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Clinical Pharmacogenomics

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Molecular Genetic Pathology

Abstract

OME is from Latin-oma meaning “mass.” A genome is defined as the complete DNA sequence of an organism, and genomics (also known as functional genomics) is the comprehensive analysis of genomic structure and function. The development of genomics was greatly facilitated by the Human Genome Project and the publication of the draft sequence of the human genome in 2001. This and the development of several enabling technologies such as automated high-throughput DNA sequencing and genotyping, microarray technology, and bioinformatics now allow for complete views of human biological systems including drug activity. These developments have shifted research from gene discovery to the association of specific genes and genetic variants with disease susceptibility, response to therapy, and other phenotypes of importance in healthcare

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Author information

Authors and Affiliations

  1. Eli Lilly and Company, Indianapolis, IN

    Catalina Lopez-Correa MD, PhD (Principal Research Scientist) & Lawrence M. Gelbert PhD (Research Advisor)

Authors
  1. Catalina Lopez-Correa MD, PhD
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  2. Lawrence M. Gelbert PhD
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Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine and Clarian Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN

    Liang Cheng MD (Professor of Pathology and Urology, Director of Molecular Pathology Laboratory, Chief of Genitourinary Pathology Division) (Professor of Pathology and Urology, Director of Molecular Pathology Laboratory, Chief of Genitourinary Pathology Division)

  2. Department of Pathology, Mount Sinai School of Medicine, New York, NY

    David Y. Zhang MD, PhD, MPH (Associate Professor of Pathology Director, Molecular Pathology Laboratory) (Associate Professor of Pathology Director, Molecular Pathology Laboratory)

  3. Mount Sinai Medical Center, New York, NY

    David Y. Zhang MD, PhD, MPH (Associate Professor of Pathology Director, Molecular Pathology Laboratory) (Associate Professor of Pathology Director, Molecular Pathology Laboratory)

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Lopez-Correa, C., Gelbert, L.M. (2008). Clinical Pharmacogenomics. In: Cheng, L., Zhang, D.Y. (eds) Molecular Genetic Pathology. Humana Press. https://doi.org/10.1007/978-1-59745-405-6_10

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  • DOI: https://doi.org/10.1007/978-1-59745-405-6_10

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-974-1

  • Online ISBN: 978-1-59745-405-6

  • eBook Packages: MedicineMedicine (R0)

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