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The Cannabinoid Receptors pp 153–171Cite as

Cannabinoid Receptor Signal Transduction Pathways

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Part of the book series: The Receptors ((REC))

Abstract

The cannabinoid receptors CB1 and CB2 each couple to intracellular G proteins in order to transduce agonist binding into a cellular response. Signalling by the two receptors can differ markedly, as indeed can signal transduction through each individual receptor in response to various ligands. The divergence of signalling is regulated at various stages—from G protein coupling to activation of effectors, and in many cases appears to be cell type specific. This review will initially examine the ability of CB1 and CB2 to activate G proteins, and then look at downstream pathways, both G protein dependent and independent, that are activated by these receptors.

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  1. Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, New Zealand

    Michelle Glass

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  1. Emma Scotter
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Correspondence to Michelle Glass .

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  1. University of North Carolina, Greensboro, NC, USA

    Patricia H. Reggio

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Scotter, E., Graham, S., Glass, M. (2009). Cannabinoid Receptor Signal Transduction Pathways. In: Reggio, P.H. (eds) The Cannabinoid Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-503-9_6

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