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Antithrombotic Therapy in Carotid and Peripheral Intervention

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Antithrombotic Drug Therapy in Cardiovascular Disease

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Peripheral arterial disease is a spectrum of disease processes involving the non-coronary arterial system that is primarily the result of atherothrombosis. Although the field of peripheral intervention is older than coronary intervention, the evolution of this field has lagged behind that of its coronary counterpart. Adjunctive therapies demonstrated to be beneficial in the realm of percutaneous coronary interventions (PCI) have not been as systematically assessed within the peripheral arena. Nevertheless, current opinion rests with the belief that adjunctive antiplatelet and antithrombotic agents improve outcomes for patients undergoing peripheral interventional procedures. Future studies will foster a better understanding of the idiosyncrasies related to peripheral interventions and the optimal utilization of currently available and developing antithrombotic agents in order to further advance this field.

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References

  1. Dotter CT, Judkins MP (1964) Transluminal treatment of arteriosclerotic obstruction. Description of a new technic and a preliminary report of its application. Circulation 30:654–670

    Article  PubMed  CAS  Google Scholar 

  2. Myler R (2005) Coronary and peripheral angioplasty: a historical perspective. In: Topol EJ (ed) Textbook of interventional cardiology, 4th edn. Saunders, Philadelphia, PA, pp 141–157

    Google Scholar 

  3. Mc LJ (1959) The discovery of heparin. Circulation 19(1):75–78

    Article  Google Scholar 

  4. Gruntzig A (1978) Transluminal dilatation of coronary-artery stenosis. Lancet 1:263

    Article  PubMed  CAS  Google Scholar 

  5. Grayburn PA, Willard JE, Brickner ME et al (1991) In vivo thrombus formation on a guidewire during intravascular ultrasound imaging: evidence for inadequate heparinization. Cathet Cardiovasc Diagn 23(2):141–143

    Article  PubMed  CAS  Google Scholar 

  6. Laskey MA, Deutsch E, Barnathan E et al (1990) Influence of heparin therapy on percutaneous transluminal coronary angioplasty outcome in unstable angina pectoris. Am J Cardiol 65(22):1425–1429

    Article  PubMed  CAS  Google Scholar 

  7. Ahmed I, Majeed A, Powell R (2007) Heparin induced thrombocytopenia: diagnosis and management update. Postgrad Med J 83(983):575–582

    Article  PubMed  CAS  Google Scholar 

  8. Brumberg RS, Back MR, Armstrong PA et al (2007) The relative importance of graft surveillance and warfarin therapy in infrainguinal prosthetic bypass failure. J Vasc Surg 46(6):1160–1166

    Article  PubMed  Google Scholar 

  9. LeCroy CJ, Patterson MA, Taylor SM et al (2005) Effect of warfarin anticoagulation on below-knee polytetrafluoro­ethylene graft patency. Ann Vasc Surg 19(2):192–198

    Article  PubMed  Google Scholar 

  10. Kalra M, Gloviczki P, Andrews JC et al (2003) Open surgical and endovascular treatment of superior vena cava syndrome caused by nonmalignant disease. J Vasc Surg 38(2):215–223

    Article  PubMed  Google Scholar 

  11. Goodman SG, Fitchett D, Armstrong PW et al (2003) Randomized evaluation of the safety and efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide. Circulation 107(2):238–244

    Article  PubMed  CAS  Google Scholar 

  12. (1999) Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. FRagmin and Fast Revascularisation during InStability in Coronary artery disease Investigators. Lancet 354(9180):708–715

    Google Scholar 

  13. Blazing MA, de Lemos JA, White HD et al (2004) Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin: a randomized controlled trial. JAMA 292(1):55–64

    Article  PubMed  CAS  Google Scholar 

  14. Antman EM, McCabe CH, Gurfinkel EP et al (1999) Enoxaparin prevents death and cardiac ischemic events in unstable angina/non-Q-wave myocardial infarction. Results of the thrombolysis in myocardial infarction (TIMI) 11B trial. Circulation 100(15):1593–1601

