Abstract
Recently, several components of the mammalian meiotic recombination pathway have been identified and new immunofluorescence approaches to the analysis of human meiosis have been developed. This has made it possible to directly examine the dynamics of chromosome behavior in meiosis I spermatocytes and address previously intractable questions, such as: How do chromosomes pair and synapse with one another? How does recombination occur? What is the relationship—if any—between abnormalities in meiosis and cases of unexplained male infertility? In this chapter, we discuss results from immunocytogenetic studies of human males, summarizing how they have contributed to our understanding of both normal and abnormal spermatogenesis.
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Topping, D., Brown, P., Hassold, T. (2007). The Immunocytogenetics of Human Male Meiosis. In: Carrell, D.T. (eds) The Genetics of Male Infertility. Humana Press. https://doi.org/10.1007/978-1-59745-176-5_7
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DOI: https://doi.org/10.1007/978-1-59745-176-5_7
Publisher Name: Humana Press
Print ISBN: 978-1-58829-863-8
Online ISBN: 978-1-59745-176-5
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