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Platelet Function pp 315–331Cite as

Genomic and Proteomic Analysis of Platelets

Clinical Applications

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Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

The platelet is a circulating anucleate cell particle created from the cytoplasm of megakaryocytes in the bone marrow from whence it derives much of its cytoplasmic content. Deposited at sites of vascular injury, its role in the processes of thrombosis and haemostasis is well defined. Many important insights into the platelets haemostatic role were gained through genetic studies of rare inherited bleeding disorders such as Glanzmann’s thrombesthenia and Bernard-Soulier disease (1,2). It is now clear, however, that its physiological role extends beyond that of thrombosis to include regulation of inflammation, tissue repair, and the immune response, and one could argue that these are its predominant functions (3).

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Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland

    Andrew Maree MD

  2. The Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin, Ireland

    James McRedmond PhD

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  1. Andrew Maree MD
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  2. James McRedmond PhD
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Editors and Affiliations

  1. Department of Cardiology, St. Vincent’s University Hospital, Dublin, Ireland

    Martin Quinn MB BCh BAO, PhD

  2. University College Dublin, Dublin, Ireland

    Desmond Fitzgerald MD, FRCPI, FESC, AAP (Vice President of Research) (Vice President of Research)

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© 2005 Humana Press Inc., Totowa, NJ

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Maree, A., McRedmond, J. (2005). Genomic and Proteomic Analysis of Platelets. In: Quinn, M., Fitzgerald, D. (eds) Platelet Function. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59259-917-2_14

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  • DOI: https://doi.org/10.1007/978-1-59259-917-2_14

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-244-5

  • Online ISBN: 978-1-59259-917-2

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