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Concurrent Chemoradiotherapy

Impact on Survival and Organ Preservation

  • Chapter
Squamous Cell Head and Neck Cancer

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Initial efforts to integrate systemic chemotherapy into the definitive management of squamous cell head and neck cancer focused on sequential treatment schedules. Given the impressive response rates seen with multiagent chemotherapy in previously untreated patients, considerable effort went into the study of induction or neoadjuvant treatment schedules (1). Numerous randomized trials have now been completed. Although induction chemotherapy has been generally well tolerated, and appears to decrease the likelihood of distant metastatic disease, no consistent survival benefit has been demonstrated from this treatment approach alone (2).

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Author information

Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, OH

    David J. Adelstein MD

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  1. David J. Adelstein MD
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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, OH

    David J. Adelstein MD

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© 2005 Humana Press Inc., Totowa, NJ

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Adelstein, D.J. (2005). Concurrent Chemoradiotherapy. In: Adelstein, D.J. (eds) Squamous Cell Head and Neck Cancer. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-59259-938-7_13

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  • DOI: https://doi.org/10.1007/978-1-59259-938-7_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-473-9

  • Online ISBN: 978-1-59259-938-7

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