Key Points
Pulmonary Rehabilitation is an evidence-based, multidisciplinary, and comprehensive intervention for patients with chronic respiratory diseases.
Consequences of COPD include:
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Respiratory limitation
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Reripheral muscle dysfunction
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Respiratory muscle dysfunction
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Cardiac abnormality
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Nutritional abnormality
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Skeletal abnormality
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Psychosocial issue
Recent studies have unraveled mechanistic reasons why pulmonary rehabilitation works.
The components of pulmonary rehabilitation include:
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Assessment/re-assessment
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Exercise training
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Education and self-management strategies
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Nutritional intervention
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Psychological and social consideration
Pulmonary rehabilitation has emerged as an evidence-based science showing its effectiveness across multiple outcome areas. However, pulmonary rehabilitation does not improve forced expiratory volume at 1 s (FEV1).
Pulmonary rehabilitation has now become one of the standard therapies for chronic obstructive pulmonary disease.
The major goals of pulmonary rehabilitation are:
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To reduce burden of symptoms such as dyspnoea and fatigue
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To improve functional status
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To increase participation in physical and social activities
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To improve health related quality of life
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To reduce health care utilization
The following are general criteria for pulmonary rehabilitation referral:
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Severe dyspnoea and/or fatigue
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Decreased exercise ability
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Interference with performing physical activities of daily living
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Impaired health status
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Decreased occupational performance
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Nutritional depletion
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Frequent respiratory exacerbations
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Increased medical resource consumption
Pulmonary rehabilitation should be administered throughout the course of COPD, be an integral part of COPD therapy, and complement pharmacological intervention for COPD.
Pulmonary rehabilitation is still under-utilized due to combination of under-awareness of its effectiveness by health care providers, unavailability of programs in some area, and insufficient third-party reimbursement.
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References
Haas A, Cardon H (1969) Rehabilitation in chronic obstructive lung disease: a 5-year study of 252 male patients. Med Clin North Am 53:593–606
Global Initiative for Chronic Obstructive Pulmonary Disease Workshop Report. http://www.goldcopd.com
ATS-ERS Statement on the Diagnosis and Treatment of COPD www.thoracic.org
Nici L, Donner C, ZuWallack R, Wouters E et al (2006) The ATS/ERS statement on pulmonary rehabilitation. Am J Respir Crit Care Med 173:1390–1414
ACCP-AACVPR Pulmonary Rehabilitation Guidelines Panel (1997) Pulmonary rehabilitation: joint ACCP/AACVPR evidence based guidelines. Chest 112:1363–1396
