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Age-Related Changes of the Human Eye pp 239–256Cite as

Age-Related Macular Degeneration I: Types and Future Directions

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Part of the book series: Aging Medicine ((AGME))

Abstract

Age-related macular degeneration is the leading cause of severe visual impairment in industrialized countries in patients over 50 years of age. In its natural course, AMD leads to progressive loss of central vision, leaving the patients with only orienting vision and the peripheral visual field at its final stage.

This chapter deals with the description of future trends in therapy. In fact, combination therapies will become more tailored to the stage and severity of the disease. To provide long-term effects, long-acting delivery systems for drug combinations need to be developed. In addition, combinations with surgical therapies, laser, or photodynamic treatment (PDT) might be reasonable to decrease dosage and treatment intervals. For non-responders or advanced cases of AMD, cell-derived therapies will be necessary—like retinal transplantation or gene therapies— for better restoration of a more normal foveal condition to restore the vision in an aging patient.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, The Ludwig Boltzmann Institute for Retinology and Bio-microscopic Laser Surgery, Rudolf Foundation Clinic, Rudolf Foundation Clinic, Vienna, Austria

    Susanne Binder MD & Christiane I. Falkner-Radler MD

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  1. Susanne Binder MD
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  2. Christiane I. Falkner-Radler MD
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Editors and Affiliations

  1. Department of Cardiovascular, Respiratory and Morphological Sciences, University of Rome, La Sapienza, Rome, Italy

    Carlo A. P. Cavallotti MD, PhD

  2. Department of Ophthalmology, University of Rome, Tor Vergata, Rome, Italy

    Luciano Cerulli MD, PhD

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Binder, S., Falkner-Radler, C.I. (2008). Age-Related Macular Degeneration I: Types and Future Directions . In: Cavallotti, C.A.P., Cerulli, L. (eds) Age-Related Changes of the Human Eye. Aging Medicine. Humana Press. https://doi.org/10.1007/978-1-59745-507-7_12

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  • DOI: https://doi.org/10.1007/978-1-59745-507-7_12

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