This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
1. Tilton RG. Capillary pericytes: perspectives and future trends. J Electron Microsc Tech 1991;19:327–344.
2. Hirschi KK and D'Amore PA. Pericytes in the microvasculature. Cardiovasc Res 1996;32:687–698.
3. Kawamura H, Sugiyama T, Wu DM, Kobayashi M, Yamanishi S, Katsumura K, Puro DG. ATP: a vasoactive signal in the pericyte-containing microvasculature of the rat retina. J Physiol 2003;551:787–799.
4. Kawamura H, Kobayashi M, Li Q, Yamanishi S, Katsumura K, Minami M, Wu DM, Puro DG. Effects of angiotensin II on the pericyte-containing microvasculature of the rat retina. J Physiol 2004;561:671–683.
5. Wu DM, Kawamura H, Sakagami K, Kobayashi M, Puro DG. Cholinergic regulation of pericyte-containing retinal microvessels. Am J Physiol 2003;284:H2083–H2090.
6. Yamanishi S, Katsumura K, Kobayashi T, Puro DG. Extracellular lactate as a dynamic vasoactive signal in the rat retinal microvasculature. Am J Physiol 2006;290:H925–H934.
7. Puro DG. Vasoactive signals and pericyte function in the retina. In: Shepro D and D'Amore PA, editors. Microvascular Research: Biology and Pathology. USA: Elsevier; 2006. p. 265–269.
8. Dodge AB, Hechtman HB, Shepro D. Microvascular endothelial-derived autacoids regulate pericyte contractility. Cell Motil Cytoskeleton 1991;18:180–188.
9. Haefliger IO, Zschauer A, Anderson DR. Relaxation of retinal pericyte contractile tone through the nitric oxide-cyclic guanosine monophosphate pathway. Invest Ophthalmol Vis Sci 1994;35:991–997.
10. Kelley C, D'Amore P, Hechtman HB, Shepro D. Microvascular pericyte contractility in vitro: comparison with other cells of the vascular wall. J Cell Biol 1987;104:483–490.
11. Kelley C, D'Amore P, Hechtman HB, Shepro D. Vasoactive hormones and cAMP affect pericyte contraction and stress fibres in vitro. J Muscle Res Cell Motil 1988;9:184–194.
12. Funk RH. Blood supply of the retina. Ophthalmic Res 1997;29:320–325.
13. Ye XD, Laties AM, Stone RA. Peptidergic innervation of the retinal vasculature and optic nerve head. Invest Ophthalmol Vis Sci 1990;31:1731–1737.
14. Shepro D and Morel NM. Pericyte physiology. FASEB J 1993;7:1031–1038.
15. Frank RN, Turczyn TJ, Das A. Pericyte coverage of retinal and cerebral capillaries. Invest Ophthalmol Vis Sci 1990;31:999–1007.
16. Puro DG. Physiology and pathobiology of the pericyte-containing retinal microvasculature: new developments. Microcirculation 2007;14:1–10.
17. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001;414:782–787.
18. Cogan DG, Toussaint D, Kuwabara T. Retinal vascular patterns. IV. Diabetic retinopathy. Arch Ophthalmol 1961;166:366–378.
19. Mizutani M, Kern TS, Lorenzi M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest 1996;97:2883–2890.
20. Kohner EM, Patel V, Rassam SM. Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy. Diabetes 1995;44:603–607.
21. Cunha-Vaz J, Faria de Abreu JR, Campos AJ. Early breakdown of the blood-retinal barrier in diabetes. Br J Ophthalmol 1975;59:649–656.
22. Trick GL and Berkowitz BA. Retinal oxygenation response and retinopathy. Prog Retin Eye Res 2005;24:259–274.
23. Matsushita K and Puro DG. Topographical heterogeneity of KIR currents in pericyte-containing microvessels of the rat retina: effect of diabetes. J Physiol 2006;573:483–495.
24. Sugiyama T, Kobayashi M, Kawamura H, Li Q, Puro DG. Enhancement of P2X7-induced pore formation and apoptosis: an early effect of diabetes on the retinal microvasculature. Invest Ophthalmol Vis Sci 2004;45:1026–1032.
25. Chrissobolis S, and Sobey CG. Inwardly rectifying potassium channels in the regulation of vascular tone. Curr Drug Targets 2003;4:281–289.
26. Zaritsky JJ, Eckman DM, Wellman GC, Nelson MT, Schwarz TL. Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K+ current in K+-mediated vasodilation. Circ Res 2000:87:160–166.
