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Preclinical Effects of Opioid Antagonists on Feeding and Appetite

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Book cover Opiate Receptors and Antagonists

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

A large component of the evidence linking the endogenous opioid system to the control of food intake and body weight has been derived from the ability of general and selective opioid antagonists to block food intake under a number of homeostatically mediated and reward-mediated conditions. This chapter will examine the role of general and specific opioid receptor subtype antagonist involvement in the mediation of (1) the palatable and hedonic aspects of food intake and food choice, including ingestion of simple sugars and fats; (2) the ingestive response to homeostatic regulatory challenges including food deprivation, glucoprivation, and lipoprivation; (3) body weight regulation in normophagic, genetically-obese, diet-obese and stressed animals; and (4) pharmacologically-induced feeding. Detailed description of the central sites of antagonist will be provided, as well as comparing opioid antagonist effects with those derived from molecular gene expression and knockout and knockdown (antisense) approaches. The pervasive effects of opioid antagonists on the different aspects of feeding behavior make the development of more selective antagonist peptide analogues and drugs attractive target systems for the treatment of obesity and diabetes and intake of macronutrients associated with these important dysfunctions.

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    Richard J. Bodnar

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  1. Life Sciences/Toxicology, Alkermes, Inc., Cambridge, MA, 02139, USA

    Reginald L. Dean III

  2. Department of Pharmacology, College of Osteopathic Medicine, University of New England, Biddleford, ME, 04005, USA

    Edward J. Bilsky

  3. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA

    S. Stevens Negus

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© 2009 Springer Science+Business Media, LLC

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Bodnar, R.J. (2009). Preclinical Effects of Opioid Antagonists on Feeding and Appetite. In: Dean, R.L., Bilsky, E.J., Negus, S.S. (eds) Opiate Receptors and Antagonists. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59745-197-0_20

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