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HIV Infection and AIDS

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Sexually Transmitted Diseases

Part of the book series: Current Clinical Practice ((CCP))

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Abstract

In the summer of 1981, the Centers for Disease Control and Prevention (CDC) reported clusters of unusual infections (Pneumocystis carinii pneumonia, now called Pneumocystis jiroveci) and tumors (Kaposi sarcoma) among homosexual men in California and New York. This was the beginning of the acquired immune deficiency syndrome (AIDS) pandemic. Initially, infection with the human immunodeficiency virus (HIV) appeared to be associated with homosexual activities, which led to the initial naming of gay-related immune deficiency syndrome. However, it soon became clear that heterosexual and direct blood contact could also transmit the newly recognized pathogen. Since then, HIV infection and AIDS have been spreading rapidly around the world, affecting millions of people and resulting in millions of deaths. In his speech at the 2003 International AIDS Conference in Paris, France, President Nelson Mandela declared HIV/AIDS the “greatest health crisis in human history.”

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References

  1. Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report, 2005 (Vol. 16). Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2005. Available from: http://www.cdc.gov/hiv/stats/hasrlink.htm. Accessed August 1, 2006.

    Google Scholar 

  2. Fleming PL, Byers RH, Sweeney PA, Daniels D, Karon JM, Janssen RS. HIV prevalence in the United States, 2000. In: Programs and Abstracts of the 9th Conference of Retroviruses and Opportunistic Infections. Seattle, WA: February 24–28, 2002, Abstract 11.

    Google Scholar 

  3. Hall HI, Ling Q, Song R, McKenna MT. Recent trends in HIV diagnosis in the United States. In: Programs and Abstracts of the 11th Conference of Retroviruses and Opportunistic Infections; San Francisco, CA: February 8–11, 2004; Abstract 86.

    Google Scholar 

  4. Joint United Nations Program on HIV/AIDS. Report on the global AIDS epidemic. 2006. Geneva: Joint United Nations Programme on HIV/AIDS; 2006. Available from: http://www.unaids.org. Accessed on August 1, 2006.

    Google Scholar 

  5. Sweet RL, Gibbs RS. HIV/AIDS. In: Infectious Diseases of the Female Genital Tract, 4th Ed. Philadelphia, PA: Lippincott Williams &Wilkins; 2002, pp. 238–317.

    Google Scholar 

  6. Clemetson DB, Moss GB, Willerford DM, et al. Detection of HIV DNA in cervical and vaginal secretions. Prevalence and correlates among women in Nairobi, Kenya. JAMA 1993; 269:2860–2864.

    Article  CAS  PubMed  Google Scholar 

  7. Mostad SB, Overbaugh J, DeVange DM, et al. Hormonal contraception, vitamin A deficiency, and other risk factors for shedding of HIV-1 infected cells from the cervix and vagina. Lancet 1997; 350:922–927.

    Article  CAS  PubMed  Google Scholar 

  8. Vernazza PL, Eron JJ, Fiscus SA, Cohen MS. Sexual transmission of HIV: infectiousness and prevention. AIDS 1999; 13:155–166.

    Article  CAS  PubMed  Google Scholar 

  9. Bagasra O, Farzadegan H, Seshamma T, Oakes JW, Saah A, Pomerantz RJ. Detection of HIV-1 proviral DNA in sperm from HIV-1-infected men. AIDS 1994; 8:1669–1674.

    Article  CAS  PubMed  Google Scholar 

  10. Bujan L, Pasquier C, Labeyrie E, Lanusse-Crousse P, Morucci M, Daudin M. Insemination with isolated and virologically tested spermatozoa is a safe way for human immunodeficiency type 1 virus-serodiscordant couples with an infected male partner to have a child. Fertil Steril 2004; 82:857–862.

    Article  PubMed  Google Scholar 

  11. Pasquier C, Daudin M, Righi L, et al. Sperm washing and virus nucleic acid detection to reduce HIV and hepatitis C virus transmission in serodiscordant couples wishing to have children. AIDS 2000; 14:2093–2099.

