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Diabetic Retinopathy pp 265–282Cite as

Capillary Dropout in Diabetic Retinopathy

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Part of the book series: Contemporary Diabetes ((CDI))

Abstract

Capillary dropout is a critical process in diabetic retinopathy, resulting in ischemia, release of angiogenic growth factors, and sight-threatening retinal neovascularization.

It is essential to gain a greater understanding of this process in order to develop improved treatments for diabetic retinopathy. This chapter will review the organization, structure, and cellular composition of retinal capillaries. The histopathologic and clinical manifestations of capillary dropout in diabetic retinopathy will be discussed. Methods for detecting capillary dropout and experimental models for studying this phenomenon will be presented. Potential mechanisms for capillary dropout as well as contributory biochemical pathways will be discussed. Finally, the clinical consequences of capillary dropout will be summarized, highlighting the critical importance of this process in the pathophysiology of diabetic retinopathy.

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Acknowledgments

Authors would like to thank Dr. T. S. Kern and Dr. R. N. Frank for providing the patient pictures included in this chapter and Mamta Kanwar for technical help. The studies from our laboratory reported here were supported in part by research grants from the National Institutes of Health, the Juvenile Diabetes Foundation International, and by a departmental unrestricted grant from Research to Prevent Blindness.

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  1. Kresge Eye Institute, Wayne State University, Detroit, MI

    Renu A. Kowluru & Pooi-See Chan

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  1. Renu A. Kowluru
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  2. Pooi-See Chan
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  1. The Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Elia J. Duh MD

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© 2008 Humana Press, a part of Springer Science + Business Media, LLC

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Kowluru, R.A., Chan, PS. (2008). Capillary Dropout in Diabetic Retinopathy. In: Duh, E.J. (eds) Diabetic Retinopathy. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-59745-563-3_11

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  • DOI: https://doi.org/10.1007/978-1-59745-563-3_11

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