Abstract
Alcmaeon, a sixth-century bc physiologist philosopher, introduced the brain as the center of human thinking, organizer of the senses, and coordinator for survival. However, the need for a visible connection between the brain and the rest of the body to explain a rapid and effective way of communication that would maintain homeostasis led Aristotle to the erroneous conclusion that the heart was the central coordinating organ and blood the means of information transmission. In contemporary medicine, the two ancient concepts are integrated in the exciting field of neuroendocrinology. The traditional distinctions between neural (brain) and hormonal (blood) control have become blurred. Endocrine secretions are influenced directly or indirectly by the central nervous system (CNS), and many hormones influence brain function. The hypothalamic-pituitary unit is the mainstay of this nonstop, interactive, and highly efficient connection between the two systems. Its function is mediated by hypothalamic-releasing or hypothalamic-inhibiting hormones, including gonadotropin-releasing hormone (GnRH), thyrotropin-releasing hormone (TRH), growth hormone-releasing hormone (GHRH), somatostatin (SRIF), corticotropin-releasing hormone (CRH), and the neurotransmitter dopamine.
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Reference
Chrousos GP, Gold PW. The concepts of stress and stress system disorders: an overview of physical and behavioral homeostasis. JAMA 1992;267:1244–1252.
Selected Reading
Ben-Jonathan N, Hnasko R. Dopamine as a prolactin (PRL) inhibitor. EndocrRev 2001;22:724–763.
Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 1995;332:1351–1362.
Chrousos GP. The role of stress and the hypothalamic-pituitaryadrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes [review]. Int J Obesity 2000;24:S50–S55.
Conn PM, Janovick JA, Stanislaus D, Kuphal D, Jennes L. Molecular and cellular bases of GnRH action in the pituitary and central nervous system. Vitam Horm 1995;50:151–214.
De La Escalera GM, Weiner RI. Dissociation of dopamine from its receptor as a signal in the pleiotropic hypothalamic regulation of prolactin secretion. Endocr Rev 1992;13:241–255.
Frohman LA, Downs TR, Chomzynski P. Regulation of growth hormone secretion. Front Neuroendocrinol 1992;13:344–405.
Gold PW, Chrousos GP. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs. low CRH/NE states. Mol Psychiatry 2002;254–275.
Grammatopoulos D, Chrousos GP. Structural and signaling diversity of corticotropin-releasing hormone (CRH) and related peptides and their receptors: potential clinical applications of CRH receptor antagonists. Trends Endocrinol Metab 2002;13:436–444.
Jackson IMD, Lechan RM, Lee SL. TRH-prohormone: biosynthesis, anatomic distribution and processing. Front Neuroendocrinol 1990;11:267–283.
Kalantaridou SN, Chrousos GP. Monogenic disorders of puberty. J Clin Endocrinol Metab 2002;87:2481–2494.
King JC, Rubin BS. Dynamic changes in LHRH neurovascular terminals with various endocrine conditions in adults. Horm Behav 1994;28:349–356.
Korbonits M, Grossman AB. Growth hormone-releasing peptide and its analogues: novel stimuli to growth hormone release. Trends Endocrinol Metab 1995;6:43–49.
Makrigiannakis A, Zoumakis E, Kalantaridou S, Mitsiadis N, Margioris N, Chrousos G, Gravanis A. Corticotropin-releasing hormone (CRH) and immunotolerance of the fetus. Biochem Pharmacol 2003;65:917–921.
Rivest S. Rivier C. The role of corticotropin-releasing factor and interleukin-1 in the regulation of neurons controlling reproductive functions. Endocr Rev 1995;16:177–199.
Schwanzel-Fukuda M, Jorgenson KL, Bergen HT, Weesner GD, Pfaff DW. Biology of normal LHRH neurons during and after their migration from olfactory placode. Endocr Rev 1992;13:623–634.
Sherwood NM, Lovejoy DA, Coe IR. Origin of mammalian gonadotropin-releasing hormones. Endocr Rev 1993;14:241–254.
Spada A, Faglia G. G-proteins and hormonal signalling in human pituitary tumors: genetic mutations and functional alterations. Front Neuroendocrinol 1993;14:214–232.
Vamvakopoulos NC, Chrousos GP. Hormonal regulation of human corticotropin-releasing hormone gene expression: implications for the stress response and immune/inflammatory reaction. Endocr Rev 1994;15:409–420.
Vgontzas AN, Chrousos GP. Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders. Endocrinol Metab Clin in North Am 2002;31:15–36.
Viollet C, Prevost G, Maubert E, et al. Molecular pharmacology of somatostatinreceptors. Fundam Clin Pharmacol 1995;9:107–113.
Wehrenberg WB, Giustina A. Basic counterpoint: mechanisms and pathways of gonadal steroid stimulation of growth hormone secretion. Endocr Rev 1992;13:299–308.
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© 2005 Humana Press Inc., Totowa, NJ
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Stratakis, C.A., Chrousos, G.P. (2005). Hypothalamic Hormones. In: Melmed, S., Conn, P.M. (eds) Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59259-829-8_12
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DOI: https://doi.org/10.1007/978-1-59259-829-8_12
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