    Article  CAS  PubMed  Google Scholar 

  12. Krieger JN, Nirapathpongporn A, Chaiyaporn M, et al. Vasectomy and human immunodeficiency virus type 1 in semen. J Urol 1998; 159:820–826.

    Article  CAS  PubMed  Google Scholar 

  13. Tachet A, Dulioust E, Salmon D, et al. Detection and quantification of HIV-1 in semen: identification of a subpopulation of men at high potential risk of viral sexual transmission. AIDS 1999; 13:823–831.

    Article  CAS  PubMed  Google Scholar 

  14. Zuckerman RA, Whittington WL, Celum CL, et al. Higher concentration of HIV RNA in rectal mucosa secretions than in blood and seminal plasma, among men who have sex with men, independent of antiretroviral therapy. J Infect Dis 2004; 190:156–161.

    Article  PubMed  Google Scholar 

  15. Dragic T, Litwin V, Allaway GP, et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996; 381:667–673.

    Article  CAS  PubMed  Google Scholar 

  16. Royce RA, Sena A, Cates WJr, Cohen MS. Sexual transmission of HIV. N Engl J Med 1997; 336:1072–1078.

    Article  CAS  PubMed  Google Scholar 

  17. Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med 2000; 342: 921–929.

    Article  CAS  PubMed  Google Scholar 

  18. Leynaert B, Downs AM, de Vincenzi I. Heterosexual transmission of human immunodeficiency virus: variability of infectivity throughout the course of infection. European Study Group on Heterosexual Transmission of HIV. Am J Epidemiol 1998; 148:88–96.

    Article  CAS  PubMed  Google Scholar 

  19. DeGruttola V, Seage GR III, Mayer KH, Horsburgh CR Jr. Infectiousness of HIV between male homosexual partners. J Clin Epidemiol 1989; 42:849–856.

    Article  CAS  PubMed  Google Scholar 

  20. Mingjia L, Short R. How oestrogen or progesterone might change a woman’s susceptibility to HIV-1 infection. Aust NZJ Obstet Gynaecol 2002; 42:472–475.

    Article  Google Scholar 

  21. Padian NS, Shiboski SC, Glass SO, Vittinghoff E. Heterosexual transmission of human immunodeficiency virus (HIV) in northern California: results from a ten-year study. Am J Epidemiol 1997; 146:350–357.

    Article  CAS  PubMed  Google Scholar 

  22. Nicolosi A, Correa Leite ML, Musicco M, Arici C, Gavazzeni G, Lazzarin A. The efficiency of male-to-female and female-to-male sexual transmission of the human immunodeficiency virus: a study of 730 stable couples. Italian Study Group on HIV Heterosexual Transmission. Epidemiology 1994; 5:570–575.

    Article  CAS  PubMed  Google Scholar 

  23. de Vincenzi I. A longitudinal study of human immunodeficiency virus transmission by heterosexual partners. European Study Group on Heterosexual Transmission of HIV. N Engl J Med 1994; 331:341–346.

    Article  PubMed  Google Scholar 

  24. Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 2001; 357:1149–1153.

    Article  CAS  PubMed  Google Scholar 

  25. Downs AM, De Vincenzi I. Probability of heterosexual transmission of HIV: relationship to the number of unprotected sexual contacts. European Study Group in Heterosexual Transmission of HIV. J Acquir Immune Defic Syndr Hum Retrovirol 1996; 11:388–395.

    Article  CAS  PubMed  Google Scholar 

  26. Mastro TD, Satten GA, Nopkesorn T, Sangkharomya S, Longini IM Jr. Probability of female-to-male transmission of HIV-1 in Thailand. Lancet 1994; 343:204–207.

    Article  CAS  PubMed  Google Scholar 

  27. Satten GA, Mastro TD, Longini IM Jr. Modelling the female-to-male per-act HIV transmission probability in an emerging epidemic in Asia. Stat Med 1994; 13:2097–2106.

