Abstract
The prostate stem cell concept described in this chapter was studied in our laboratory, where we provided experimental immunophenotypic evidence of the presence of keratin, androgen receptor, neuroendocrine markers, and c-Met protooncogene in unique populations of normal developing and malignant human prostate epithelial cells. The characteristic responses of these stem cells to growth factors and neoadjuvant hormonal therapy supported the cancer stem cell concept, and, if successfully applied to human prostate cancer specimens, could reveal new therapeutic targets.
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© 2007 Humana Press Inc., Totowa, NJ
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Schalken, J.A. (2007). Prostate (Cancer) Stem Cells. In: Chung, L.W.K., Isaacs, W.B., Simons, J.W. (eds) Prostate Cancer. Contemporary Cancer Research. Humana Press. https://doi.org/10.1007/978-1-59745-224-3_4
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DOI: https://doi.org/10.1007/978-1-59745-224-3_4
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