Skip to main content

The Future of the Diagnosis of Male (In) Fertility

  • Chapter
Book cover The Genetics of Male Infertility

Abstract

Traditionally, the diagnosis of male (in)fertility has relied on the results from clinical evaluation and semen analysis. Although these approaches have undeniable merit, often times causes for subfertility are more covert and are not readily identified by these traditional approaches. In these instances, the diagnosis is simply written as idio-pathic or undiagnosed. The genomic and proteomic eras have promised great potential to remedy those cases defined as undiagnosed and further advance our understanding of the complex processes that combine and contribute to the so-called fertile and infertile male.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ayala C, Steinberger E, Smith DP. The influence of semen analysis parameters on the fertility potential of infertile couples. J Androl 1996;17:718–725.

    PubMed  CAS  Google Scholar 

  2. Barratt CL, Naeeni M, Clements S, Cooke ID. Clinical value of sperm morphology for in-vivo fertility: comparison between World Health Organization criteria of 1987 and 1992. HumReprod 1995;10:587–593.

    CAS  Google Scholar 

  3. Bonde JP, Ernst E, Jensen TK, et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet 1998;352:1172–1177.

    Article  PubMed  CAS  Google Scholar 

  4. Chia SE, Tay SK, Lim ST. What constitutes a normal seminal analysis? Semen parameters of 243 fertile men. Hum Reprod 1998;13:3394–3398.

    Article  PubMed  CAS  Google Scholar 

  5. Chia SE, Lim ST, Tay SK, Lim ST. Factors associated with male fertility: a case-control study of 218 infertile and 240 fertile men. BJOG 2000;107:55–61.

    Article  PubMed  CAS  Google Scholar 

  6. van der Merwe FH, Kruger TF, Oehninger SC, Lombard CJ. The use of semen parameters to identify the subfertile male in the general population. Gynecol Obstet Invest 2005;59:86–91.

    Article  PubMed  Google Scholar 

  7. World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. Cambridge University Press, Cambridge; 1999.

    Google Scholar 

  8. Oehninger S, Franken D. Testing sperm manufacturing quality: the sperm-zona binding assay. In: De Jonge C, Barratt C, eds. The Sperm Cell. Production, Maturation, Fertilization, Regeneration. Cambridge University Press, Cambridge; 2006;194–216.

    Google Scholar 

  9. Shefi S, Turek PJ. Sex chromosome abnormalities and male infertility: a clinical perspective. In: De Jonge C, Barratt C, eds. The Sperm Cell. Production, Maturation, Fertilization, Regeneration. Cambridge University Press, Cambridge; 2006; 261–278.

    Google Scholar 

  10. Vogt PH. Genetics: a basic science perspective. In: De Jonge C, Barratt C, eds. The Sperm Cell. Production, Maturation, Fertilization, Regeneration. Cambridge University Press, Cambridge; 2006;217–260.

    Google Scholar 

  11. Evenson DP, Larson KJ, Jost LK. Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 2002;23:25–43.

    PubMed  Google Scholar 

  12. Chohan KR, Griffin JT, LaFromboise M, De Jonge CJ, Carrell DT. Comparison of chromatin assays for DNA fragmentation evaluation in human sperm. J Androl 2006;27:53–59.

    Article  PubMed  CAS  Google Scholar 

  13. Henkel R, Hajimohammad M, Stalf T, et al. Influence of deoxyribonucleic acid damage on fertilization and pregnancy. Fertil Steril 2004; 81:965–972.

    Article  PubMed  CAS  Google Scholar 

  14. De Jonge C. The clinical value of sperm nuclear DNA assessment. Hum Fertil (Camb)2002;5:51–53.

    Article  Google Scholar 

  15. Riddell D, Pacey A, Whittington K. Lack of compliance by UK andrology laboratories with World Health Organization recommendations for sperm morphology assessment. Hum Reprod 2005;20:3441–3445.

    Article  PubMed  Google Scholar 

  16. World Health Organization. WHO manual for the standardized investigation, diagnosis and management of the infertile male. Cambridge University Press, Cambridge; 2000.

    Google Scholar 

  17. Gianotten J, Lombardi MP, Zwinderman AH, Lilford RJ, van der Veen F. Idiopathic impaired spermatogenesis: genetic epidemiology is unlikely to provide a short-cut to better understanding. Hum Reprod Update 2004;10:533–539.

    Article  PubMed  Google Scholar 

  18. Moldenhauer JS, Ostermeier GC, Johnson A, Diamond MP, Krawetz SA. Diagnosing male factor infertility using microarrays. J Androl 2003;24:783–789.

    PubMed  Google Scholar 

  19. La Salle S, Trasler JM. Epigenetic patterning in male germ cells: importance of DNA methylation to progeny outcome. In: De Jonge C, Barratt C, eds. The Sperm Cell. Production, Maturation, Fertilization, Regeneration. Cambridge University Press, Cambridge; 2006;279–322.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Humana Press Inc.

About this chapter

Cite this chapter

De Jonge, C. (2007). The Future of the Diagnosis of Male (In) Fertility. In: Carrell, D.T. (eds) The Genetics of Male Infertility. Humana Press. https://doi.org/10.1007/978-1-59745-176-5_17

Download citation

Publish with us

Policies and ethics