    Article  CAS  PubMed  Google Scholar 

  28. European Study Group on Heterosexual Transmission of HIV. Comparison of female to male and male to female transmission of HIV in 563 stable couples. BMJ 1992; 304:809–813.

    Article  Google Scholar 

  29. Edwards S, Carne C. Oral sex and the transmission of viral STIs. Sex Transm Infect 1998; 74:6–10.

    Article  CAS  PubMed  Google Scholar 

  30. Richters J, Grulich A, Ellard J, Hendry O, Kippax S. HIV transmission among gay men through oral sex and other uncommon routes: case series of HIV seroconverters, Sydney. AIDS 2003; 17:2269–2271.

    Article  PubMed  Google Scholar 

  31. Rothenberg RB, Scarlett M, del Rio C, Reznik D, O’Daniels C. Oral transmission of HIV. AIDS 1998; 12:2095–2105.

    Article  CAS  PubMed  Google Scholar 

  32. Varghese B, Maher JE, Peterman A, Branson BM, Steketee RW. Reducing the risk of sexual HIV transmission: quantifying the per-act risk for HIV on the basis of choice of partner, sex act, and condom use. Sex Transm Dis 2002; 29:38–43.

    Article  PubMed  Google Scholar 

  33. Rockstroh JK, Ewig S, Bauer T, et al. Male-to-female transmission of HIV in a cohort of hemophiliacs—frequency, risk factors and effect of sexual counseling. Infection 1995; 23: 29–32.

    Article  CAS  PubMed  Google Scholar 

  34. Shiboski SC, Padian NS. Epidemiologic evidence for time variation in HIV infectivity. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 19:527–535.

    Article  CAS  PubMed  Google Scholar 

  35. O’Brien TR, Busch MP, Donegan E, et al. Heterosexual transmission of human immunodeficiency virus type 1 from transfusion recipients to their sex partners. J Acquir Immune Defic Syndr 1994; 7:705–710.

    PubMed  Google Scholar 

  36. Saracco A, Musicco M, Nicolosi A, et al. Man-to-woman sexual transmission of HIV: longitudinal study of 343 steady partners of infected men. J Acquir Immune Defic Syndr 1993; 6:497–502.

    Article  CAS  PubMed  Google Scholar 

  37. Seidlin M, Vogler M, Lee E, Lee YS, Dubin N. Heterosexual transmission of HIV in acohort of couples in New York City. AIDS 1993; 7:1247–1254.

    Article  CAS  PubMed  Google Scholar 

  38. Vittinghoff E, Douglas J, Judson F, McKirnan D, MacQueen K, Buchbinder SP. Per-contact risk of human immunodeficiency virus transmission between male sexual partners. Am J Epidemiol 1999; 150:306–311.

    Article  CAS  PubMed  Google Scholar 

  39. Fiore JR, Zhang YJ, Bjorndal A, et al. Biological correlates of HIV-1 heterosexual transmission. AIDS 1997; 11:1089–1094.

    Article  CAS  PubMed  Google Scholar 

  40. Hisada M, O’Brien TR, Rosenberg PS, Goedert JJ. Virus load and risk of heterosexual transmission of human immunodeficiency virus and hepatitis C virus by men with hemophilia. The Multicenter Hemophilia Cohort Study. J Infect Dis 2000; 181:1475–1478.

    Article  CAS  PubMed  Google Scholar 

  41. Tovanabutra S, Robison V, Wongtrakul J, et al. Male viral load and heterosexual transmission of HIV-1 subtype E in northern Thailand. J Acquir Immune Defic Syndr 2002; 29:275–283.

    PubMed  Google Scholar 

  42. Pedraza MA, del Romero J, Roldan F, et al. Heterosexual transmission of HIV-1 is associated with high plasma viral load levels and a positive viral isolation in the infected partner. J Acquir Immune Defic Syndr 1999; 21:120–125.