Decramer M et al (2005) Systemic effects of COPD. Respir Med 99(Suppl B):S3–10
O’Donnell DE (2001) Ventilatory limitations in chronic obstructive pulmonary disease. Med Sci Sports Exerc 33(7 Suppl):S647–55
Rodrigues F (2004) Limiting factors of exercise capacity in patients with COPD. Rev Port Pneumol 10(1):9–61
Puente-Maestu L et al (2005) Dyspnea, ventilatory pattern, and changes in dynamic hyperinflation related to the intensity of constant work rate exercise in COPD. Chest 128(2):651–6
Bianchi R et al (2004) Chest wall kinematics and breathlessness during pursed-lip breathing in patients with COPD. Chest 125(2):459–65
Kobayashi S et al (1996) Relationship between breathlessness and hypoxic and hypercapnic ventilatory response in patients with COPD. Eur Respir J 9(11):2340–5
Somfay A et al (2002) Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in nonhypoxemic COPD patients. Chest 121(2):393–400
Bee D, Howard P (1993) The carotid body: a review of its anatomy, physiology and clinical importance. Monaldi Arch Chest Dis 48(1):48–53
Mador MJ, Bozkanat E (2001) Skeletal muscle dysfunction in chronic obstructive pulmonary disease. Respir Res 2(4):216–24
Maltais F et al (2000) Oxidative enzyme activities of the vastus lateralis muscle and the functional status in patients with COPD. Thorax 55(10):848–53
Franssen FM et al (2005) Limb muscle dysfunction in COPD: effects of muscle wasting and exercise training. Med Sci Sports Exerc 37(1):2–9
Schonhofer B et al (1997) Evaluation of a movement detector to measure daily activity in patients with chronic lung disease. Eur Respir J 10(12):2814–9
Bernard S et al (1998) Peripheral muscle weakness in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158(2):629–34
Troosters T, Gosselink R, Decramer M (2001) Exercise training in COPD: how to distinguish responders from nonresponders. J Cardiopulm Rehabil 21(1):10–7
Maltais F et al (1999) Altered expression of myosin heavy chain in the vastus lateralis muscle in patients with COPD. Eur Respir J 13(4):850–4
Schols AM et al (1996) Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax 51(8):819–24
Spruit MA et al (2003) Muscle force during an acute exacerbation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-I. Thorax 58(9):752–6
Decramer M et al (1994) Corticosteroids contribute to muscle weakness in chronic airflow obstruction. Am J Respir Crit Care Med 150(1):11–6
Rahman I, Skwarska E, MacNee W (1997) Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease. Thorax 52(6):565–8
Levine S et al (2002) Bioenergetic adaptation of individual human diaphragmatic myofibers to severe COPD. J Appl Physiol 92(3):1205–13
Berger HJ et al (1979) 1979 Memorial Award Paper. Comparison of exercise right ventricular performance in chronic obstructive pulmonary disease and coronary artery disease: noninvasive assessment by quantitative radionuclide angiocardiography. Invest Radiol 14(5):342–53
Faisy C et al (2000) Bioelectrical impedance analysis in estimating nutritional status and outcome of patients with chronic obstructive pulmonary disease and acute respiratory failure. Intensive Care Med 26(5):518–25
Vermeeren MA et al (2006) Prevalence of nutritional depletion in a large out-patient population of patients with COPD. Respir Med 100(8):1349–55
Schols A (2003) Nutritional modulation as part of the integrated management of chronic obstructive pulmonary disease. Proc Nutr Soc 62(4):783–91
Jorgensen NR et al (2007) The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease – a cross sectional study. Respir Med 101(1):177–85
Guell R et al (2006) Impact of pulmonary rehabilitation on psychosocial morbidity in patients with severe COPD. Chest 129(4):899–904
Light RW et al (1985) Prevalence of depression and anxiety in patients with COPD. Relationship to functional capacity. Chest 87(1):35–8
Kayahan B et al (2006) Psychological outcomes of an outpatient pulmonary rehabilitation program in patients with chronic obstructive pulmonary disease. Respir Med 100(6):1050–7
