benzo(a)pyrene. Reprod Toxicol 2002;16:801–8.

    PubMed  CAS  Google Scholar 

  56. Kristensen P, Eilertsen E, Einarsdóttir E, Haugen A, Skaug V, Ovrebø S. Fertility in Mice After Prenatal Exposure to Benzo[a]pyrene and Inorganic Lead. Environ Health Perspect 1995;103:588–90.

    PubMed  CAS  Google Scholar 

  57. Buters J, Quintanilla-Martinez L, Schober W, et al. CYP1B1 Determines Susceptibility to Low Doses of 7,12-Dimethylbenz [a]anthracene-Induced Ovarian Cancers in Mice: Correlation of CYP1B1-Mediated DNA Adducts with Carcinogenicity. Carcinogenesis 2003;24:327–34.

    PubMed  CAS  Google Scholar 

  58. Goodman MT, McDuffie K, Kolonel LN, et al. Case-Control Study of Ovarian Cancer and Polymorphisms in Genes Involved in Catecholestrogen Formation and Metabolism. Cancer Epidemiol Biomarkers Prev 2001;10:209–16.

    PubMed  CAS  Google Scholar 

  59. Vidal JD, VandeVoort CA, Marcus CB, Lazarewicz NR, Conley AJ. In Vitro Exposure to Environmental Tobacco Smoke Induces CYP1B1 Expression in Human Luteinized Granulosa Cells. Reprod Toxicol 2006;22:731–7.

    PubMed  CAS  Google Scholar 

  60. Wang X, Zuckerman B, Pearson C, et al. Maternal Cigarette Smoking, Metabolic Gene Polymorphism, and Infant Birth Weight. JAMA 2002;287:195–202.

    PubMed  CAS  Google Scholar 

  61. Harlow BL, Signorello LB. Factors Associated with Early Menopause. Maturitas 2000;35:3–9.

    PubMed  CAS  Google Scholar 

  62. Kinney A, Kline J, Levin B. Alcohol, Caffeine and Smoking in Relation to Age at Menopause. Maturitas 2006;54: 27–38.

    PubMed  CAS  Google Scholar 

  63. Mikkelsen T, Graff-Iversen S, Sundby J, Bjertness E. Early Menopause, Association with Tobacco Smoking, Coffee Consumption and Other Lifestyle Factors: A Cross-Sectional Study. BMC Public Health 2007;7:149.

    PubMed  Google Scholar 

  64. Sharara FI, Beatse SN, Leonardi MR, Navot D, Scott RTJ. Cigarette Smoking Accelerates the Development of Diminished Ovarian Reserve As Evidenced by the Clomiphene Citrate Challenge Test. Fertil Steril 1994;62:257–62.

    PubMed  CAS  Google Scholar 

  65. Backer LC, Rubin CS, Marcus M, Kieszak SM, Schober SE. Serum Follicle-Stimulating Hormone and Luteinizing Hormone Levels in Women Aged 35–60 in the U.S. Population: The Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994). Menopause 1999;6(1):29–35.

    PubMed  CAS  Google Scholar 

  66. Cramer DW, Barbieri RL, Fraer AR, Harlow BL. Determinants of Early Follicular Phase Gonadotrophin and Estradiol Concentrations in Women of Late Reproductive Age. Hum Reprod 2002;17:221–7.

    PubMed  CAS  Google Scholar 

  67. Kinney A, Kline J, Kelly A, Reuss ML, Levin B. Smoking, Alcohol and Caffeine in Relation to Ovarian Age During the Reproductive Years. Hum Reprod 2007;22:1175–85.

    PubMed  CAS  Google Scholar 

  68. Hoyer PB, Sipes IG. Assessment of Follicle Destruction in Chemical-Induced Ovarian Toxicity. Annu Rev Pharmacol Toxicol 1996;36:307–31.

    PubMed  CAS  Google Scholar 

  69. Mattison DR. Difference in Sensitivity of Rat and Mouse Primordial Oocytes to Destruction by Polycyclic Aromatic Hydrocarbons. Chemico-Biological Interactions 1979;28: 133–7.

    PubMed  CAS  Google Scholar 

  70. Mattison DR. Morphology of Oocyte and Follicle Destruction by Polycyclic Aromatic Hydrocarbons in Mice. Toxicol Appl Pharmacol 1980;53:249–59.

    PubMed  CAS  Google Scholar 

  71. Mattison DR, Shiromizu K, Nightingale MS. Oocyte Destruction by Polycyclic Aromatic Hydrocarbons. Am J Ind Med 1983;4:191–202.

    PubMed  CAS  Google Scholar 

  72. Matikainen T, Perez GI, Jurisicova A, et al. Aromatic Hydrocarbon Receptor-Driven Bax Gene Expression is Required for Premature Ovarian Failure Caused by Biohazardous Environmental Chemicals. Nat Genet 2001;28: 355–60.

    PubMed  CAS  Google Scholar 

  73. Matzuk MM. Eggs in the Balance. Nat Genet 2001;28: 300–1.

    PubMed  CAS  Google Scholar 

  74. Nardo LG, Christodoulou D, Gould D, Roberts SA, Fitzgerald CT, Laing I. Anti-Mullerian Hormone Levels and Antral Follicle Count in Women Enrolled in In Vitro Fertilization Cycles: Relationship to Lifestyle Factors, Chronological Age and Reproductive History. Gynecol Endocrinol 2007;23:486–93.

    PubMed  CAS  Google Scholar 

  75. Barker DJ, Clark PM. Fetal Undernutrition and Disease in Later Life. Rev Reprod 1997;2:105–12.

    PubMed  CAS  Google Scholar 

  76. Barker DJP. Maternal Nutrition, Fetal Nutrition, and Disease in Later Life. Nutrition 1997;13:807–13.

    PubMed  CAS  Google Scholar 

  77. Osmond C, Barker DJ. Fetal, Infant, and Childhood Growth are Predictors of Coronary Heart Disease, Diabetes, and Hypertension in Adult Men and Women. Environ Health Perspect 2000;108:545–53.

    PubMed  Google Scholar 

  78. Jurisicova A, Taniuchi A, Li H, et al. Maternal Exposure to Polycyclic Aromatic Hydrocarbons Diminishes Murine Ovarian Reserve Via Induction of Harakiri. J Clin Invest 2007;117:3971–8.

    PubMed  CAS  Google Scholar 

  79. Weinberg CR, Wilcox AJ, Baird DD. Reduced Fecundability in Women with Prenatal Exposure to Cigarette Smoking. Am J Epidemiol 1989;129:1072–8.