    Article  PubMed  CAS  Google Scholar 

  15. Cohen M, Demers C, Gurfinkel EP et al (1997) A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group. N Engl J Med 337(7):447–452

    Article  PubMed  CAS  Google Scholar 

  16. Ferguson JJ, Califf RM, Antman EM et al (2004) Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial. JAMA 292(1):45–54

    Article  PubMed  CAS  Google Scholar 

  17. Khosla S, Kunjummen B, Guerrero M et al (2002) Safety and efficacy of combined use of low molecular weight heparin (enoxaparin, lovenox) and glycoprotein IIb/IIIa receptor antagonist (eptifibatide, integrelin) during nonemergent coronary and peripheral vascular intervention. Am J Ther 9(6):488–491

    Article  PubMed  Google Scholar 

  18. Klein W, Buchwald A, Hillis SE et al (1997) Comparison of low-molecular-weight heparin with unfractionated heparin acutely and with placebo for 6 weeks in the management of unstable coronary artery disease. Fragmin in unstable coronary artery disease study (FRIC). Circulation 96(1):61–68

    Article  PubMed  CAS  Google Scholar 

  19. (1999) Long-term low-molecular-mass heparin in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. FRagmin and Fast Revascularisation during InStability in Coronary artery disease. Investigators. Lancet 354(9180):701–707

    Google Scholar 

  20. Mehta SR, Granger CB, Eikelboom JW et al (2007) Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial. J Am Coll Cardiol 50(18):1742–1751

    Article  PubMed  CAS  Google Scholar 

  21. Shammas NW (2005) Complications in peripheral vascular interventions: emerging role of direct thrombin inhibitors. J Vasc Interv Radiol 16(2 Pt 1):165–171

    Article  PubMed  Google Scholar 

  22. Allie DE, Hall P, Shammas NW et al (2004) The Angiomax Peripheral Procedure Registry of Vascular Events Trial (APPROVE): in-hospital and 30-day results. J Invasive Cardiol 16(11):651–656

    PubMed  Google Scholar 

  23. Lincoff AM, Bittl JA, Kleiman NS et al (2004) Comparison of bivalirudin versus heparin during percutaneous coronary intervention (the Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events [REPLACE]-1 trial). Am J Cardiol 93(9):1092–1096

    Article  PubMed  CAS  Google Scholar 

  24. Lincoff AM, Kleiman NS, Kereiakes DJ et al (2004) Long-term efficacy of bivalirudin and provisional glycoprotein IIb/IIIa blockade vs heparin and planned glycoprotein IIb/IIIa blockade during percutaneous coronary revascularization: REPLACE-2 randomized trial. JAMA 292(6):696–703

    Article  PubMed  CAS  Google Scholar 

  25. HORIZONS AMI (2008) http://www.cardiosource.com/img/horizonsami01.ppt. Accessed 23 Feb 2008

  26. Shammas NW, Lemke JH, Dippel EJ et al (2003) Bivalirudin in peripheral vascular interventions: a single center experience. J Invasive Cardiol 15(7):401–404

    PubMed  Google Scholar 

  27. Shammas NW, Lemke JH, Dippel EJ et al (2003) In-hospital complications of peripheral vascular interventions using unfractionated heparin as the primary anticoagulant. J Invasive Cardiol 15(5):242–246

    PubMed  Google Scholar 

  28. Grubbs G (2003) Single center experience with bivalirudin anticoagulation in peripheral vascular interventions: possible benefits over unfractionated heparin. Poster presented at: Cardiovascular Revascularization Therapy Conference, Washington, DC, 26–29 Jan, 2003