    CAS  PubMed  Google Scholar 

  43. Ragni MV, Faruki H, Kingsley LA. Heterosexual HIV-1 transmission and viral load in hemophilic patients. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 17:42–45.

    Article  CAS  PubMed  Google Scholar 

  44. Stephenson JM, Imrie J, Davis MM, et al. Is use of antiretroviral therapy among homosexual men associated with increased risk of transmission of HIV infection? Sex Transm Infect 2003; 79:7–10.

    Article  CAS  PubMed  Google Scholar 

  45. Coombs RW, Reichelderfer PS, Landay AL. Recent observations on HIV type-1 infection in the genital tract of men and women. AIDS 2003; 17:455–480.

    Article  PubMed  Google Scholar 

  46. Chakraborty H, Sen PK, Helms RW, et al. Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model. AIDS 2001; 15:621–627.

    Article  CAS  PubMed  Google Scholar 

  47. Cohen MS, Hoffman IF, Royce RA, et al. Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research Group. Lancet 1997; 349:1868–1873.

    CAS  Google Scholar 

  48. Ghys PD, Fransen K, Diallo MO, et al. The associations between cervicovaginal HIV shedding, sexually transmitted diseases and immunosuppression in female sex workers in Abidjan, Cote d’Ivoire. AIDS 1997; 11:F85–F93.

    Article  CAS  PubMed  Google Scholar 

  49. Grosskurth H, Mosha F, Todd J, et al. Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial. Lancet 1995; 346:530–536.

    Article  CAS  PubMed  Google Scholar 

  50. Weiss HA, Quigley MA, Hayes RJ. Male circumcision and risk of HIV infection in subSaharan Africa: a systematic review and meta-analysis. AIDS 2000; 14:2361–2370.

    Article  CAS  PubMed  Google Scholar 

  51. Moss GB, Clemetson D, D’Costa L, et al. Association of cervical ectopy with heterosexual transmission of human immunodeficiency virus: results of a study of couples in Nairobi, Kenya. J Infect Dis 1991; 164:588–591.

    Article  CAS  PubMed  Google Scholar 

  52. Hoffman TL, MacGregor RR, Burger H, Mick R, Doms RW, Collman RG. CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status. J Infect Dis 1997; 176:1093–1096.

    Article  CAS  PubMed  Google Scholar 

  53. Paxton WA, Kang S, Koup RA. The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression. AIDS Res Hum Retroviruses 1998; 1(Suppl 1):S89–S92.

    Google Scholar 

  54. D’Ubaldo C, Serraino D, Peroni M, Ippolito G. Do chemokines play a role in HIV-1 heterosexual transmission? Susceptibility to HIV infection. J Biol Regul Homeost Agents 1999; 3:97–102.

    Google Scholar 

  55. Philpott S, Weiser B, Tarwater P, et al. CC chemokine receptor 5 genotype and susceptibility to transmission of human immunodeficiency virus type 1 in women. J Infect Dis 2003; 187: 569–575.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  56. Wang CC, Reilly M, Kreiss JK. Risk of HIV infection in oral contraceptive pill users: a metaanalysis. J Acquir Immune Defic Syndr 1999; 21:51–58.

    Article  CAS  PubMed  Google Scholar 

  57. Wang CC, McClelland RS, Overbaugh J, et al. The effect of hormonal contraception on genital tract shedding of HIV-1. AIDS 2004; 18:205–209.

    Article  PubMed  Google Scholar 

  58. Prakash M, Kapembwa MS, Gotch F, Patterson S. Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4(+) T cells in the cervical epithelium of healthy women. J Reprod Immunol 2002; 54:117–131.

    Article  CAS  PubMed  Google Scholar 

  59. Marx PA, Spira AI, Gettie A, et al. Progesterone implants enhance SIV vaginal transmission and early virus load. Nat Med 1996; 2:1084–1089.

    Article  CAS  PubMed  Google Scholar 

  60. Lavreys L, Chohan V, Overbaugh J, et al. Hormonal contraception and risk of cervical infections among HIV-1-seropositive Kenyan women. AIDS 2004; 18:2179–2184.

