Bone Pathology

pp 285-345


The Surgical Pathology of Bone Tumors and Tumor-Like Lesions

  • Jasvir S. KhuranaAffiliated withDepartment of Pathology, Temple Univesity School of Medicine Email author 

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Primary bone tumors, especially malignant ones, are rare and so unfamiliarity on a day-to-day basis with the various entities adds to the difficulty with their diagnosis and management within the entire clinical team including the surgeon, radiologist, pathologist, and internist or medical oncologist. This chapter takes an overview of the most important of the benign and malignant primary bone tumors. A section on differential diagnosis is included to help the surgical pathologist in diagnosis. This chapter emphasizes a good coordination with radiologists, clinicians, and pathologists to come to the correct diagnosis.


Unicameral bone cyst Aneurysmal bone cyst Synovial cyst Intraosseous ganglion Enostosis Osteoma Osteoid osteoma Osteoblastoma Osteosarcoma Periosteal osteosarcoma Parosteal osteosarcoma Secondary bone tumors Telangiectatic osteosarcoma Chondroblastic Osteoblastic Fibroblastic Giant cell rich Low-grade intraosseous High-grade surface Neoadjuvantchemotherapy Small cell Osteochondroma Nora’s lesion Chondroma Chondroblastoma Chondromyxoid fibroma Chondrosarcoma Exostosis Enchondromatosis Ollier’s disease Clear cell chondrosarcoma Mesenchymal chondrosarcoma Dedifferentiated chondrosarcoma Hemangioma Angiomatosis Gorham’s disease Epitheloid hemangioendothelioma Angiosarcoma Hemangiopericytoma Solitary fibrous tumor Glomus tumor Giant cell tumor (GCT) Giant cell reparative granuloma Desmoplastic fibromaFibrosarcoma Benign fibrous histiocytoma Nonossifying fibroma (NOF) Malignant fibrous histiocytoma Fibrous dysplasia (FD) Osteofibrous dysplasia Adamantinoma Ewing’s sarcoma Intraosseous lipoma Intraosseous liposarcoma Leio- myosarcoma Intraosseous schwannoma Chordoma Chondroid chordoma Plasma cell myeloma Leukemia Granulocytic sarcoma Non-Hodgkin’s disease Hodgkin’s disease Langerhans cell histiocytosis (LCH) Erdheim-Chester disease