    Google Scholar 

  29. Knopf W, St. Joseph’s Hospital experience (2003) Direct thrombin inhibitors in ACS and PCI: the case for bivalirudin replacing unfractionated heparin in PCI. Paper presented at Transcatheter Cardiovascular Therapeutics 14th Annual Scientific Symposium, Washington, DC, 24–28 Sept, 2003

    Google Scholar 

  30. Blaisdell FW, Steele M, Allen RE (1978) Management of acute lower extremity arterial ischemia due to embolism and thrombosis. Surgery 84(6):822–834

    PubMed  CAS  Google Scholar 

  31. Ouriel K (2005) Peripheral arterial thrombolysis. In: Yadav J (ed) Manual of peripheral vascular intervention. Lippincott Williams & Wilkins, Philadelphia, PA, pp 56–68

    Google Scholar 

  32. Zoon K (2007) Important drug warning: safety information regarding the use of abbokinase (urokinase). http://www.fda.gov/cder/biologics/ltr/abb012599.htm. Accessed 10 Dec 2007

  33. Katzen BT, van Breda A (1981) Low dose streptokinase in the treatment of arterial occlusions. AJR Am J Roentgenol 136(6):1171–1178

    PubMed  CAS  Google Scholar 

  34. Lammer J, Pilger E, Justich E et al (1985) Fibrinolysis in chronic arteriosclerotic occlusions: intrathrombotic injections of streptokinase. Work in progress. Radiology 157(1):45–50

    PubMed  CAS  Google Scholar 

  35. Lammer J, Pilger E, Neumayer K et al (1986) Intraarterial fibrinolysis: long-term results. Radiology 161(1):159–163

    PubMed  CAS  Google Scholar 

  36. (1998) Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group.Lancet 2(8607):349–360

    Google Scholar 

  37. (1986) Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto Miocardico (GISSI). Lancet 1(8478):397–402

    Google Scholar 

  38. (1986) A prospective trial of intravenous streptokinase in acute myocardial infarction (I.S.A.M.). Mortality, morbidity, and infarct size at 21 days. The I.S.A.M. Study Group. N Engl J Med 314(23):1465–1471

    Google Scholar 

  39. Totty WG, Gilula LA, McClennan BL et al (1982) Low-dose intravascular fibrinolytic therapy. Radiology 143(1):59–69

    PubMed  CAS  Google Scholar 

  40. (2003) Thrombolysis in the management of lower limb peripheral arterial occlusion – a consensus document. J Vasc Interv Radiol 14(9 Pt 2):S337–S349.

    Google Scholar 

  41. MS SGW, Jones NW et al (1952) Urokinase: an activator of plasma fribinolysin extracted from urine. Am J Physiol 171:768–769

    Google Scholar 

  42. (1973) The urokinase pulmonary embolism trial. A national cooperative study. Circulation 47(2 Suppl):II1–108.

    Google Scholar 

  43. (1974) Urokinase–streptokinase embolism trial. Phase 2 results. A cooperative study. JAMA 229(12):1606–1613

    Google Scholar 

  44. Ouriel K, Kandarpa K, Schuerr DM et al (1999) Prourokinase versus urokinase for recanalization of peripheral occlusions, safety and efficacy: the PURPOSE trial. J Vasc Interv Radiol 10(8):1083–1091

    Article  PubMed  CAS  Google Scholar 

  45. Ouriel K, Veith FJ, Sasahara AA (1998) A comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs. Thrombolysis or Peripheral Arterial Surgery (TOPAS) Investigators. N Engl J Med 338(16):1105–1111

    Article  PubMed  CAS  Google Scholar 

  46. Comerota AJ, Carman TL (2005) Thrombolytic agents and their actions. In: Rutherford R (ed) Vasculary surgery, vol 1, Sixth edth edn. Elsevier Saunders, Philadelphia, PA, pp 530–545

    Google Scholar 

  47. Semba CP, Bakal CW, Calis KA et al (2000) Alteplase as an alternative to urokinase. Advisory Panel on Catheter-Directed Thrombolytic Therapy. J Vasc Interv Radiol 11(3):279–287

