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Cooperation Between TGF-β and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function

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Book cover Transforming Growth Factor-β in Cancer Therapy, Volume I

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Stem cells have become a subject of intensive research based on their potential for varied clinical applications. One such stem cell, the mesenchymal stem cell, has attracted attention owing to its ability to differentiate into several mesenchymal lineages such as bone, cartilage, and fat. The molecular pathways which regulate the functions of mesenchymal stem cells are not well-characterized, but the TGF-β and Wnt signaling pathways are thought to play critical roles. Here, we describe the importance of TGF-β and Wnt signaling pathway crosstalk in governing mesenchymal stem cell function.

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Authors and Affiliations

  1. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA

    Irwin M. Liu BSc, Stephen H. Schilling AB & Xiao-Fan Wang PhD

Authors
  1. Irwin M. Liu BSc
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  2. Stephen H. Schilling AB
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  3. Xiao-Fan Wang PhD
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© 2008 Humana Press

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Liu, I.M., Schilling, S.H., Wang, XF. (2008). Cooperation Between TGF-β and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function. In: Transforming Growth Factor-β in Cancer Therapy, Volume I. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-292-2_18

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  • DOI: https://doi.org/10.1007/978-1-59745-292-2_18

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-714-3

  • Online ISBN: 978-1-59745-292-2

  • eBook Packages: MedicineMedicine (R0)

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