Emery CF et al (1991) Psychological outcomes of a pulmonary rehabilitation program. Chest 100(3):613–7
Nici L, ZuWallack R, Wouters E, Donner (2006) On pulmonary rehabilitation and the flight of the bumblebee. Eur Respir J 28:461–462
American Association of Cardiovascular and Pulmonary Rehabilitation (2007). Guidelines for pulmonary rehabilitation programs. In: ZuWallack RZ, Crouch R (eds.) Human Kinetics, Champaign, IL 3rd edn
ZuWallack RL, Patel K, Reardon JZ, Clark BA, Normandin EA (1991) Predictors of improvement in the 12-minute walking distance following a six-week outpatient pulmonary rehabilitation program. Chest 99:805–808
American Thoracic Society/American College of Chest Physicians (2003) ATS/ACCP statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 167:211–277
Sala E, Roca J, Marrades RM, Alonso J, Gonzalez De Suso JM, Moreno A, Barbera JA, Nadal J, DE Jover L, Rodriguez-Roisin R, Wagner PD (1999) Effects of endurance training on skeletal muscle bioenergetics in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 159:1726–1734
Bernard S, Whittom F, LeBlanc P, Jobin J, Belleau R, Berube C, Carrier G, Maltais F (1999) Aerobic and strength training in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 159:896–900
Maltais F, LeBlanc P, Simard C, Jobin J, Berube C, Bruneau J, Carrier L, Belleau R (1996) Skeletal muscle adaptation to endurance training in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 154:442–447
Puhan MA, Scharplatz M, Troosters T, Steurer J (2005) Respiratory rehabilitation after acute exacerbation of COPD may reduce risk for readmission and mortality – a systematic review. Respir Res 6:54
Emery CF, Leatherman NE, Burker EJ, MacIntyre NR (1991) Psychological outcomes of a pulmonary rehabilitation program. Chest 100:613–617
Emery CF, Schein RL, Hauck ER, MacIntyre NR (1998) Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary disease. Health Psychol 17:232–240
O’Donnell DE, McGuire M, Samis L, Webb KA (1995) The impact of exercise reconditioning on breathlessness in severe chronic airflow limitation. Am J Respir Crit Care Med 152:2005–2013
Green RH, Singh SJ, Williams J, Morgan MD (2001) A randomised controlled trial of four weeks versus seven weeks of pulmonary rehabilitation in chronic obstructive pulmonary disease. Thorax 56:143–145
Plankeel JF, McMullen B, MacIntyre NR (2005) Exercise outcomes after pulmonary rehabilitation depend on the initial mechanisms of exercise limitation among non-oxygen-dependent COPD patients. Chest 127(1):110–116
Rossi G, Florini F, Romagnoli M, Bellatone T, Lucic S, Lugli D, Clini E (2005) Length and clinical effectiveness of pulmonary rehabilitation in outpatients with chronic airway obstruction. Chest 127:105–109
Lacasse Y, Brosseau L, Milne S, Martin S, Wong E, Guyatt GH, Goldstein RS (2002) Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 3:CD003793
Ringbaek TJ, Broendum E, Hemmingsen L, Lybeck K, Nielsen D, Andersen C, Lange P (2000) Rehabilitation of patients with chronic obstructive pulmonary disease. Exercise twice a week is not sufficient! Respir Med 94:150–154
Puente-Maestu L, Sanz ML, Sanz P, Cubillo JM, Mayol J, Casaburi R (2000) Comparison of effects of supervised versus self-monitored training programs in patients with chronic obstructive pulmonary disease. Eur Respir J 15:517–525
Vallet G, Ahmaidi S, Serres I, Fabre C, Bourgouin D, Desplan J, Varray A, Prefaut C (1997) Comparison of two training programmes in chronic airway limitation patients: standardized versus individualized protocols. Eur Respir J 10:114–122
Punzal PA, Ries AL, Kaplan RW, Prewitt LM (1991) Maximum intensity exercise training in patients with chronic obstructive pulmonary disease. Chest 100:618–623
Horowitz MB, Littenberg B, Mahler DA (1996) Dyspnea ratings for prescribing exercise intensity in patients with COPD. Chest 109:1169–1175
Clark CJ, Cochrane L, Mackay E (1996) Low intensity peripheral muscle conditioning improves exercise tolerance and breathlessness in COPD. Eur Respir J 9:2590–2596
