Abstract
The last decade of the 20th century saw the emergence of a new paradigm in clinical decision making with the appearance of evidence-based medicine (EBM) (1). The ultimate in the hierarchy of evidence in EBM is the randomized controlled clinical trial (RCT). Unfortunately, the N-of-1 RCT, ideal for evaluating the effectiveness of interventions in the individual patient, is rarely feasible or if feasible, is rarely conducted.
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© 2006 Mayo Foundation for Medical Education and Research
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Isley, W.L. (2006). Clinical Research Center-Based Investigations and Evidence-Based Medicine. In: Montori, V.M. (eds) Evidence-Based Endocrinology. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59745-008-9_11
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DOI: https://doi.org/10.1007/978-1-59745-008-9_11
Publisher Name: Humana Press
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