27. Edwards FR, Hirst GD, Silverberg GD. Inward rectification in rat cerebral arterioles; involvement of potassium ions in autoregulation. J Physiol 1988;404:455–466.
28. Oku H, Kodama T, Sakagami K, Puro DG. Diabetes-induced disruption of gap junction pathways within the retinal microvasculature. Invest Ophthalmol Vis Sci 2001;42: 1915–1920.
29. Wu DM, Miniami M, Kawamura H, Puro DG. Electrotonic transmission within pericyte-containing retinal microvessels. Microcirculation 2006;13:353–363.
30. Nicoletti R, Venza I, Ceci G, Visalli M, Teti D, Reibaldi A. Vitreous polyamines spermidine, putrescine, and spermine in human proliferative disorders of the retina. Br J Ophthalmol 2003;87:1038–1042.
31. Grunwald J and Bursell S-E. Hemodyanmic changes as early markers of diabetic retinopathy. Curr Opin Endocrin Diab 1996;3:298–306.
32. North RA. Molecular physiology of P2X receptors. Physiol Rev 2002;82:1013–1067.
33. Sugiyama T, Kawamura H, Yamanishi S, Kobayashi M, Katsumura K, Puro DG. Regulation of P2X7-induced pore formation and cell death in pericyte-containing retinal microvessels. Am J Physiol 2005;288:C568–576.
Liao SD and Puro DG. NAD+-induced vasotoxicity in the pericyte-containing microvasculature of the rat retina: effect of diabetes. Invest Ophthalmol Vis Sci 2006; in press.
The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977–986.
36. Wiederholt M, Berwick S, Helbig H. Electrophysiological properties of cultured retinal capillary pericytes. Prog Retina Eye Res 1995;14:437–451.
37. Quignard JF, Harley EA, Duhault J, Vanhoutte PM, Feletou M. K+ channels in cultured bovine retinal pericytes: effects of beta-adrenergic stimulation. J Cardiovasc Pharmacol 2003;42:379–388.
38. McGinty A, Scholfield CN, Liu WH, Anderson P, Hoey DE, Trimble ER. Effect of glucose on endothelin-1-induced calcium transients in cultured bovine retinal pericytes. J Biol Chem 1999;274:25250–25253.
39. Stitt, A.W., and Curtis, T.M. (2005) Advanced glycation and retinal pathology during diabetes. Pharmacol Rep 2005;57(Suppl):156–168.
40. Hughes SJ, Wall N, Scholfield CN, McGeown JG, Gardiner TA, Stitt AW, Curtis TM. Advanced glycation endproduct modified basement membrane attenuates endothelin-1 induced [Ca2+]i signalling and contraction in retinal microvascular pericytes. Mol Vis 2004;10:996–1004.
41. Antonetti DA, Barber AJ, Khin S, Lieth E, Tarbell JM, Gardner TW. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Diabetes 1998;47:1953–1959.
42. Antonetti DA, Lieth E, Barber AJ, Gardner TW. Molecular mechanisms of vascular permeability in diabetic retinopathy. Semin Ophthalmol 1999;14:240–248.
43. Sakagami K, Wu DM, Puro DG. Physiology of rat retinal pericytes: modulation of ion channel activity by serum-derived molecules. J Physiol 1999;521:637–650.
44. Le Roith D. Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. N Engl J Med 1997;336:633–640.
45. Sakagami K, Kawamura H, Wu DM, Puro DG. Nitric oxide/cGMP-induced inhibition of calcium and chloride currents in retinal pericytes. Microvasc Res 2001;62:196–203.
46. Sakagami K, Kodama T, and Puro DG. PDGF-induced coupling of function with metabolism in microvascular pericytes of the retina. Invest Ophthalmol Vis Sci 2001;42:1939–1944.
47. Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997;277:242–245.
Acknowledgements
National Insitiute of Health grants EY12505, EY07003 and a senior investigator award from Research to Prevent Blindness, Inc. provided support to the author.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Humana Press, a part of Springer Science + Business Media, LLC
About this chapter
Cite this chapter
Puro, D.G. (2008). Pathophysiology of Pericyte-containing Retinal Microvessels. In: Tombran-Tink, J., Barnstable, C.J. (eds) Ocular Transporters In Ophthalmic Diseases And Drug Delivery. Ophthalmology Research. Humana Press. https://doi.org/10.1007/978-1-59745-375-2_7
Download citation
DOI: https://doi.org/10.1007/978-1-59745-375-2_7
Publisher Name: Humana Press
Print ISBN: 978-1-58829-958-1
Online ISBN: 978-1-59745-375-2
eBook Packages: MedicineMedicine (R0)