    Article  PubMed  CAS  Google Scholar 

  48. Semba CP, Murphy TP, Bakal CW et al (2000) Thrombolytic therapy with use of alteplase (rt-PA) in peripheral arterial occlusive disease: review of the clinical literature. The Advisory Panel. J Vasc Interv Radiol 11(2 Pt 1):149–161

    Article  PubMed  CAS  Google Scholar 

  49. Berridge DC, Gregson RH, Hopkinson BR et al (1991) Randomized trial of intra-arterial recombinant tissue plasminogen activator, intravenous recombinant tissue plasminogen activator and intra-arterial streptokinase in peripheral arterial thrombolysis. Br J Surg 78(8):988–995

    Article  PubMed  CAS  Google Scholar 

  50. Meyerovitz MF, Goldhaber SZ, Reagan K et al (1990) Recombinant tissue-type plasminogen activator versus urokinase in peripheral arterial and graft occlusions: a randomized trial. Radiology 175(1):75–78

    PubMed  CAS  Google Scholar 

  51. Weaver FA, Comerota AJ, Youngblood M et al (1996) Surgical revascularization versus thrombolysis for nonembolic lower extremity native artery occlusions: results of a prospective randomized trial. The STILE Investigators. Surgery versus Thrombolysis for Ischemia of the Lower Extremity. J Vasc Surg 24(4):513–521 (discussion 521–513)

    Article  PubMed  CAS  Google Scholar 

  52. (1994) Results of a prospective randomized trial evaluating surgery versus thrombolysis for ischemia of the lower extremity. The STILE trial. Ann Surg 220(3):251–266; discussion 266–258

    Google Scholar 

  53. Comerota AJ, Weaver FA, Hosking JD et al (1996) Results of a prospective, randomized trial of surgery versus thrombolysis for occluded lower extremity bypass grafts. Am J Surg 172(2):105–112

    Article  PubMed  CAS  Google Scholar 

  54. (2007) Retavase: clinical pharmacology. http://www.rxlist.com/cgi/generic/reteplase_cp.htm. Accessed 31 Dec 2007

  55. Davidian MM, Powell A, Benenati JF et al (2000) Initial results of reteplase in the treatment of acute lower extremity arterial occlusions. J Vasc Interv Radiol 11(3):289–294

    Article  PubMed  CAS  Google Scholar 

  56. Ouriel K, Katzen B, Mewissen M, 7 et al (2000) Reteplase in the treatment of peripheral arterial and venous occlusions: a pilot study. J Vasc Interv Radiol 11:849–854

    Article  PubMed  CAS  Google Scholar 

  57. (1995) Randomised, double-blind comparison of reteplase double-bolus administration with streptokinase in acute myocardial infarction (INJECT): trial to investigate equivalence. International Joint Efficacy Comparison of Thrombolytics. Lancet 346(8971):329–336

    Google Scholar 

  58. Smalling RW, Bode C, Kalbfleisch J et al (1995) More rapid, complete, and stable coronary thrombolysis with bolus administration of reteplase compared with alteplase infusion in acute myocardial infarction. RAPID Investigators. Circulation 91(11):2725–2732

    Article  PubMed  CAS  Google Scholar 

  59. Bode C, Smalling RW, Berg G et al (1996) Randomized comparison of coronary thrombolysis achieved with double-bolus reteplase (recombinant plasminogen activator) and front-loaded, accelerated alteplase (recombinant tissue plasminogen activator) in patients with acute myocardial infarction. The RAPID II Investigators. Circulation 94(5):891–898

    Article  PubMed  CAS  Google Scholar 

  60. (1997) A comparison of reteplase with alteplase for acute myocardial infarction. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO III) Investigators. N Engl J Med 337(16):1118–1123