Normandin EA, McCusker C, Connors M, Vale F, Gerardi D, ZuWallack RL (2002) An evaluation of two approaches to exercise conditioning in pulmonary rehabilitation. Chest 121:1085–1091
Gosselink R, Troosters T, Decramer M (1998) Effects of exercise training in COPD patients; interval versus endurance training. Eur Respir J 12:2S
Lake FR, Henderson K, Briffa T, Openshaw J, Musk AW (1990) Upper-limb and lower-limb exercise training in patients with chronic airflow obstruction. Chest 97:1077–1082
Couser JI Jr, Martinez FJ, Celli BR (1993) Pulmonary rehabilitation that includes arm exercise reduces metabolic and ventilatory requirements for simple arm elevation. Chest 103:37–41
Epstein SK, Celli BR, Martinez FJ, Couser JI, Roa J, Pollock M, Benditt JO (1997) Arm training reduces the VO2 and VE cost of unsupported arm exercise and elevation in chronic obstructive pulmonary disease. J Cardiopulm Rehabil 17:171–177
Simpson K, Killian K, McCartney N, Stubbing DG, Jones NL (1992) Randomised controlled trial of weightlifting exercise in patients with chronic airflow limitation. Thorax 47:70–7
Spruit MA, Gosselink R, Troosters T, De Paepe C, Decramer M (2002) Resistance versus endurance training in patients with COPD and skeletal muscle weakness. Eur Respir J 19:1072–1078
O’Shea SD, Taylor NF, Paratz J (2004) Peripheral muscle strength training in COPD: a systematic review. Chest 126:903–914
Lareau SC, Insel KC (2000) Chapter 6. Patient and family education. In: Hodgkin JE, Celli BR, Connors GL (eds) Pulmonary rehabilitation, Human Kinetics, Champaign, IL 3rd edn
Bandura A (1977) Self-efficacy: toward a unifying theory of behavioral change. Psychol Rev 84:191–215
Bodenheimer T, Lorig K, Holman H, Grumbach K (2002) Patient self-management of chronic disease in primary care. JAMA 288(19):2469–2475
Bourbeau J, Nault D, Dang-Tan T (2004) Self-management and behaviour modification in COPD. Patient Educ Couns 53:271–277
Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA (2002) Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 57:847–852
Spruit MA, Gosselink R, Troosters T, Kasran A, Gayan-Ramirez G, Bogaerts P, Bouillon R, Decramer M (2003) Muscle force during an acute exacerbation in hospitalized patients with COPD and its relationship with CXCL8 and IGF-I. Thorax 59(9):741–2
Seemungal TA, Donaldson GC, Paul EA, Bestall JC, Jefferies DJ, Wedzicha JA (1998) Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 157:1418–1422
Andersson F, Borg S, Jansson SA, Jonsson AC, Ericsson A, Prutz C et al (2002) The costs of exacerbations in chronic obstructive pulmonary disease. Respir Med 96:700–708
Price MJ, Hurrell C (1999) Health care costs of treating exacerbations of COPD. Eur Respir J 14(Suppl 30):S380
Connors AF Jr, Dawson NV, Thomas C, Harrell FE Jr, Desbiens N, Fulkerson WJ, Kussin P, Bellamy P, Goldman L, Knaus WA (1996) Outcomes following acute exacerbation of severe chronic obstructive lung disease. Am J Respir Crit Care Med 154(4 pt 1):959–67
Wilkinson T, Donaldson G, Hurst J, Seemungal T, Wedzicha J (2004) Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 169:1298–1303
Bourbeau J, Julien M, Maltais F, Rouleau M, Beaupre A, Begin R, Renzi P, Nault D, Borycki E, Schwartzman K, Singh R, Collet JP (2003) Chronic obstructive pulmonary disease axis of the respiratory network Fonds de la Recherche en Sante du Quebec. Reduction of hospital utilization in patients with chronic obstructive pulmonary disease. Arch Int Med 163(5):585–91
Hefner JE, Fahy B, Hilling L, Barbieri C (1996) Attitudes regarding advance directives among patients in pulmonary rehabilitation. Am J Respir Crit Care Med 154:1735–1740
Heffner JE (2000) Role of pulmonary rehabilitation in palliative care. Respir Care 45(11):1371–1375
Gosselink R (2003) Controlled breathing and dyspnea in patients with chronic obstructive pulmonary disease. J Rehabil Res Develop 40:25–34