    Article  PubMed  Google Scholar 

  61. Roddy RE, Zekeng L, Ryan KA, Tamoufe U, Weir SS, Wong EL. A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases. N Engl J Med 1998; 339:504–510.

    Article  CAS  PubMed  Google Scholar 

  62. Van Damme L, Ramjee G, Alary M, et al. Effectiveness of COL-1492, a nonoxynol-9vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. Lancet 2002; 360:971–977.

    Article  PubMed  Google Scholar 

  63. Peters B, Whittall T, Babaahmady K, Gray K, Vaughan R, Lehner T. Effect of heterosexual intercourse on mucosal alloimmunisation and resistance to HIV-1 infection. Lancet 2004; 363:518–524.

    Article  PubMed  Google Scholar 

  64. Money DM, Arikan YY, Remple V, et al. Genital tract and plasma human immunodeficiency virus viral load throughout the menstrual cycle in women who are infected with ovulatory human immunodeficiency virus. Am J Obstet Gynecol 2003; 188:122–128.

    Article  PubMed  Google Scholar 

  65. Benki S, Mostad SB, Richardson BA, Mandaliya K, Kreiss JK, Overbaugh J. Cyclic shedding of HIV-1 RNA in cervical secretions during the menstrual cycle. J Infect Dis 2004; 189:2192–2201.

    Article  CAS  PubMed  Google Scholar 

  66. Reichelderfer PS, Coombs RW, Wright DJ, et al. Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract. WHS 001 Study Team. AIDS 2000; 14:2101–2107.

    Article  CAS  PubMed  Google Scholar 

  67. Embretson J, Zupancic M, Ribas JL, et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 1993; 362:359–362.

    Article  CAS  PubMed  Google Scholar 

  68. Iweala OI. HIV diagnostic tests: an overview. Contraception 2004; 70:141–147.

    Article  PubMed  Google Scholar 

  69. Mylonakis E, Paliou M, Lally M, Flanigan TP, Rich JD. Laboratory testing for infection with the human immunodeficiency virus: established and novel approaches. Am J Med 2000; 109:568–576.

    Article  CAS  PubMed  Google Scholar 

  70. Otten RA, Smith DK, Adams DR, et al. Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2). J Virol 2000; 74:9771–9775.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  71. Tsai CC, Emau P, Follis KE, et al. Effectiveness of postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment. J Virol 1998; 72:4265–4273.

    CAS  PubMed Central  PubMed  Google Scholar 

  72. Schechter M, Largo RF, Ismerio R, et al. Acceptability, behaviorly impact, and possible efficacy of sexual exposure chemoprophylaxis (PEP) for HIV. In: Programme and Abstracts of the 9th Conference of Retroviruses and Opportunistic Infections. Seattle, WA: February 24–28, 2002.

    Google Scholar 

  73. Schechter M. Occupational and sexual PEP—benefit/risk? In: Programme and Abstracts of the 6th International Conference on Drug Therapy in HIV Infection. Glasgow, UK: November 17–-21, 2002.

    Google Scholar 

  74. Smith DK, Grohskopf LA, Black RJ, et al. Antiretroviral postexposure prophylaxis after sexual, injection-drug use, or other nonoccupational exposure to HIV in the United States: recommendations from the U.S. Department of Health and Human Services. MMWR Recomm Rep 2005; 54:1–20.

    PubMed  Google Scholar 

  75. Merchant RC, Mayer KH. Perspectives on new recommendations for nonoccupational HIV postexposure prophylaxis. JAMA 2005; 293:2407–2409.

    Article  CAS  PubMed  Google Scholar 

  76. Cardo DM, Culver DH, Ciesielski CA, et al. A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group. N Engl J Med 1997; 337:1485–1490.