    Google Scholar 

  61. Burkart DJ, Borsa JJ, Anthony JP et al (2002) Thrombolysis of occluded peripheral arteries and veins with tenecteplase: a pilot study. J Vasc Interv Radiol 13(11):1099–1102

    Article  PubMed  Google Scholar 

  62. Heymans S, Vanderschueren S, Verhaeghe R et al (2000) Outcome and one year follow-up of intra-arterial staphylokinase in 191 patients with peripheral arterial occlusion. Thromb Haemost 83(5):666–671

    PubMed  CAS  Google Scholar 

  63. Hess H, Mietaschk A, Deichsel G (1985) Drug-induced inhibition of platelet function delays progression of peripheral occlusive arterial disease. A prospective double-blind arteriographically controlled trial. Lancet 1(8426):415–419

    Article  PubMed  CAS  Google Scholar 

  64. Clagett GP, Sobel M, Jackson MR et al (2004) Antithrombotic therapy in peripheral arterial occlusive disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126(3 Suppl):609S–626S

    Article  PubMed  CAS  Google Scholar 

  65. (2002) Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324(7329):71–86

    Google Scholar 

  66. Hirsch AT, Haskal ZJ, Hertzer NR et al (2006) ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. Circulation 113(11):e463–e654

    Article  PubMed  Google Scholar 

  67. Davies RF, Goldberg AD, Forman S et al (1997) Asymptomatic Cardiac Ischemia Pilot (ACIP) study two-year follow-up: outcomes of patients randomized to initial strategies of medical therapy versus revascularization. Circulation 95(8):2037–2043

    Article  PubMed  CAS  Google Scholar 

  68. Hueb WA, Bellotti G, de Oliveira SA et al (1995) The Medicine, Angioplasty or Surgery Study (MASS): a prospective, randomized trial of medical therapy, balloon angioplasty or bypass surgery for single proximal left anterior descending artery stenoses. J Am Coll Cardiol 26(7):1600–1605

    Article  PubMed  CAS  Google Scholar 

  69. (1997) Coronary angioplasty versus medical therapy for angina: the second Randomised Intervention Treatment of Angina (RITA-2) trial. RITA-2 trial participants. Lancet 350(9076):461–468

    Google Scholar 

  70. (1996) A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet 348(9038):1329–1339

    Google Scholar 

  71. (2008) CASPAR: Clopidogrel and Acetyl Salicylic Acid in Bypass Surgery for Peripheral ARterial Disease. http://www.clinicaltrials.gov/ct2/show/NCT00174759?term=clopidogrel+and+aspirin&rank=41. Accessed 8 Feb 2008.

  72. (2008) Clopidogrel studied in one of the largest clinical trial programs in the fight against atherothrombosis. http://investor.bms.com/phoenix.zhtml?c=106664&p=irol-newsArticle_print&ID=396544&highlight=. Accessed 8 Feb 2008

  73. Ouriel K (2004) Use of concomitant glycoprotein IIb/IIIa inhibitors with catheter-directed peripheral arterial thrombolysis. J Vasc Interv Radiol 15(6):543–546

    Article  PubMed  Google Scholar 

  74. Duda SH, Tepe G, Luz O et al (2001) Peripheral artery occlusion: treatment with abciximab plus urokinase versus with urokinase alone – a randomized pilot trial (the PROMPT Study). Platelet Receptor Antibodies in Order to Manage Peripheral Artery Thrombosis. Radiology 221(3):689–696

    Article  PubMed  CAS  Google Scholar 

  75. Ouriel K, Castaneda F, McNamara T et al (2004) Reteplase monotherapy and reteplase/abciximab combination therapy in peripheral arterial occlusive disease: results from the RELAX trial. J Vasc Interv Radiol 15(3):229–238

    Article  PubMed  Google Scholar 

  76. Tepe G, Schott U, Erley CM et al (1999) Platelet glycoprotein IIb/IIIa receptor antagonist used in conjunction with thrombolysis for peripheral arterial thrombosis. AJR Am J Roentgenol 172(5):1343–1346