Jones AP, Rowe BH (2000) Bronchopulmonary hygiene physical therapy for chronic obstructive pulmonary disease and bronchiectasis. Cochrane Database Syst Rev 2:CD000045
Organization WH (2003) Adherence to long-term therapies: evidence for action. Annex 1:143
Troosters T, Gosselink R, Decramer M (2000) Short- and long-term effects of outpatient rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial. Am J Med 109(3):207–12
Engelen MPKJ, Schols AMWJ, Baken WC, Wesseling GJ, Wouters EF (1994) Nutritional depletion in relation to respiratory and peripheral skeletal muscle function in outpatients with COPD. Eur Respir J 7:1793–1797
Schols AMWJ, Soeters PB, Dingemans AMC, Mostert R, Frantzen PJ, Wouters EF (1993) Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation. Am Rev Respir Dis 147:1151–1156
Schols AMWJ, Fredrix EW, Soeters PB, Westerterp KR, Wouters EFM (1991) Resting energy expenditure in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 5:983–987
Engelen MPKJ, Schols AMWJ, Heidendal GAK, Wouters EFM (1998) Dual-energy X-ray absorptiometry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 68:1298–1303
Mostert R, Goris A, Weling-Scheepers C, Wouters EF, Schols AM (2000) Tissue depletion and health related quality of life in patients with chronic obstructive pulmonary disease. Respir Med 94(9):859–867
Schols AM, Slangen J, Volovics L, Wouters EF (1998) Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 157(6 Pt 1):1791–1797
Wilson DO, Rogers RM, Wright EC, Anthonisen NR (1989) Body weight in chronic obstructive pulmonary disease. The National Institutes of Health Intermittent Positive-Pressure Breathing Trial. Am Rev Respir Dis 139(6):1435–1438
Landbo C, Prescott E, Lange P, Vestbo J, Almdal TP (1999) Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160(6):1856–1861
Steiner MC, Barton RL, Singh SJ, Morgan MD (2003) Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: a randomised controlled trial. Thorax 58(9):745–751
Efthimiou J, Fleming J, Gomes C, Spiro SG (1988) The effect of supplementary oral nutrition in poorly nourished patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 137(5):1075–1082
Franssen FM, Broekhuizen R, Janssen PP, Wouters EF, Schols AM (2004) Effects of whole-body exercise training on body composition and functional capacity in normal-weight patients with COPD. Chest 125(6):2021–2028
Schols AM, Soeters PB, Mostert R, Pluymers RJ, Wouters EF (1995) Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-controlled randomized trial. Am J Respir Crit Care Med 152:1268–1274
Casaburi R, Bhasin S, Cosentino L, Porszasz J, Somfay A, Lewis MI et al (2004) Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 170(8):870–878
Singer HK, Ruchinskas RA, Riley KC (2001) The psychological impact of end-stage lung disease. Chest 120:1246–1252
Mills TL (2001) Comorbid depressive symptomatology: isolating the effects of chronic medical conditions on self-reported depressive symptoms among community-dwelling older adults. Soc Sci Med 53:569–578
Yohannes AM, Baldwin RC, Connolly MJ (2003) Prevalence of sub-threshold depression in elderly patients with chronic obstructive pulmonary disease. Int J Geriatr Psychiatry 18(5):412–416
Lacasse Y, Rousseau L, Maltais F (2001) Prevalence of depressive symptoms and depression in patients with severe oxygen-dependent Chronic Obstructive Pulmonary Disease. J Cardiopulm Rehabil 21(2):80–86
Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–70
Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561–571
Pulmonary rehabilitation (1999) American thoracic society. Am J Respir Crit Care Med 159(5 Pt 1):1666–82
Strijbos JH et al (1996) A comparison between an outpatient hospital-based pulmonary rehabilitation program and a home-care pulmonary rehabilitation program in patients with COPD. A follow-up of 18 months. Chest 109(2):366–72
Lareau SC, Meek PM, Press D, Anholm JD, Roos PJ (1999) Longitudinal assessment of dyspnea in patients with chronic obstructive pulmonary disease. Heart Lung 28:65–73