    PubMed  CAS  Google Scholar 

  80. Arbuckle TE, Lin Z, Mery LS. An Exploratory Analysis of the Effect of Pesticide Exposure on the Risk of Spontaneous Abortion in An Ontario Farm Population. Environ Health Perspect 2001;109:851–7.

    PubMed  CAS  Google Scholar 

  81. Bell EM, Hertz-Picciotto I, Beaumont JJ. A Case-Control Study of Pesticides and Fetal Death Due to Congenital Anomalies. Epidemiology 2001;12:148–56.

    PubMed  CAS  Google Scholar 

  82. Goulet L, Thériault G. Stillbirth and Chemical Exposure of Pregnant Workers. Scand J Work Environ Health 1991;17: 25–31.

    PubMed  CAS  Google Scholar 

  83. Hemminki K, Niemi ML, Saloniemi I, Vainio H, Hemminki E. Spontaneous Abortions by Occupation and Social Class in Finland. Int J Epidemiol 1980;9:149–53.

    PubMed  CAS  Google Scholar 

  84. Pastore LM, Hertz-Picciotto I, Beaumont JJ. Risk of Stillbirth from Occupational and Residential Exposures. Occup Environ Med 1997;54:511–8.

    PubMed  CAS  Google Scholar 

  85. Restrepo M, Muñoz N, Day NE, Parra JE, de Romero L, Nguyen-Dinh X. Prevalence of Adverse Reproductive Outcomes in a Population Occupationally Exposed to Pesticides in Colombia. Scand J Work Environ Health 1990;16:232–8.

    PubMed  CAS  Google Scholar 

  86. Taha TE, Gray RH. Agricultural Pesticide Exposure and Perinatal Mortality in Central Sudan. Bull World Health Organ 1993;71:317–21.

    PubMed  CAS  Google Scholar 

  87. Thomas DC, Petitti DB, Goldhaber M, Swan SH, Rappaport EB, Hertz-Picciotto I. Reproductive Outcomes in Relation to Malathion Spraying in the San Francisco Bay Area, 1981–1982. Epidemiology 1992;3(1):32–9.

    PubMed  CAS  Google Scholar 

  88. Willis WO, de Peyster A, Molgaard CA, Walker C, MacKendrick T. Pregnancy Outcome Among Women Exposed to Pesticides Through Work Or Residence in an Agricultural Area. J Occup Med 1993;35:943–9.

    PubMed  CAS  Google Scholar 

  89. Zhu JL, Hjollund NH, Andersen AM, Olsen J. Occupational Exposure to Pesticides and Pregnancy Outcomes in Gardeners and Farmers: A Study Within the Danish National Birth Cohort. J Occup Environ Med 2006;48:347–52.

    PubMed  Google Scholar 

  90. Greenlee AR, Arbuckle TE, Chyou PH. Risk Factors for Female Infertility in An Agricultural Region. Epidemiology 2003;14:429–36.

    PubMed  Google Scholar 

  91. Greenlee AR, Ellis TM, Berg RL. Low-Dose Agrochemicals and Lawn-Care Pesticides Induce Developmental Toxicity in Murine Preimplantation Embryos. Environ Health Perspect 2004;112:703–9.

    PubMed  CAS  Google Scholar 

  92. Perreault SD, Jeffay SC, Poss P, Laskey JW. Use of the Fungicide Carbendazim as a Model Compound to Determine the Impact of Acute Chemical Exposure During Oocyte Maturation and Fertilization on Pregnancy Outcome in the Hamster. Toxicol Appl Pharmacol 1992;114:225–31.

    PubMed  CAS  Google Scholar 

  93. Zuelke KA, Perreault SD. Carbendazim (MBC) Disrupts Oocyte Spindle FUnction and Induces Aneuploidy in Hamsters Exposed During Fertilization (Meiosis II). Mol Reprod Dev 1995;42:200–9.

    PubMed  CAS  Google Scholar 

  94. Jeffay SC, Libbus BL, Barbee RR, Perreault SD. Acute Exposure of Female Hamsters to Carbendazim (MBC) During Meiosis Results in Aneuploid Oocytes with Subsequent Arrest of Embryonic Cleavage and Implantation. Reprod Toxicol 1996;10:183–9.

    PubMed  CAS  Google Scholar 

  95. Can A, Albertini DF. Stage Specific Effects of Carbendazim (MBC) on Meiotic Cell Cycle Progression in Mouse Oocytes. Mol Reprod Dev 1997;46:351–62.

    PubMed  CAS  Google Scholar 

  96. Czeizel AE, Elek C, Gundy S, et al. Environmental Trichlorfon and Cluster of Congenital Abnormalities. The Lancet 1993;341:539–42.

    CAS  Google Scholar 

  97. Yin H, Cukurcam S, Betzendahl I, Adler ID, Eichenlaub-Ritter U. Trichlorfon Exposure, Spindle Aberrations and Nondisjunction in Mammalian Oocytes. Chromosoma 1998;107:514–22.

    PubMed  CAS  Google Scholar 

  98. Laville N, Balaguer P, Brion F, et al. Modulation of Aromatase Activity and mRNA by Various Selected Pesticides in the Human Choriocarcinoma JEG-3 cell line. Toxicology 2006;228:98–108.

    PubMed  CAS  Google Scholar 

  99. Fuyata ea. Embryotoxic Effects of Methylmercuric Chloride Administered to Mice and Rats During Organogenesisis. Teratology 1978;18:353–66.

    Google Scholar 

  100. Sharara F, Seifer D, Flaws J. Environmental Toxicants and Female Reproduction. Fertil Steril 1998;70:613–22.

    PubMed  CAS  Google Scholar 

  101. Skakkebaek N, Giwercman A, de Kretser D. Pathogenesis and Management of Male Infertility. The Lancet 1994;343: 1473–79.

    CAS  Google Scholar 

  102. Rowland A, Baird D, Weinberg C, Shore D, Shy C, Wilcox A. The Effect of Occupational Exposure to Mercury Vapour on the Fertility of Female Dental Assistants. Occup Environ Med 1994;51:28–34.

    PubMed  CAS  Google Scholar 

  103. Choy C, Lam C, Cheung L, Briton-Jone C, Cheung L, Haines C. Infertility, Blood Mercury Concentrations and Dietary Seafood Consumption: A Case-Control Study. Br J Obstet Gynecol 2002;109:1121–25.

