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BAFF Receptor Regulation of Peripheral B-Lymphocyte Survival and Development

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Book cover BLyS Ligands and Receptors

Part of the book series: Contemporary Immunology ((CONTIM))

Abstract

B-lymphocyte homeostasis depends on exogenous signals for survival during development and in immune responses to invading pathogens. These signals are continually provided by either tonic or antigen-mediated BCR signals and other trophic factors. B-cell-activating factor (BAFF) has emerged as a key growth factor for B lymphocytes. Through its interaction with a TNF-R family member, BAFF-R or BR3, BAFF promotes survival of both immature and mature B cells. BAFF/BR3 interaction also facilitates BCR-induced B-cell proliferation. Thus, dysregulation of the signals emanating from these receptors leads to autoimmune disease, whereas interference with these signals leads to B-cell immunodeficiencies. Multiple signal transduction pathways, including those involving transcription factor NF-κB, appear to play critical roles in BAFF-mediated B-cell biological responses. Recent studies have revealed that BR3 and BCR are functionally linked and that Bruton’s cytoplasmic tyrosine kinase (Btk)/NF-κB signaling plays an essential role in this process. Therefore, the primary objective of this article is to discuss BR3-signaling pathways, and the cooperation with BCR signals, that regulate B-cell survival during development and activation.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Miami, 33136, Miami, FL, USA

    Wasif N. Khan

  2. Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 37232, Nashville, TN, USA

    Nicholas P. Shinners, Iris Castro & Kristen L. Hoek

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  1. Wasif N. Khan
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  2. Nicholas P. Shinners
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  3. Iris Castro
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  4. Kristen L. Hoek
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Correspondence to Wasif N. Khan .

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  1. School of Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, 19104-6082, U.S.A.

    Michael P. Cancro

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Khan, W.N., Shinners, N.P., Castro, I., Hoek, K.L. (2009). BAFF Receptor Regulation of Peripheral B-Lymphocyte Survival and Development. In: Cancro, M. (eds) BLyS Ligands and Receptors. Contemporary Immunology. Humana Press. https://doi.org/10.1007/978-1-60327-013-7_2

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