    Article  CAS  PubMed  Google Scholar 

  77. US Public Health Service. Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis. MMWR Recomm Rep 2001; 50:1–52.

    Google Scholar 

  78. Stratton P, Tuomala RE, Abboud R, et al. Obstetric and newborn outcomes in a cohort of HIV-infected pregnant women: a report of the women and infants transmission study. J Acquir Immune Defic Syndr Hum Retrovirol 1999; 20:179–186.

    Article  CAS  PubMed  Google Scholar 

  79. Langsten C, Lewis DE, Hammill HA, et al. Excess intrauterine fetal demise associated with maternal human immunodeficiency virus infection. J Infect Dis 1995; 172:1451–1460.

    Article  Google Scholar 

  80. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines 2002. MMWR 2002 51:7–11.

    Google Scholar 

  81. Kuhn L, Steketee RW, Weedon J, et al. Distinct risk factors for intrauterine and intrapartum human immunodeficiency virus transmission and consequences for disease progression in infected children. Perinatal AIDS Collaborative Transmission Study. J Infect Dis 1999; 179: 52–58.

    Article  CAS  PubMed  Google Scholar 

  82. Landesman SH, Kalish LA, Burns DN, et al. Obstetrical factors and the transmission of human immunodeficiency virus type 1 from mother to child. The Women and Infants Transmission Study. N Engl J Med 1996; 334:1617–1623.

    Article  CAS  PubMed  Google Scholar 

  83. Mofenson LM, Lambert JS, Stiehm ER, et al. Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team. N Engl J Med 1999; 341:385–393.

    Article  CAS  PubMed  Google Scholar 

  84. The European Collaborative Study. Maternal viral load and vertical transmission of HIV-1: an important factor but not the only one. AIDS 1999; 13:1377–1385.

    Google Scholar 

  85. Garcia PM, Kalish LA, Pitt J, et al. Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group. N Engl J Med 1999; 341:394–402.

    Article  CAS  PubMed  Google Scholar 

  86. Nduati R, John G, Mbori-Ngacha D, et al. Effect of breastfeeding and formula feeding on transmission of HIV-1: arandomized clinical trial. JAMA 2000; 283:1167–1174.

    Article  CAS  PubMed  Google Scholar 

  87. ACOG Committee on Obstetric Practice. ACOG committee opinion number 304, November 2004. Prenatal and perinatal human immunodeficiency virus testing: expanded recommendations. Obstet Gynecol 2004; 104:1119–1124.

    Article  Google Scholar 

  88. The European Mode of Delivery Collaboration. Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trial. Lancet 1999; 353:1035–1039. Erratum in: Lancet 1999; 353:1714.

    Article  Google Scholar 

  89. Davis KR, Weller SC. The effectiveness of condoms in reducing heterosexual transmission of HIV. Farn Plann Perspect 1999; 31:272–279.

    Article  CAS  Google Scholar 

  90. Samuel MC, Hessol N, Shiboski S, Engel RR, Speed TP, Winkelstein W Jr. Factors associated with human immunodeficiency virus seroconversion in homosexual men in three San Francisco cohort studies, 1984–1989. J Acquir Immune Defic Syndr 1993; 6:303–312.

    CAS  PubMed  Google Scholar 

  91. Golombok S, Sheldon J. Evaluation of a thicker condom for use as a prophylactic against HIV transmission. AIDS Educ Prev 1994; 6:454–458.

    CAS  PubMed  Google Scholar 

  92. Golombok S, Harding R, Sheldon J. An evaluation of a thicker versus a standard condom with gay men. AIDS 2001; 15:245–250.

    Article  CAS  PubMed  Google Scholar 

  93. Mitchell HS, Stephens E. Contraception choice for HIV positive women. Sex Transm Infect 2004; 80:167–173.

    Article  CAS  PubMed  Google Scholar 

  94. Lederman MM, Veazey RS, Offord R, et al. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science 2004; 306:485–487.

    Article  CAS  PubMed  Google Scholar 

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Rieg, G. (2006). HIV Infection and AIDS. In: Nelson, A.L., Woodward, J., Wysocki, S. (eds) Sexually Transmitted Diseases. Current Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59745-040-9_5

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