    CAS  Google Scholar 

  104. Mahaffey KR. Recent Advances in Recognition of Low-Level Methylmercury Poisoning. Curr Opin Neurol 2000;13:699–707.

    PubMed  CAS  Google Scholar 

  105. Crump KS, Kjellström T, Shipp AM, Silvers A, Stewart A. Influence of Prenatal Mercury Exposure Upon Scholastic and Psychological Test Performance: Benchmark Analysis of a New Zealand Cohort. Risk Analysis 1998;18: 701–13.

    PubMed  CAS  Google Scholar 

  106. Grandjean P, Weihe P, Burse VW, et al. Neurobehavioral Deficits Associated with PCB in 7-Year-Old Children Prenatally Exposed to Seafood Neurotoxicants. Neurotoxicol Teratol 2001;23:305–17.

    PubMed  CAS  Google Scholar 

  107. Grandjean P, Weihe P, White RF, et al. Cognitive Deficit in 7-Year-Old Children with Prenatal Exposure to Methylmercury. Neurotoxicol Teratol 1997;19:417–28.

    PubMed  CAS  Google Scholar 

  108. Muckle G, Ayotte P, Dewailly E, Jacobson SW, Jacobson JL. Determinants of Polychlorinated Biphenyls and Methylmercury Exposure in Inuit Women of Childbearing Age. Environ Health Perspect 2001;109:957–63.

    PubMed  CAS  Google Scholar 

  109. Hightower JM, O’Hare A, Hernandez GT. Blood Mercury Reporting in NHANES: Identifying Asian, Pacific Islander, Native American, and Multiracial Groups. Environ Health Perspect 2006;114:173–5.

    PubMed  CAS  Google Scholar 

  110. Mahaffey K, Clickner R, Bodurow C. Blood Organic Mercury and Dietary Mercury Intake: National Health and Nutrition Examination Survey, 1999 and 2000. Environ Health Perspect 2004;112:562–70.

    PubMed  CAS  Google Scholar 

  111. Durgnat JM, Heuser J, Andrey D, Perrin C. Quality and Safety Assessment of Ginseng Extracts by Determination of the Contents of Pesticides and Metals. Food Addit Contam 2005;22:1224–30.

    PubMed  CAS  Google Scholar 

  112. Ernst E. Toxic Heavy Metals and Undeclared Drugs in Asian Herbal Medicines. Trends Pharmacol Sci 2002;23: 136–9.

    PubMed  CAS  Google Scholar 

  113. Garvey GJ, Hahn G, Lee RV, Harbison RD. Heavy Metal Hazards of Asian TRaditional Remedies. Int J Environ Health Res 2001;11:63–71.

    PubMed  CAS  Google Scholar 

  114. Saper RB, Kales SN, Paquin J, et al. Heavy Metal Content of Ayurvedic Herbal Medicine Products. JAMA 2004;292: 2868–73.

    PubMed  CAS  Google Scholar 

  115. Geraldine M, Herman DS, Venkatesh T. Lead Poisoning as a Result of Infertility TReatment Using Herbal Remedies. Arch Gynecol Obstet 2007;275:279–81.

    PubMed  Google Scholar 

  116. Al-Saleh I, Coskun S, Mashhour A, et al. Exposure to Heavy Metals (Lead, Cadmium and Mercury) and Its Effect on the Outcome of In-Vitro Fertilization Treatment. Int J Hyg Environ Health 2007;211:560–79.

    PubMed  Google Scholar 

  117. Silberstein T, Saphier O, Paz-Tal O, Gonzalez L, Keefe DL, Trimarchi JR. Trace Element Concentrations in Follicular Fluid of Small Follicles Differ from Those in Blood Serum, and may represent long-term exposure. Fertil Steril 2008; April 17 [Epub ahead of print].

    Google Scholar 

  118. Zenzes MT, Krishnan S, Krishnan B, Zhang H, Casper RF. Cadmium Accumulation in Follicular Fluid of Women in In Vitro Fertilization-Embryo Transfer Is Higher In Smokers. Fertil Steril 1995;64:599–603.

    PubMed  CAS  Google Scholar 

  119. De SK, Paria BC, Dey SK, Andrews GK. Stage-Specific Effects of Cadmium on Preimplantation Embryo Development and Implantation in the Mouse. Toxicology 1993;80: 13–25.

    PubMed  CAS  Google Scholar 

  120. Fernandez EL, Gustafson A-L, Andersson M, Hellman B, Dencker L. Cadmium-Induced Changes in Apoptotic Gene Expression Levels and DNA Damage in Mouse Embryos Are Blocked by Zinc. Toxicol Sci 2003;76:162–70.

    PubMed  CAS  Google Scholar 

  121. Liu L, Trimarchi JR, Navarro P, Blasco MA, Keefe DL. Oxidative Stress Contributes to Arsenic-induced Telomere Attrition, Chromosome Instability, and Apoptosis. J Biol Chem 2003;278:31998–2004.

    PubMed  CAS  Google Scholar 

  122. Navarro PAAS, Liu L, Keefe DL. In Vivo Effects of Arsenite on Meiosis, Preimplantation Development, and Apoptosis in the Mouse. Biol Reprod 2004;70:980–5.

    PubMed  CAS  Google Scholar 

  123. Paksy K, Forgács Z, Gáti I. In VitroComparative Effect of Cd2+, Ni2+, and Co2+ on Mouse Postblastocyst Development. Env Res 1999;80:340–7.

    CAS  Google Scholar 

  124. vom Saal FS, Akingbemi BT, Belcher SM, et al. Chapel Hill Bisphenol A Expert Panel Consensus Statement: Integration of Mechanisms, Effects in Animals and Potential to Impact Human Health at Current Levels of Exposure. Reprod Toxicol 2007;24:131–8.

    PubMed  CAS  Google Scholar 

  125. Welshons WV, Nagel SC, vom Saal FS. Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisphenol A at Levels of Human Exposure. Endocrinology 2006;147:s56–69.

    PubMed  CAS  Google Scholar 

  126. Ikezuki Y, Tsutsumi O, Takai Y, Kamei Y, Taketani Y. Determination of Bisphenol A Concentrations in Human Biological Fluids Reveals Significant Early Prenatal Exposure. Hum Reprod 2002;17:2839–41.

    PubMed  CAS  Google Scholar 

  127. Takeuchi T, Tsutsumi O. Serum Bisphenol A Concentrations Showed Gender Differences, Possibly Linked to Androgen Levels. Biochemical and Biophysical Research Commu­nications 2002;291:76–8.