Garcia-Aymerich J, Lange P, Benet M, Schnohr P, Anto JM (2006 Sep) Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population based cohort study. Thorax 61(9):772–778
Pitta F, Troosters T, Probst VS, Spruit MA, Decramer M, Gosselink R (2005) Characteristics of physical activities in daily life in COPD. Am J Respir Crit Care Med 171:972–977
Pitta F, Troosters T, Probst VS, Spruit MA, Decramer M, Gosselink R (2006 Mar) Physical activity and hospitalization for exacerbation of COPD. Chest 129(3):536–44
Garcia-Aymerich J, Felez MA, Escarrabill J, Marrades RM, Morera J, Elosua R, Anto JM (2004 Oct) Physical activity and its determinants in severe chronic obstructive pulmonary disease. Med Sci Sports Exerc 36(10):1667–73
Sewell L, Singh S, Williams J, Collier R, Morgan M (2005) Can individualized rehabilitation improve functional indenendence in elderly patients with COPD? Chest 128:1194–1200
Bowen JB, Votto JJ, Thrall RS, Campbell M, Stockdale-Woolley R, Bandyopadhyay T, ZuWallack R (2000) Functional status and survival following pulmonary rehabilitation. Chest 118:697–703
Ringbaek TJ, Lange P (2005 May) Outdoor activity and performance status as predictors of survival in hypoxaemic chronic obstructive pulmonary disease (COPD). Clin Rehabil 19(3):331–8
Garcia-Aymerich J, Lange P, Benet M, Schnohr P, Anto JM (2006 Sep) Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population based cohort study. Thorax 61(9):772–8
Raskin J, Spiegler P, McCusker C, ZuWallack R, Bernstein M, Busby J, DiLauro P, Griffiths K, Haggerty M, Hovey L, McEvoy D, Reardon JZ, Stavrolakes K, Stockdale-Woolley R, Thompson P, Trimmer G, Youngson L (2006) he effect of pulmonary rehabilitation on healthcare utilization in chronic obstructive pulmonary disease: the northeast pulmonary rehabilitation consortium. J Cardiopulm Rehabil 26:231–6
Puhan MA, Scharplatz M, Troosters T, Steurer J (2005) Respiratory rehabilitation after acute exacerbation of COPD may reduce risk for readmission and mortality – a systematic review. Respir Res 6:54
O’Donnell DE, Revill SM, Webb KA (2001) Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164:770–777
Cooper CB (2006 Oct) The connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and function. Am J Med 119(10 Suppl 1):21–31
Porszasz J, Emtner M, Goto S, Somfay A, Whipp BJ, Casaburi R (2005) Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD. Chest 128:2025–34
Casaburi R, Patessio A, Ioli F, Zanaboni S, Donner CF, Wasserman K (1991) Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease. Am Rev Respir Dis 143:9–18
Puente-Maestu L, Sanz ML, Sanz P, Ruiz de Ona JM, Rodriguez-Hermosa JL, Whipp BJ (2000) Effects of two types of training on pulmonary and cardiac responses to moderate exercise in patients with COPD. Eur Respir J 15:1026–1032
Maltais F, LeBlanc P, Jobin J (1997) Intensity of training and physiological adaptation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 155:555–561
O’Donnell DE, Voduc N, Fitzpatrick M, Webb KA (2004) Effect of salmeterol on the ventilatory response to exercise in COPD. Eur Respir J 24(1):86–94
Maltais F, Hamilton A, Marciniuk D, Hernandez P, Sciurba FC, Richter K, Kesten S, O’Donnell D (2005 Sep) Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD. Chest 128(3):1168–78
Appleton S, Smith B, Veale A, Bara A (2002) Long-acting beta2-agonists for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 3:CD001104
O’Donnell DE, Lam M, Webb KA (1998) Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158:1557–1565
O’Donnell DE, Lam M, Webb KA (1999) Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160:542–549
Saey D, Debigare R, LeBlanc P, Mador MJ, Cote CG, Jobin J, Maltais F (2003) Contractile leg fatigue after cycle exercise. A factor limiting exercise in patients with COPD. Am J Respir Crit Care Med 168:425–430
Casaburi R, Kukafka D, Cooper CB, Witek TJ, Kesten S (2005) Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD. Chest 127:809–817
The Nocturnal Oxygen Therapy Group (1980) Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease. Ann Intern Med 93:391–398