    PubMed  CAS  Google Scholar 

  77. Drescher P, Crain MR, Rilling WS (2002) Initial experience with the combination of reteplase and abciximab for thrombolytic therapy in peripheral arterial occlusive disease: a pilot study. J Vasc Interv Radiol 13(1):37–43

    Article  PubMed  Google Scholar 

  78. Fogarty TJ, Cranley JJ, Krause RJ et al (1963) A method for extraction of arterial emboli and thrombi. Surg Gynecol Obstet. 116:241–244

    PubMed  CAS  Google Scholar 

  79. Kasirajan K, Haskal ZJ, Ouriel K (2001) The use of mechanical thrombectomy devices in the management of acute peripheral arterial occlusive disease. J Vasc Interv Radiol 12(4):405–411

    Article  PubMed  CAS  Google Scholar 

  80. Bates ER, Babb JD, Casey DE et al (2007) ACCF/SCAI/SVMB/SIR/ASITN 2007 clinical expert consensus document on carotid stenting: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (ACCF/SCAI/SVMB/SIR/ASITN Clinical Expert Consensus Document Committee on Carotid Stenting). J Am Coll Cardiol 49(1):126–170

    Article  PubMed  Google Scholar 

  81. (2008) Heart Disease and Stroke Statistics; 2008 update. http://www.americanheart.org/downloadable/heart/1200078608862HS_Stats%202008.final.pdf. Accessed 23 Feb 2008.

  82. (1991) North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 325(7):445–453

    Google Scholar 

  83. (1997) The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet 349(9065):1569

    Google Scholar 

  84. Chimowitz MI, Kokkinos J, Strong J et al (1995) The Warfarin-Aspirin Symptomatic Intracranial Disease Study. Neurology 45(8):1488–1493

    Article  PubMed  CAS  Google Scholar 

  85. Mohr JP, Thompson JL, Lazar RM et al (2001) A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med 345(20):1444–1451

    Article  PubMed  CAS  Google Scholar 

  86. Lewis SC, Sandercock PA (2002) Warfarin or aspirin for recurrent ischemic stroke. N Engl J Med 346(15):1169–1171

    Article  PubMed  Google Scholar 

  87. Anand S, Yusuf S, Xie C et al (2007) Oral anticoagulant and antiplatelet therapy and peripheral arterial disease. N Engl J Med 357(3):217–227

    Article  PubMed  CAS  Google Scholar 

  88. Bush RL, Lin PH, Mureebe L et al (2005) Routine bivalirudin use in percutaneous carotid interventions. J Endovasc Ther 12(4):521–522

    Article  PubMed  Google Scholar 

  89. Finks SW (2006) Bivalirudin use in carotid endarterectomy in a patient with heparin-induced thrombocytopenia. Ann Pharmacother 40(2):340–343

    Article  PubMed  Google Scholar 

  90. (1995) Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 333(24):1581–1587

    Google Scholar 

  91. Furlan A, Higashida R, Wechsler L et al (1999) Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 282(21):2003–2011

    Article  PubMed  CAS  Google Scholar 

  92. Lewandowski CA, Frankel M, Tomsick TA et al (1999) Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke 30(12):2598–2605

    Article  PubMed  CAS  Google Scholar 

  93. (2004) Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke 35(4):904–911

    Google Scholar 

  94. (2008) Interventional management of stroke – III. http://www.strokecenter.org/trials/TrialDetail.aspx?tid=747. Accessed 8 Feb 2008.