    CAS  Google Scholar 

  128. Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Ekong J, Needham LL. Urinary Concentrations of Bisphenol A and 4-Nonylphenol in a Human Reference Population. Environ Health Perspect 2005;113:391–5.

    PubMed  CAS  Google Scholar 

  129. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. Exposure of the U.S. Population to Bisphenol A and 4-Tertiary-Octylphenol: 2003–2004. Environ Health Perspect 2008;116:39–44.

    PubMed  CAS  Google Scholar 

  130. Goodman JE, McConnell EE, Sipes IG, et al. An Updated Weight of the Evidence Evaluation of Reproductive and Developmental Effects of Low Doses of Bisphenol A. Crit Rev Toxicol 2006;36:387–457.

    PubMed  CAS  Google Scholar 

  131. vom Saal FS, Welshons WV. Large Effects from Small Exposures. II. The Importance of Positive Controls in Low-Dose Research on Bisphenol A. Environ Res 2006; 100:50–76.

    PubMed  CAS  Google Scholar 

  132. Takai Y, Tsutsumi O, Ikezuki Y, et al. Estrogen Receptor-Mediated Effects of a Xenoestrogen, Bisphenol A, on Preimplantation Mouse Embryos. Biochem Biophys Res Commn 2000;270:918–21.

    CAS  Google Scholar 

  133. Nakagomi M, Suzuki E, Usumi K, et al. Effects of Endocrine Disrupting Chemicals on the Microtubule Network In Chinese Hamster V79 Cells in Culture and in Sertoli cells in Rats. Teratog Carcinog Mutagen 2001; 21:453–62.

    PubMed  Google Scholar 

  134. Pfeiffer E, Rosenberg B, Deuschel S, Metzler M. Interference with Microtubules and Induction of Micronuclei In Vitro By Various Bisphenols. Mutat Res 1997;390:21–31.

    PubMed  CAS  Google Scholar 

  135. Hunt PA, Koehler KE, Susiarjo M, et al. Bisphenol A Exposure Causes Meiotic Aneuploidy in the Female Mouse. Curr Biol 2003;13:546–53.

    PubMed  CAS  Google Scholar 

  136. Can A, Semiz O, Cinar O. Bisphenol-A Induces Cell Cycle Delay and Alters Centrosome and Spindle Microtubular Organization in Oocytes During Meiosis. Mol Hum Reprod 2005;11:389–96.

    PubMed  CAS  Google Scholar 

  137. Can A, Semiz O. Diethylstilbestrol (DES)-Induced Cell Cycle Delay and Meiotic Spindle Disruption in Mouse Oocytes During In-Vitro Maturation. Mol Hum Reprod 2000;6:154–62.

    PubMed  CAS  Google Scholar 

  138. Pocar P, Augustin R, Gandolfi F, Fischer B. Toxic Effects of In Vitro Exposure to p-tert-Octylphenol on Bovine Oocyte Maturation and Developmental Competence. Biol Reprod 2003;69:462–8.

    PubMed  CAS  Google Scholar 

  139. Susiarjo M, Hassold TJ, Freeman E, Hunt PA. Bisphenol A Exposure In Utero Disrupts Early Oogenesis in the Mouse. PLoS Genetics 2007;3:e5.

    PubMed  Google Scholar 

  140. Sugiura-Ogasawara M, Ozaki Y, Sonta S-i, Makino T, Suzumori K. Exposure to Bisphenol A Is Associated with Recurrent Miscarriage. Hum Reprod 2005;20:2325–9.

    PubMed  CAS  Google Scholar 

  141. Safe SH. Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment. Crit Rev Toxicol 1994;24:87–149.

    PubMed  CAS  Google Scholar 

  142. McFarland VA, Clarke JU. Environmental Occurrence, Abundance, and Potential Toxicity of Polychlorinated Biphenyl Congeners: Considerations for a Congener-Specific Analysis. Environ Health Perspect 1989;81:225–39.

    PubMed  CAS  Google Scholar 

  143. Reijnders PJH. Reproductive Failure in Common Seals Feeding on Fish From Polluted Coastal Waters. Nature 1986;324:456–7.

    PubMed  CAS  Google Scholar 

  144. Buck GM, Sever LE, Mendola P, Zielezny M, Vena JE. Consumption of Contaminated Sport Fish from Lake Ontario and Time-to-Pregnancy: New York State Angler Cohort. Am J Epidemiol 1997;146:949–54.

    PubMed  CAS  Google Scholar 

  145. Harris SA, Jones JL. Fish Consumption and PCB-Associated Health Risks in Recreational Fishermen on the James River, Virginia. Environ Res 2008;107:254–63.

    PubMed  CAS  Google Scholar 

  146. Anderson HA, Falk C, Hanrahan L, et al Profiles of Great Lakes Critical Pollutants: A Sentinel Analysis of Human Blood and Urine. The Great Lakes Consortium. Environ Health Perspect 1998;106:279–89.

    PubMed  CAS  Google Scholar 

  147. Kearney JP, Cole DC, Ferron LA, Weber J-P. Blood PCB,p,p’-DDE, and Mirex Levels in Great Lakes Fish and Waterfowl Consumers in Two Ontario Communities. Environ Res 1999;80:S138–S49.

    PubMed  CAS  Google Scholar 

  148. Kosatsky T, Przybysz R, Shatenstein B, Weber J-P, Armstrong B. Fish Consumption and Contaminant Exposure among Montreal-Area Sportfishers: Pilot Study. Environ Res 1999;80:S150–8.

    PubMed  CAS  Google Scholar 

  149. Turyk M, Anderson HA, Hanrahan LP, et al. Relationship of Serum Levels of Individual PCB, Dioxin, and Furan Congeners and DDE with Great Lakes Sport-Caught Fish Consumption. Environ Res 2006;100:173–83.

    PubMed  CAS  Google Scholar 

  150. Bloom MS, Buck Louis GM, Schisterman EF, Liu A, Kostyniak PJ. Maternal Serum Polychlorinated Biphenyl Concentrations Across Critical Windows of Human Development. Environ Health Perspect 2007;115:1320–4.

    PubMed  CAS  Google Scholar 

  151. De Felip E, Domenico Ad, Miniero R, Silvestroni L. Polychlorobiphenyls and Other Organochlorine Compounds in Human Follicular Fluid. Chemosphere 2004;54:1445–9.