Medical Research Council Working Party (1981) Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Lancet 8222:681–686
Bradley JM, O’Neill B (Oct 2005) Short-term ambulatory oxygen for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 19(4):CD004356
LaCasse Y, Lecours R, Pelletier C, Begin R, Maltais F (2005) Randomised trial of ambulatory oxygenin oxygen-dependent COPD. Eur Respir J 25:1032–1038
Somfay A, Porszasz J, Lee SM, Casaburi R (2001) Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxemic COPD patients. Eur Respir J 18:77–84
Rooyackers JM, Dekhuijzen PNR, Van Herwaarden CLA, Folgering HTM (1997) Training with supplemental oxygen in patients with COPD and hypoxemia at peak exercise. Eur Respir J 10:1278–1284
Garrod R, Paul EA, Wedzicha JA (2000) Supplemental oxygen during pulmonary rehabilitation in patients with COPD with exercise hypoxaemia. Thorax 55:539–543
Wadell K, Henriksson-Larsen K, Lundgren R (2001) Physical training with and without oxygen in patients with chronic obstructive pulmonary disease adn exercise-induced hypoxaemia. J Rehab Med 33:200–205
Emtner M, Porszasz J, Burns M, Somfay A, Casaburi R (2003) Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructive pulmonary disease patients. Am J Respir Crit Care Med 168:1034–1042
Ries AL, Kaplan RM, Limberg TM, Prewitt LM (1995) Effects of pulmonary rehabilitation on physiologic and psychosocial outcomes in patients with chronic obstructive pulmonary disease. Ann Intern Med 122:823–832
Brooks D, Krip B, Mangovski-Alzamora S, Goldstein RS (2002) The effect of postrehabilitation programmes among individuals with chronic obstructive pulmonary disease. Eur Respir J 20:20–29
Ries AL, Kaplan RM, Myers R et al (2003) Maintenance after pulmonary rehabilitation in chronic lung disease: a randomized trial. Am J Respir Crit Care Med 167:880–888
Troosters T, Gosselink R, Decramer M (2000) Short- and long-term effects of outpatient rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial. Am J Med 109(3):207–12
Guyatt GH, Berman LB, Townsend M, Pugsley SO, Chambers LW. (1987) A measure of quality of life for clinical trials in chronic lung disease. Thorax 42:773–778.
Reardon J, Awad E, Normandin E, Vale F, Clark B, and ZuWallack RL (1994) The effect of comprehensive outpatient pulmonary rehabilitation on dyspnea. Chest 105:1046–1052.
ZuWallack RZ, Crouch R editors (2004) American Association of Cardiovascular and Pulmonary Rehabilitation. Guidelines for pulmonary rehabilitation programs, 3rd edition, Human Kinetics 2004.
ZuWallack R, Lareau S, Meek P. (2004) The effect of pulmonary rehabilitation on dyspnea. In Lung biology in health and disease: Dyspnea. Mahler D, editor. New York:Marcel Decker, Inc.
Lacasse Y, Brosseau L, Milne S, Martin S, Wong E, Guyatt GH, Goldstein RS. (2002) Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. (3):CD003793.
Lacasse Y, Wong E, Guyatt GH et al. (1996) Meta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease. Lancet 348:1115–1119
Haggerty MC, Stockdale-Woolley R, ZuWallack R. (1999) Functional status in pulmonary rehabilitation participants. J Cardiopulmonary Rehabil 19:35–42.
Griffiths TL, Burr ML, Campbell IA et al. (2000) Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomised controlled trial. Lancet 355:362–368.
Griffiths TL, Phillips CJ, Davies S et al. (2001) Cost effectiveness of an outpatient multidisciplinary pulmonary rehabilitation programme. Thorax 56:779-784
California Pulmonary Rehabilitation Collaborative Group. Effects of pulmonary rehabilitation on dyspnea, quality of life and health care costs in California. J Cardiopulmonary Rehabil 2004; 24:52–62.
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Lan, C.K., Nici, L., Wallack, R.Z. (2011). Pulmonary Rehabilitation. In: Hanania, N., Sharafkhaneh, A. (eds) COPD. Respiratory Medicine. Humana Press. https://doi.org/10.1007/978-1-59745-357-8_10
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