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Matrix-Induced Autologous Chondrocyte Implantation

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Cartilage Repair Strategies

Abstract

Matrix-induced autologous chondrocyte implantation (MACI) by means of direct inoculation of chondrocytes on a type I/IV collagen membrane for surgical implantation is less invasive and obviates periosteal harvest and suturing in most cases. It allows manufacturers to deliver a standard cell density for implantation. This chapter describes the characteristics of collagen membrane and the surgical procedures of MACI. The early clinical results based on 43 implantations in 40 patients were reported. It concluded that MACI achieves a comparable functional and histological outcomes as does conventional ACI technology.

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Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Nedlands, Western Australia, Australia

    David Wood MBBS, MS, FRCS, FRACS (Head of Unit, Director)

  2. Perth Orthopaedic Instiute, Perth Bone and Tissue Bank, University of Western Australia, Nedlands, Western Australia, Australia

    David Wood MBBS, MS, FRCS, FRACS (Head of Unit, Director)

  3. Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Western Australia, Nedlands, Western Australia, Australia

    Ming Hao Zheng PhD, DM, FRCPath (Director of Research)

Authors
  1. David Wood MBBS, MS, FRCS, FRACS
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  2. Ming Hao Zheng PhD, DM, FRCPath
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Editor information

Editors and Affiliations

  1. Weill Medical College of Cornell University, USA

    Riley J. Williams III MD (Associate Professor of Orthopaedic Surgery, Attending Orthopaedic Surgeon Director) (Associate Professor of Orthopaedic Surgery, Attending Orthopaedic Surgeon Director)

  2. Institute for Cartilage Repair, Hospital for Special Surgery, New York, NY

    Riley J. Williams III MD (Associate Professor of Orthopaedic Surgery, Attending Orthopaedic Surgeon Director) (Associate Professor of Orthopaedic Surgery, Attending Orthopaedic Surgeon Director)

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© 2007 Humana Press Inc., Totowa, NJ

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Wood, D., Zheng, M.H. (2007). Matrix-Induced Autologous Chondrocyte Implantation. In: Williams, R.J. (eds) Cartilage Repair Strategies. Humana Press. https://doi.org/10.1007/978-1-59745-343-1_12

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  • DOI: https://doi.org/10.1007/978-1-59745-343-1_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-629-0

  • Online ISBN: 978-1-59745-343-1

  • eBook Packages: MedicineMedicine (R0)

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