    PubMed  CAS  Google Scholar 

  152. Jarrell JF, Villeneuve D, Franklin C, et al. Contamination of Human Ovarian Follicular Fluid and Serum by Chlorinated Organic Compounds in Three Canadian Cities. CMAJ 1993;148(8):1321–7.

    PubMed  CAS  Google Scholar 

  153. Pauwels A, Covaci A, Delbeke L, Punjabi U, Schepens PJC. The Relation Between Levels of Selected PCB Congeners in Human Serum and FOllicular Fluid. Chemosphere 1999;39:2433–41.

    PubMed  CAS  Google Scholar 

  154. Trapp M, Baukloh V, Bohnet HG, Heeschen W. Pollutants in Human Follicular Fluid. Fertil Steril 1984;42:146–8.

    PubMed  CAS  Google Scholar 

  155. Younglai EV, Foster WG, Hughes EG, Trim K, Jarrell JF. Levels of Environmental Contaminants in Human Follicular Fluid, Serum, and Seminal Plasma of Couples Undergoing In Vitro Fertilization. Arch Environ Contam Toxicol 2002;43:121–6.

    PubMed  CAS  Google Scholar 

  156. Buck GM, Vena JE, Schisterman EF, et al. Parental Consumption of Contaminated Sport Fish from Lake Ontario and Predicted Fecundability. Epidemiology 2000;11:388–93.

    PubMed  CAS  Google Scholar 

  157. Axmon A, Rylander L, Strömberg U, Hagmar L. Female Fertility in Relation to the Consumption of Fish Contaminated with Persistent Organochlorine Compounds. Scand J Work Environ Health 2002;28:124–32.

    PubMed  CAS  Google Scholar 

  158. Buck GM, Mendola P, Vena JE, et al. Paternal Lake Ontario Fish Consumption and Risk of Conception Delay, New York State Angler Cohort. Environ Res 1999;80:S13–8.

    PubMed  CAS  Google Scholar 

  159. Cordle F, Locke R, Springer J. Risk Assessment in a Federal Regulatory Agency: An Assessment of Risk Associated with the Human Consumption of Some Species of Fish Contaminated with Polychlorinated Biphenyls (PCBs). Environ Health Perspect 1982;45:171–82.

    PubMed  CAS  Google Scholar 

  160. Dar E, Kanarek MS, Anderson HA, Sonzogni WC. Fish Consumption and Reproductive Outcomes in Green Bay, Wisconsin. Environ Res 1992;59:189–201.

    PubMed  CAS  Google Scholar 

  161. Mendola P, Buck GM, Vena JE, Zielezny M, Sever LE. Consumption of PCB-Contaminated Sport Fish and Risk of Spontaneous Fetal Death. Environ Health Perspect 1995;103(5):498–502.

    PubMed  CAS  Google Scholar 

  162. Sugiura-Ogasawara M, Ozaki Y, Sonta S-i, Makino T, Suzumori K. PCBs, Hexachlorobenzene and DDE are Not Associated with Recurrent Miscarriage. Am J Reprod Immunol 2003;50:485–9.

    PubMed  Google Scholar 

  163. Buck G, Tee G, Fitzgerald E, et al. Maternal Fish Consumption and Infant Birth Size and Gestation: New York State Angler Cohort Study. Environ Health 2003;2:7.

    PubMed  Google Scholar 

  164. Rylander L, Strömberg U, Hagmar L. Dietary Intake of Fish Contaminated with Persistent Organochlorine Compounds in Relation to Low Birthweight. Scand J Work Environ Health 1996;22:260–6.

    PubMed  CAS  Google Scholar 

  165. Fries GF. The PBB Episode in Michigan: an Overall Appraisal. Crit Rev Toxicol 1985;16:105–56.

    PubMed  CAS  Google Scholar 

  166. Small CM, Cheslack-Postava K, Terrell M, et al. Risk of Spontaneous Abortion Among Women Exposed to Polybrominated Biphenyls. Environ Res 2007;105:247–55.

    PubMed  CAS  Google Scholar 

  167. Barsotti DA, Marlar RJ, Allen JR. Reproductive Dysfunction in Rhesus Monkeys Exposed to Low Levels of Polychlorinated Biphenyls (Aoroclor 1248). Food Cosmet Toxicol 1976;14: 99–103.

    PubMed  CAS  Google Scholar 

  168. Brezner E, Terkel J, Perry AS. The Effect of Aroclor 1254 (PCB) on the Physiology of Reproduction in the Female Rat-I. Comp Biochem Physiol C 1984;77:65–70.

    PubMed  CAS  Google Scholar 

  169. Jonsson HTJ, Keil JE, Gaddy RG, Loadholt CB, Hennigar GR, Walker EMJ. Prolonged Ingestion of Commercial DDT and PCB; Effects on Progesterone Levels and Reproduction in the Mature Female Rat. Arch Environ Contam Toxicol 1975;3:479–90.

    PubMed  CAS  Google Scholar 

  170. Müller WF, Hobson W, Fuller GB, Knauf W, Coulston F, Korte F. Endocrine Effects of Chlorinated Hydrocarbons in Rhesus Monkeys. Ecotoxicol Environ Saf 1978;2:161–72.

    PubMed  Google Scholar 

  171. Kholkute SD, Dukelow WR. Effects of Polychlorinated Biphenyl (PCB) Mixtures on In Vitro Fertilization in the Mouse. Bull Environ Contam Toxicol 1997;59:531–6.

    PubMed  CAS  Google Scholar 

  172. Kholkute SD, Rodriguez J, Dukelow WR. Reproductive Toxicity of Aroclor-1254: Effects on Oocyte, Spermatozoa, In Vitro Fertilization, and Embryo Development in the Mouse. Reprod Toxicol 1994;8:487–93.

    PubMed  CAS  Google Scholar 

  173. Kholkute SD, Rodriguez J, Dukelow WR. Effects of Polychlorinated Biphenyls (PCBs) on In Vitro Fertilization in the Mouse. Reprod Toxicol 1994;8:69–73.

    PubMed  CAS  Google Scholar 

  174. Pocar P, Perazzoli F, Luciano AM, Gandolfi F. In Vitro reproductive Toxicity of Polychlorinated Biphenyls: Effects on Oocyte Maturation and Developmental Competence in Cattle. Mol Reprod Dev 2001;58:411–6.

