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Polyamine Cell Signaling pp 51–73Cite as

Cellular Signals Mediating Growth Arrest After Polyamine Depletion

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Abstract

The natural polyamines spermidine and spermine and their precursor putrescine are ubiquitous organic cations of low molecular weight in eukaryotic cells and are intimately involved in distinct cellular functions (1,2). For many years, regulation of cellular polyamines has been recognized to be the central convergence point for multiple signaling pathways driving different cellular functions. It has been shown that increased levels of cellular polyamines, either synthesized endogenously or supplied exogenously, are essential for the stimulation of cell proliferation, and that depletion of cellular polyamines inhibits cell proliferation and causes G1 phase growth arrest in a variety of cell types (1–3). To define the exact role of polyamines in cell proliferation at the molecular level, an increasing body of evidence indicates that polyamines regulate cell proliferation by virtue of their ability to modulate expression of various growth-related genes.

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Authors and Affiliations

  1. Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD

    Jian-Ying Wang

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Editors and Affiliations

  1. Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD

    Jian-Ying Wang

  2. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD

    Robert A. Casero Jr.

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© 2006 Humana Press Inc., Totowa, NJ

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Wang, JY. (2006). Cellular Signals Mediating Growth Arrest After Polyamine Depletion. In: Wang, JY., Casero, R.A. (eds) Polyamine Cell Signaling. Humana Press. https://doi.org/10.1007/978-1-59745-145-1_4

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