  95. Bellavance A (1993) Efficacy of ticlopidine and aspirin for prevention of reversible cerebrovascular ischemic events. The Ticlopidine Aspirin Stroke Study. Stroke 24(10):1452–1457

    Article  PubMed  CAS  Google Scholar 

  96. Diener HC, Bogousslavsky J, Brass LM et al (2004) Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 364(9431):331–337

    Article  PubMed  CAS  Google Scholar 

  97. Adams HP Jr, Effron MB, Torner J et al (2008) Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II). Stroke 39(1):87–99

    Article  PubMed  CAS  Google Scholar 

  98. Chan AW, Yadav JS, Bhatt DL et al (2005) Comparison of the safety and efficacy of emboli prevention devices versus platelet glycoprotein IIb/IIIa inhibition during carotid stenting. Am J Cardiol 95(6):791–795

    Article  PubMed  CAS  Google Scholar 

  99. Kapadia SR, Bajzer CT, Ziada KM et al (2001) Initial experience of platelet glycoprotein IIb/IIIa inhibition with abciximab during carotid stenting: a safe and effective adjunctive therapy. Stroke 32(10):2328–2332

    Article  PubMed  CAS  Google Scholar 

  100. (2008) ReoPro Retavase Reperfusion of Stroke Safety Study – Imaging Evaluation. http://www.strokecenter.org/trials/TrialDetail.aspx?tid=462. Accessed 8 Feb 2008

  101. (2008) Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke. http://www.strokecenter.org/trials/TrialDetail.aspx?tid=478. Accessed 8 Feb 2008

  102. Smith WS, Sung G, Starkman S et al (2005) Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 36(7):1432–1438

    Article  PubMed  Google Scholar 

  103. Stringer KA, Lindenfeld J (1992) Hirudins: antithrombin anticoagulants. Ann Pharmacother 26(12):1535–1540

    PubMed  CAS  Google Scholar 

  104. Rajan DK, Patel NH, Valji K et al (2005) Quality improvement guidelines for percutaneous management of acute limb ischemia. J Vasc Interv Radiol 16(5):585–595

    Article  PubMed  Google Scholar 

  105. Pilger E, Lammer J, Bertuch H et al (1986) Intraarterial fibrinolysis: in vitro and prospective clinical evaluation of three thrombolytic agents. Radiology 161(3):597–599

    PubMed  CAS  Google Scholar 

  106. Arepally A, Hofmann LV, Kim HS et al (2002) Weight-based rt-PA thrombolysis protocol for acute native arterial and bypass graft occlusions. J Vasc Interv Radiol 13(1):45–50

    Article  PubMed  Google Scholar 

  107. Tepe G, Hopfenzitz C, Dietz K et al (2006) Peripheral arteries: treatment with antibodies of platelet receptors and reteplase for thrombolysis – APART trial. Radiology 239(3):892–900

    Article  PubMed  Google Scholar 

  108. Burkart DJ, Borsa JJ, Anthony JP et al (2003) Thrombolysis of acute peripheral arterial and venous occlusions with tenecteplase and eptifibatide: a pilot study. J Vasc Interv Radiol 14(6):729–733

    Article  PubMed  Google Scholar 

  109. Kapadia SR, Ramee S (2005) Percutaneous mechanical thrombectomy for arterial thrombus. In: Yadav J (ed) Manual of peripheral vascular intervention. Lippincott Williams & Wilkins, Philadelphia, PA, pp 69–82

    Google Scholar 

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA

    Thomas J. Helton MD & Samir R. Kapadia MD

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  1. Thomas J. Helton MD
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  2. Samir R. Kapadia MD
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Editors and Affiliations

  1. Western Reserve Heart Care, Corporate Dr. 1335, Hudson, 44236, U.S.A.

    Arman T. Askari

  2. Dept. Cardiovascular Medicine, Cleveland Clinic, Euclid Ave. 9500, Cleveland, 44195, U.S.A.

    A. Michael Lincoff

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Helton, T.J., Kapadia, S.R. (2010). Antithrombotic Therapy in Carotid and Peripheral Intervention. In: Askari, A., Lincoff, A. (eds) Antithrombotic Drug Therapy in Cardiovascular Disease. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-235-3_15

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