    PubMed  CAS  Google Scholar 

  175. Huang A, Lin S, Inglis R, Powell D, Chou K. Pre- and Postnatal Exposure to 3,3′,4,4′-Tetrachlorobiphenyl: II. Effects on the Reproductive Capacity and Fertilizing Ability of Eggs in Female Mice. Arch Environ Contam Toxicol 1998;34:209–14.

    PubMed  CAS  Google Scholar 

  176. Seiler P, Fischer B, Lindenau A, Beier HM. Fertilization and Early Embryology: Effects of Persistent Chlorinated Hydrocarbons on Fertility and Embryonic Development in the Rabbit. Hum Reprod 1994;9:1920–6.

    PubMed  CAS  Google Scholar 

  177. Hennig B, Meerarani P, Slim R, et al. Proinflammatory Properties of Coplanar PCBs: In Vitro and in Vivo Evidence. Toxicol Appl Pharmacol 2002;181:174–83.

    PubMed  CAS  Google Scholar 

  178. Lehmann DW, Levine JF, Law JM. Polychlorinated Biphenyl Exposure Causes Gonadal Atrophy and Oxidative Stress in Corbicula fluminea Clams. Toxicol Pathol 2007;35:356–65.

    PubMed  CAS  Google Scholar 

  179. Murugesan P, Muthusamy T, Balasubramanian K, Arunakaran J. Studies on the Protective Role of Vitamin C and E Against Polychlorinated Biphenyl (Aroclor 1254): Induced Oxidative Damage in Leydig Cells. Free Radic Res 2005;39:1259–72.

    PubMed  CAS  Google Scholar 

  180. Slim R, Toborek M, Robertson LW, Lehmler HJ, Hennig B. Cellular Glutathione Status Modulates Polychlorinated Biphenyl-Induced Stress Response and Apoptosis in Vascular Endothelial Cells. Toxicol Appl Pharmacol 2000;166:36–42.

    PubMed  CAS  Google Scholar 

  181. Gao X, Son D-S, Terranova PF, Rozman KK. Toxic Equivalency Factors of Polychlorinated Dibenzo-p-dioxins in an Ovulation Model: Validation of the Toxic Equivalency Concept for One Aspect of Endocrine Disruption. Toxicol Appl Pharmacol 1999;157:107–16.

    PubMed  CAS  Google Scholar 

  182. Son D-S, Ushinohama K, Gao X, et al. 2,3,7,8- Tetrachlorodibenzo-p-dioxin (TCDD) Blocks Ovulation By a Direct Action on the Ovary Without Alteration of Ovarian Steroidogenesis: LAck of A Direct Effect on Ovarian Granulosa and Thecal-Interstitial Cell Steroidogenesis In Vitro. Reprod Toxicol 1999;13:521–30.

    PubMed  CAS  Google Scholar 

  183. Schmidt JV, Su GH-T, Reddy JK, Simon MC, Bradfield CA. Characterization of a Murine Ahr Null Allele: Involvement of the Ah Receptor in Hepatic Growth and Development. Proc Nat Acad Sci 1996;93:6731–6.

    PubMed  CAS  Google Scholar 

  184. Kietz S, Fischer B. Polychlorinated Biphenyls Affect Gene Expression in the Rabbit Preimplantation Embryo. Mol Reprod Dev 2003;64:251–60.

    PubMed  CAS  Google Scholar 

  185. Kutz FW, Wood PH, Bottimore DP. Organochlorine Pesticides and Polychlorinated Biphenyls in Human Adipose Tissue. Rev Environ Contam Toxicol 1991;120:1–82.

    PubMed  CAS  Google Scholar 

  186. Venkatesan MI, de Leon RP, van Geen A, Luoma SN. Chlorinated Hydrocarbon Pesticides and Poychlorinated Biphenyls in Sediment Cores from San Francisco Bay. Mar Chem 1999;64:85–97.

    CAS  Google Scholar 

  187. James RA, Hertz-Picciotto I, Willman E, Keller JA, Charles MJ. Determinants of Serum Polychlorinated Biphenyls and Organochlorine Pesticides Measured in Women from the Child Health and Development Study Cohort, 1963–1967. Environ Health Perspect 2002;110:617–24.

    PubMed  CAS  Google Scholar 

  188. Murphy R, Harvey C. Residues and Metabolites of Selected Persistent Halogenated Hydrocarbons in BLood Specimens from a General Population Survey. Environ Health Perspect 1985;60:115–20.

    PubMed  CAS  Google Scholar 

  189. Korrick SA, Chen C, Damokosh AI, et al. Association of DDT with Spontaneous Abortion: A Case-Control Study. Ann Epidemiol 2001;11:491–6.

    PubMed  CAS  Google Scholar 

  190. O’Leary JA, Davies JE, Feldman M. Spontaneous Abortion and Human Pesticide Residues of DDT and DDE. Am J Obstet Gynecol 1970;108:1291–2.

    PubMed  Google Scholar 

  191. Longnecker MP, Klebanoff MA, Dunson DB, et al. Maternal Serum Level of the DDT Metabolite DDE in Relation to Fetal Loss in Previous Pregnancies. Environ Res 2005;97:127–33.

    PubMed  CAS  Google Scholar 

  192. Venners SA, Korrick S, Xu X, et al. Preconception Serum DDT and Pregnancy Loss: A Prospective Study Using a Biomarker of Pregnancy. Am J Epidemiol 2005;162: 709–16.

    PubMed  Google Scholar 

  193. Cocco P, Fadda D, Ibba A, et al. Reproductive outcomes in DDT applicators. Environ Res 2005;98:120–6.

    PubMed  CAS  Google Scholar 

  194. Law DCG, Klebanoff MA, Brock JW, Dunson DB, Longnecker MP. Maternal Serum Levels of Polychlorinated Biphenyls and 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and Time to Pregnancy. Am J Epidemiol 2005;162:523–32.

    PubMed  Google Scholar 

  195. Weiss JM, Bauer O, Blüthgen A, et al. Distribution of Persistent Organochlorine Contaminants in Infertile Patients from Tanzania and Germany. J Assist Reprod Genet 2006;23:393–9.

    PubMed  Google Scholar 

  196. Cohn BA, Cirillo PM, Wolff MS, et al. DDT and DDE Exposure in Mothers and Time to Pregnancy in Daughters. The Lancet 2003;361:2205–6.

    CAS  Google Scholar 

  197. Chedrese JP, Falter F. The Diverse Mechanism of Action of Dichlorodiphenyldichloroethylene (DDE) and Metho­xy­chlor in Ovarian Cells In Vitro. Reprod Toxicol 2001; 15:693–8.

