Abstract
Traditionally, the diagnosis of male (in)fertility has relied on the results from clinical evaluation and semen analysis. Although these approaches have undeniable merit, often times causes for subfertility are more covert and are not readily identified by these traditional approaches. In these instances, the diagnosis is simply written as idio-pathic or undiagnosed. The genomic and proteomic eras have promised great potential to remedy those cases defined as undiagnosed and further advance our understanding of the complex processes that combine and contribute to the so-called fertile and infertile male.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ayala C, Steinberger E, Smith DP. The influence of semen analysis parameters on the fertility potential of infertile couples. J Androl 1996;17:718–725.
Barratt CL, Naeeni M, Clements S, Cooke ID. Clinical value of sperm morphology for in-vivo fertility: comparison between World Health Organization criteria of 1987 and 1992. HumReprod 1995;10:587–593.
Bonde JP, Ernst E, Jensen TK, et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet 1998;352:1172–1177.
Chia SE, Tay SK, Lim ST. What constitutes a normal seminal analysis? Semen parameters of 243 fertile men. Hum Reprod 1998;13:3394–3398.
Chia SE, Lim ST, Tay SK, Lim ST. Factors associated with male fertility: a case-control study of 218 infertile and 240 fertile men. BJOG 2000;107:55–61.
van der Merwe FH, Kruger TF, Oehninger SC, Lombard CJ. The use of semen parameters to identify the subfertile male in the general population. Gynecol Obstet Invest 2005;59:86–91.
World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. Cambridge University Press, Cambridge; 1999.
Oehninger S, Franken D. Testing sperm manufacturing quality: the sperm-zona binding assay. In: De Jonge C, Barratt C, eds. The Sperm Cell. Production, Maturation, Fertilization, Regeneration. Cambridge University Press, Cambridge; 2006;194–216.
Shefi S, Turek PJ. Sex chromosome abnormalities and male infertility: a clinical perspective. In: De Jonge C, Barratt C, eds. The Sperm Cell. Production, Maturation, Fertilization, Regeneration. Cambridge University Press, Cambridge; 2006; 261–278.
Vogt PH. Genetics: a basic science perspective. In: De Jonge C, Barratt C, eds. The Sperm Cell. Production, Maturation, Fertilization, Regeneration. Cambridge University Press, Cambridge; 2006;217–260.
Evenson DP, Larson KJ, Jost LK. Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 2002;23:25–43.
Chohan KR, Griffin JT, LaFromboise M, De Jonge CJ, Carrell DT. Comparison of chromatin assays for DNA fragmentation evaluation in human sperm. J Androl 2006;27:53–59.
Henkel R, Hajimohammad M, Stalf T, et al. Influence of deoxyribonucleic acid damage on fertilization and pregnancy. Fertil Steril 2004; 81:965–972.
De Jonge C. The clinical value of sperm nuclear DNA assessment. Hum Fertil (Camb)2002;5:51–53.
Riddell D, Pacey A, Whittington K. Lack of compliance by UK andrology laboratories with World Health Organization recommendations for sperm morphology assessment. Hum Reprod 2005;20:3441–3445.
World Health Organization. WHO manual for the standardized investigation, diagnosis and management of the infertile male. Cambridge University Press, Cambridge; 2000.
Gianotten J, Lombardi MP, Zwinderman AH, Lilford RJ, van der Veen F. Idiopathic impaired spermatogenesis: genetic epidemiology is unlikely to provide a short-cut to better understanding. Hum Reprod Update 2004;10:533–539.
Moldenhauer JS, Ostermeier GC, Johnson A, Diamond MP, Krawetz SA. Diagnosing male factor infertility using microarrays. J Androl 2003;24:783–789.
La Salle S, Trasler JM. Epigenetic patterning in male germ cells: importance of DNA methylation to progeny outcome. In: De Jonge C, Barratt C, eds. The Sperm Cell. Production, Maturation, Fertilization, Regeneration. Cambridge University Press, Cambridge; 2006;279–322.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Humana Press Inc.
About this chapter
Cite this chapter
De Jonge, C. (2007). The Future of the Diagnosis of Male (In) Fertility. In: Carrell, D.T. (eds) The Genetics of Male Infertility. Humana Press. https://doi.org/10.1007/978-1-59745-176-5_17
Download citation
DOI: https://doi.org/10.1007/978-1-59745-176-5_17
Publisher Name: Humana Press
Print ISBN: 978-1-58829-863-8
Online ISBN: 978-1-59745-176-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)