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Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems pp 231–244Cite as

Cell Cycle Regulation in Myogenesis

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Abstract

Skeletal myoblasts differentiation begins with irreversible withdrawal of myoblasts from the cell cycle. This growth arrest is mediated and maintained by the Rb protein, together with p21 and other inhibitors of cell cycle progression. The subsequent activation of muscle-specific promoters at the onset of differentiation is regulated by myogenic bHLH transcription factors, such as MyoD. MyoD protein binds DNA and recruits coactivators and corepressors of transcription to specific promoters and orchestrates the early differentiation events that lead to the fusion of myoblasts into myotubes and the formation of skeletal muscle.

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Authors and Affiliations

  1. Department of Histology and Medical Embryology, University “La Sapienza”, Rome, Italy

    Cristina Giacinti & Antonio Giordano M.D.

  2. Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA

    Antonio Giordano M.D.

  3. Department of Human Pathology and Oncology, University of Siena, Siena, Italy

    Antonio Giordano M.D.

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  1. Cristina Giacinti
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  2. Antonio Giordano M.D.
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Correspondence to Cristina Giacinti .

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  1. College of Science & Technology, Sbarro Institute for Cancer Research, Temple University, N. 12th Street 1900, Philadelphia, 19122, USA

    Antonio Giordano

  2. Dipto. Medicina Sperimentale, Sezione di Biotecnologia e, Università Napoli Federico II, Via Costantinopoli 16, Napoli, 80138, Italy

    Umberto Galderisi

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Giacinti, C., Giordano, A. (2010). Cell Cycle Regulation in Myogenesis. In: Giordano, A., Galderisi, U. (eds) Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems. Springer, New York, NY. https://doi.org/10.1007/978-1-60327-153-0_11

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