    PubMed  CAS  Google Scholar 

  198. Crellin NK, Kang HG, Swan CL, Chedrese PJ. Inhibition of Basal and Stimulated Progesterone Synthesis By Dichlorodiphenyldichloroethylene and Methoxychlor in a Stable Pig Granulosa Cell Line. Reproduction 2001;121: 485–92.

    PubMed  CAS  Google Scholar 

  199. Crellin NK, Rodway MR, Swan CL, Gillio-Meina C, Chedrese PJ. Dichlorodiphenyldichloroethylene Potentiates the Effect of Protein Kinase A Pathway Activators on Progesterone Synthesis in Cultured Porcine Granulosa Cells. Biol Reprod 1999;61:1099–103.

    PubMed  CAS  Google Scholar 

  200. Holloway AC, Petrik JJ, Younglai EV. Influence of Dichlorodiphenylchloroethylene on Vascular Endothelial Growth Factor and Insulin-Like Growth Factor in Human and Rat Ovarian Cells. Reprod Toxicol 2007;24:359–64.

    PubMed  CAS  Google Scholar 

  201. Greenlee AR, Quail CA, Berg RL. Developmental Alterations in Murine Embryos Exposed In Vitro to An Estrogenic Pesticide, o,p’-DDT. Reprod Toxicol 1999; 13:555–65.

    PubMed  Google Scholar 

  202. Greenlee AR, Quail CA, Berg RL. The Antiestrogen ICI 182,780 Abolishes Developmental Injury for Murine Embryos Exposed In Vitro to o,p’-DDT. Reprod Toxicol 2000;14:225–34.

    PubMed  CAS  Google Scholar 

  203. Greenlee AR, Ellis TM, Berg RL, Mercieca MD. Pregnancy Outcomes for Mouse Preimplantation Embryos Exposed In vitro to the Estrogenic Pesticide o,p’-DDT. Reprod Toxicol 2005;20:229–38.

    PubMed  CAS  Google Scholar 

  204. Dowling V, Hoarau PC, Romeo M, et al. Protein Carbonylation and Heat Shock Response in Ruditapes decussatus Following p,p’-dichlorodiphenyldichloroethylene (DDE) Exposure: A Proteomic Approach Reveals that DDE Causes Oxidative Stress. Aquatic Toxicology 2006; 77:11–8.

    PubMed  CAS  Google Scholar 

  205. Pérez-Maldonado IN, Athanasiadou M, Yáñez L, González-Amaro R, Bergman A, Díaz-Barriga F. DDE-Induced Apoptosis in Children Exposed to the DDT Metabolite. Sci Total Environ 2006;370:343–51.

    PubMed  Google Scholar 

  206. Bock KW, Köhle C. Ah Receptor: Dioxin-Mediated Toxic Responses as Hints to Deregulated Physiologic Functions. Biochem Pharmacol 2006;72:393–404.

    PubMed  CAS  Google Scholar 

  207. Needham LL, Gerthoux PM, Patterson DGJ, et al. Serum Dioxin Levels in Seveso, Italy, Population in 1976. Teratog Carcinog Mutagen 1997;17:225–40.

    PubMed  CAS  Google Scholar 

  208. Eskenazi B, Mocarelli P, Warner M, et al. Relationship of Serum TCDD Concentrations and Age At Exposure of Female Residents of Seveso, Italy. Environ Health Perspect 2004;112:22–7.

    PubMed  CAS  Google Scholar 

  209. Heiden TCK, Struble CA, Rise ML, Hessner MJ, Hutz RJ, Carvan Iii MJ. Molecular Targets of 2,3,7, 8-Tetrachlorodibenzo- p-dioxin (TCDD) Within the Zebra­fish Ovary: Insights into TCDD-Induced Endocrine Disruption and Reproductive Toxicity. Reprod Toxicol 2008;25:47–57.

    PubMed  CAS  Google Scholar 

  210. IARC. Polychlorinated Dibenzo-para-dioxins and Poly-chlorinated Dibenzofurans. IARC Monogr Eval Carcinog Risks Hum 1997:69.

    Google Scholar 

  211. Eskenazi B, Mocarelli P, Warner M, et al. Seveso Women’s Health Study: A Study of the Effects of 2,3,7,8-Tetrachlo­rodibenzo- p-dioxin on Reproductive Health. Chemosphere 2000;40: 1247–53.

    PubMed  CAS  Google Scholar 

  212. Rier SE, Martin DC, Bowman RE, Dmowski WP, Becker JL. Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol 1993;21:433–41.

    PubMed  CAS  Google Scholar 

  213. Yang JZ, Agarwal SK, Foster WG. Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Modulates the Pathophysiology of Endometriosis in the Cynomolgus Monkey. Toxicol Sci 2000;56:374–81.

    PubMed  CAS  Google Scholar 

  214. Foster WG. Endocrine Toxicants Including 2,3,7,8- Terachlorodibenzo-p-Dioxin (TCDD) and Dioxin-like Chemicals and Endometriosis: Is There A Link? J Toxicol Environ Health B 2008;11:177–87.

    CAS  Google Scholar 

  215. Heilier J-F, Nackers F, Verougstraete V, Tonglet R, Lison D, Donnez J. Increased Dioxin-Like Compounds in the Serum of Women with Peritoneal Endometriosis and Deep Endometriotic (Adenomyotic) Nodules. Fertil Steril 2005;84:305–12.

    PubMed  CAS  Google Scholar 

  216. Koninckx PR, Braet P, Kennedy SH, Barlow DH. Dioxin Pollution and Endometriosis in Belgium. Hum Reprod 1994;9:1001–2.

    PubMed  CAS  Google Scholar 

  217. Mayani A, Barel S, Soback S, Almagor M. Dioxin Concentrations in Women with Endometriosis. Hum Reprod 1997;12:373–5.

    PubMed  CAS  Google Scholar 

  218. Pauwels A, Schepens PJC, D’Hooghe T, et al. The Risk of Endometriosis and Exposure to Dioxins and Polychlorinated Biphenyls: A Case-Control Study of Infertile Women. Hum Reprod 2001;16:2050–5.

    PubMed  CAS  Google Scholar 

  219. Rier SPD, Foster WGPD. Environmental Dioxins and Endometriosis. Sem Reprod Med 2003;21:145–54.

    CAS  Google Scholar 

  220. Zhao D, Pritts EA, Chao VA, Savouret J-F, Taylor RN. Dioxin Stimulates RANTES Expression in An In-Vitro Model of Endometriosis. Mol Hum Reprod 2002;8: 849–54.

    PubMed  CAS  Google Scholar 

  221. Tsutsumi O, Uechi H, Sone H, et al. Presence of Dioxins in Human Follicular Fluid: Their Possible Stage-Specific Action on the Development of Preimplantation Mouse Embryos. Biochem Biophys Res Commn 1998;250: 498–501.

    CAS  Google Scholar 

  222. Giavini E, Prati M, Vismara C. Embryotoxic Effects of 2,3,7,8 Tetrachlorodibenzo-p-dioxin Administered to Female Rats Before Mating. Environ Res 1983;31:105–10.

    PubMed  CAS  Google Scholar 

  223. Li XL, Johnson DC, Rozman KK. Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Female Rats: Ovulation, Hormonal Regulation, and Possible Mechanism(s). Toxicol Appl Pharmacol 1995;133:321–7.

    PubMed  CAS  Google Scholar 

  224. Yellon SM, Singh D, Garrett TM, Fagoaga OR, Nehlsen-Cannarella SL. Reproductive, Neuroendocrine, and Immune Consequences of Acute Exposure to 2,3,7, 8-Tetrachlorodibenzo-p-Dioxin in the Siberian Hamster. Biol Reprod 2000;63:538–43.

    PubMed  CAS  Google Scholar 

  225. Blankenship AL, Suffia MC, Matsumura F, Walsh KJ, Wiley LM. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Accelerates Differentiation of Murine Preimplantation Embryos In Vitro. Reprod Toxicol 1993;7:255–61.

    PubMed  CAS  Google Scholar 

  226. Wu Q, Ohsako S, Baba T, Miyamoto K, Tohyama C. Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Preimplantation Mouse Embryos. Toxicology 2002; 174:119–29.

    PubMed  Google Scholar 

  227. Wu Q, Ohsako S, Ishimura R, Suzuki JS, Tohyama C. Exposure of Mouse Preimplantation Embryos to 2,3,7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Methy-lation Status of Imprinted Genes H19 and Igf2. Biol Reprod 2004;70:1790–7.

    PubMed  CAS  Google Scholar 

  228. Hutt K, Shi Z, Albertini D, Petroff B. The Environmental Toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin Disrupts Morphogenesis of the Rat Pre-implantation Embryo. BMC Dev Biol 2008;8:1.

    PubMed  Google Scholar 

  229. Guo Y, Hendrickx AG, Overstreet JW, et al. Endocrine Biomarkers of Early Fetal Loss in Cynomolgus Macaques (Macaca fascicularis) Following Exposure to Dioxin. Biol Reprod 1999;60:707–13.

    PubMed  CAS  Google Scholar 

  230. Li B, Liu HY, Dai LJ, Lu JC, Yang ZM, Huang L. The Early Embryo Loss Caused by 2,3,7,8-Tetrachlorodibenzo-p-dioxin May Be Related to the Accumulation of this Compound in the Uterus. Reprod Toxicol 2006;21:301–6.

    PubMed  CAS  Google Scholar 

  231. Moran FM, VandeVoort CA, Overstreet JW, Lasley BL, Conley AJ. Molecular Target of Endocrine Disruption in Human Luteinizing Granulosa Cells by 2,3,7,8-Tetrachlorodibenzo- p-dioxin: Inhibition of Estradiol Secretion Due to Decreased 17Alpha-hydroxylase/17,20-Lyase Cytochrome P450 Expression. Endocrinology 2003;144:467–73.

    PubMed  CAS  Google Scholar 

  232. Abbott BD, Schmid JE, Pitt JA, et al. Adverse Reproductive Outcomes in the Transgenic Ah Receptor-Deficient Mouse. Toxicol Appl Pharmacol 1999;155:62–70.

    PubMed  CAS  Google Scholar 

  233. Benedict JC, Lin T-M, Loeffler IK, Peterson RE, Flaws JA. Physiological Role of the Aryl Hydrocarbon Receptor in Mouse Ovary Development. Toxicol Sci 2000;56:382–8.

    PubMed  CAS  Google Scholar 

  234. Kishi R, Sata F, Yoshioka E, et al. Exploiting Gene-Environment Interaction to Detect Adverse Health Effects of Environmental Chemicals on the Next Generation. Basic Clin Pharmacol Toxicol 2008;102:191–203.

    PubMed  CAS  Google Scholar 

  235. Pocar P, Fischer B, Klonisch T, Hombach-Klonisch S. Molecular Interactions of the Aryl Hydrocarbon Receptor and Its Biological and Toxicological Relevance for Reproduction. Reproduction 2005;129:379–89.

    PubMed  CAS  Google Scholar 

  236. Pocar P, Nestler D, Risch M, Fischer B. Apoptosis in Bovine Cumulus-Oocyte Complexes After Exposure to Polychlorinated Biphenyl Mixtures During In Vitro Maturation. Reproduction 2005;130:857–68.

    PubMed  CAS  Google Scholar 

  237. Nebert DW, Brown DD, Towne DW, Eisen HJ. Association of fertility, fitness and longevity with the murine Ah locus among (C57BL/6N) (C3H/HeN) recombinant inbred lines. Biol Reprod 1984;30:363–73.

    PubMed  CAS  Google Scholar 

  238. Pocar P, Augustin R, Fischer B. Constitutive Expression of CYP1A1 in Bovine Cumulus Oocyte-Complexes in Vitro: Mechanisms and Biological Implications. Endocrinology 2004;145:1594–601.

    PubMed  CAS  Google Scholar 

  239. Raffensperger C, Tickner J, Schettler T, Jordan A. And Can Mean Saying “Yes” to Innovation. Nature 1999;401: 207–8.

    PubMed  CAS  Google Scholar 

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  1. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA, 94115, USA

    Victor Y. Fujimoto, Linda C. Giudice, V.Y. Fujimoto & L.C. Giudice

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  1. Victor Y. Fujimoto
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  2. Linda C. Giudice
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  3. V.Y. Fujimoto
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  4. L.C. Giudice
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    © 2009 Humana Press, a part of Springer Science+Business Media, LLC

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    Fujimoto, V., Giudice, L., Fujimoto, V., Giudice, L. (2009). Environmental Factors Affecting Female Infertility. In: Voorhis, B., Schlegel, P., Racowsky, C., Carrell, D. (eds) Biennial Review of Infertility. Humana Press. https://doi.org/10.1007/978-1-60327-392-3_1

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